Dendritic cell neurofibroma with pseudorosettes: One case report and literature review

Dendritic cell neurofibroma with pseudorosettes

“…The exact etiology of the disease is unknown. It typically presents as a sporadic, solitary skin‐colored papule or nodule (mean size: 8 mm) and can arise on different parts of the body, most often the trunk 4‐12 . A skin biopsy is necessary to make a diagnosis.…”

“…Both types I and II cells stain positively for S100 and CD57, suggesting neural differentiation with a dermal interstitial dendritic cell lineage. CD34 has also been established as a useful marker in identifying fibroblasts in the stroma 8 . EMA IHC can identify focal perineurium around the tumor.…”

“…DCNP has a benign clinical course and is usually managed by excision for cosmetic reasons or if the lesion is bothersome. There have not been any reports of malignancy or reoccurrence 4‐12 …”

“…In 2002, Woodruff et al debated this finding and instead suggested it may be an atypical type of melanocytic nevus with neural differentiation due to the lesion having S100 protein reactivity and multifocal tumor growth 13 . However, subsequent cases refuted this theory and have supported DCNP to be a true PNST after additional immunohistochemical staining with CD57 showed neural differentiation 8 . In April 2020, Saggini et al had conflicting opinions about its classification as a neurofibroma.…”

“…It typically presents as a sporadic, solitary skincolored papule or nodule (mean size: 8 mm) and can arise on different parts of the body, most often the trunk. [4][5][6][7][8][9][10][11][12] A skin biopsy is necessary type II cells to form the distinctive pseudorosette. 4 It is beneficial to use immunohistochemical (IHC) staining to differentiate it from other forms of neurofibromas accurately.…”