Dendritic cell homeostasis

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local progression and distant metastasis. Therefore, targeting monocytes and macrophages is a promising immunotherapeutic approach. This review will focus on the development of monocytes as macrophage precursors, the functions of tumorassociated macrophages and the possibility of interfering with tumor development and progression by targeting these myeloid cells.

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“…1). The biology of DCs and their relationship to monocytes have been discussed elsewhere in detail [3,11,54,55].…”

Section: Development and Functions Of Macrophagesmentioning

confidence: 99%

Monocytes and Macrophages in Cancer: Development and Functions

Richards

Hettinger

Feuerer

2012

Cancer Microenvironment

171

122

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“…Based on the transcriptomic [33], functional [30,34] and developmental [35] [31,33]. Both subsets selectively express the membrane markers CADM1 [36], CLEC9A [37][38][39] and XCR1 [33,40,41] but are negative for SIRPa.…”

Section: Toward a Unifying Classification Of DC Subsets Across Tissuementioning

confidence: 99%

From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets

et al. 2010

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Recent studies have identified several DC subsets within the mouse skin and showed that functional specialization exists among them. This Viewpoint summarizes recent data on functional specialization of skin DC subsets and integrates this knowledge into a unifying DC classification that emphasizes the similarities between the DC subsets found in both lymphoid and nonlymphoid tissues of several mammalian species.

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“…In contrast, different tissue DC subsets coexist in environmental surfaces, such as the skin. Langerhans cells, the first DC subpopulation described (14), express high levels of langerin, a C-type lectin receptor, and CD1a (9). Langerin is also expressed in lymphoid CD8a + DCs and on a subpopulation of tissue DCs that coexpress high levels of CD103 + (15).…”

Section: Endritic Cells (Dcs) Belong To the Family Of Professionalmentioning

confidence: 99%

“…Among cDCs, murine lymphoid tissue-resident DCs include two major subsets defined as CD4 + CD8a 2 CD11b + and CD8a + CD4 2 CD11b 2 DCs, respectively. Recently, an additional CD4 2 CD8a 2 CD11b + DC subtype was described (9). In the same species, CD8a + DCs congregate in T cell areas of secondary lymphoid tissues, whereas they are absent from nonlymphoid tissues (11) and are considered a nonmigratory DC population derived from blood-borne DC precursors (12) that is specialized in MHC class I presentation and cross-presentation of cell-associated Ags (13).…”

Section: Endritic Cells (Dcs) Belong To the Family Of Professionalmentioning

confidence: 99%

“…DCs can be divided into two major subtypes: nonlymphoid tissue-migratory and tissue-resident DCs, sometimes categorized as conventional DCs (cDCs) and plasmacytoid DCs. cDCs are implicated in maintaining tolerance and triggering adaptive immune responses against invading pathogens (1,8,9), whereas plasmacytoid DCs are primarily focused on secreting type I IFN in response to viral infections (10). Among cDCs, murine lymphoid tissue-resident DCs include two major subsets defined as CD4 + CD8a 2 CD11b + and CD8a + CD4 2 CD11b 2 DCs, respectively.…”

Section: Endritic Cells (Dcs) Belong To the Family Of Professionalmentioning

confidence: 99%

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Identification of Teleost Skin CD8α+ Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells

Granja¹,

Leal²,

Pignatelli³

et al. 2015

The Journal of Immunology

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Although fish constitute the most ancient animal group in which an acquired immune system is present, the presence of dendritic cells (DCs) in teleosts has been addressed only briefly, and the identification of a specific DC subset in teleosts remained elusive because of the lack of specific Abs. In mice, DCs expressing CD8α+ in lymphoid tissues have the capacity to cross-present extracellular Ags to T cells through MHC I, similarly to tissue-derived CD103+ DCs and the human CD141+ DC population. In the current study, we identified a large and highly complex subpopulation of leukocytes coexpressing MHC class II and CD8α. This CD8α+ MHC II+ DC-like subpopulation constituted ∼1.2% of the total leukocyte population in the skin, showing phenotypical and functional characteristics of semimature DCs that seem to locally regulate mucosal immunity and tolerance in a species lacking lymph nodes. Furthermore, we identified trout homologs for CD141 and CD103 and demonstrated that, in trout, this skin CD8+ DC-like subpopulation expresses both markers. To our knowledge, these results provide the first evidence of a specific DC-like subtype in nonimmune tissue in teleosts and support the hypothesis of a common origin for all mammalian cross-presenting DCs.

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Dendritic cell homeostasis

Cited by 333 publications

References 128 publications

Monocytes and Macrophages in Cancer: Development and Functions

Monocytes and Macrophages in Cancer: Development and Functions

From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets

Identification of Teleost Skin CD8α+ Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells

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