Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex

Shi, Jieyun; Li, Qian; Wen, Tao

doi:10.1007/s12264-018-0211-0

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…The association between altered GABA levels and vision abnormity has also been reported frequently. Visual deficit-poor vision-was found to be rendered by loss of dendritic cell factor 1 through the GABA system in mouse primary visual cortex [56]. In the early stage of type 2 diabetes, occipital cortical GABA has been reported to be a novel predictor of visual psychophysical performance, that is, speed and achromatic discrimination thresholds [57].…”

Section: Discussionmentioning

confidence: 99%

High level of pattern glare in major depressive disorder

Fan

Yang

et al. 2019

BMC Psychiatry

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BackgroundVisual deficits have been reported in abundance by recent studies on major depressive disorder. Pattern glare manifests as visual distortions, such as the symptoms of headache, glare, eyestrain, illusions of shapes, colors, and motion when viewing repetitive striped patterns, of which some can be observed in major depressive disorder. Inspired by what mentioned, the present study aims to explore whether there exists association between pattern glare and major depressive disorder and further attempts to explore possible clinical diagnostic value of pattern glare in major depressive disorder.MethodsTwenty-four patients diagnosed with major depressive disorder (MDDs group) were compared with 30 age-, gender- and education level-matched healthy control subjects (HCs group) on their visual stress with black-and-white gratings of different spatial frequencies-0.3 (low-SF), 2.3 (mid-SF), and 9.4 (high-SF) cycles per degree (c/deg)-which was named pattern glare test. The MDDs group divided into first episode medication-free group (fMDD) and recurrent medicated group (rMDD), comparisons of pattern glare scores (PGS) were performed within the MDDs group. We used Pearson and Spearman analysis to explore the relationship between some clinical indexes and pattern glare scores. ROC (receiver operating characteristic) curve was used to evaluate whether pattern glare test was able to discriminate patients and healthy controls.ResultsThe mid-SF pattern glare score significantly elevated in patients with major depressive disorder compared to control subjects. No differences of pattern glare scores were found between fMDD and rMDD. A significant negative correlation between mid-high difference and age in HCs group was found. There were no correlations between other variables and pattern glare scores. The mid-SF score has limited value in the diagnosis of major depressive disorder.ConclusionsWe observed an increased level of pattern glare in patients with major depressive disorder, reflecting the existence of cortical hyper-excitability in major depressive disorder. The mid-SF score may have a value in understanding cortical excitability in major depressive disorder.

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Section: Discussionmentioning

confidence: 99%

High level of pattern glare in major depressive disorder

Fan

Yang

et al. 2019

BMC Psychiatry

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“…ACE2 overexpression facilitates GABA release and enhances inhibitory transmission in the RVLM [ 55 ]. However, GABA can cause a decrease in ACh release [ 56 , 57 ]. So the GABA mechanism may also be involved in the improvement of cholinergic transmission mediated by ACE2 overexpression.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

Deng

Tan

et al. 2018

Neurosci. Bull.

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The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensinconverting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.

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“…Online subject education requires that the data collected be relevant, reliable, and timely. Applying big data technology to the data transformation process of online subject education by using padding for document transformation can avoid the problem of large errors in the data collection process [14][15]. Based on the DCF mechanism (discounted free cash method), the designed data channel reservation framework is shown in Figure 1.…”

Section: Transforming Document Datamentioning

confidence: 99%

The application of big data technology in online subject education innovation research

Huang,

Tan,

Yan

et al. 2023

3C Tecnología

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This paper applies big data technology to promote the innovative development of online subject education and improve students' self-learning efficiency to promote innovative management interaction in the education industry. In the design process, big data technology is used to mine and analyze massive educational data, combine the learning needs of online subjects, and provide technical support for six application levels of the online subject education system. Document transformation of education data is performed through the DCF mechanism, and the synchronization time slot is divided into a safe time slot and a reservation time slot. Then, the adaptive recommendation function is used to extract valuable information from behavioral data for personalized learning resource pushing. To verify the practical application effect of big data technology in the online subject education innovation system, the simulation analysis results show that after applying big data technology, the recommended resources preference of the education system is above 86%, the subject coverage rate is 90.48%, and the performance of test scores is improved by 17.5% relative to Class C. This shows that big data technology optimizes the application mode of online subject education and can provide students with better-quality educational resources.

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Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex

Cited by 7 publications

References 30 publications

High level of pattern glare in major depressive disorder

High level of pattern glare in major depressive disorder

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

The application of big data technology in online subject education innovation research

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