Dendritic Cell Subsets, Maturation and Function

Al-Ashmawy, Ghada M.

doi:10.5772/intechopen.79926

Cited by 16 publications

(16 citation statements)

References 50 publications

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“…DC is well-known as the most potent APC and plays a pivotal role in innate and adaptive human immune systems ( 10 ). In the innate immune system, DC introduces and determines the body’s response to DAMP or PAMP.…”

Section: Role Of Dendritic Cell In Shapingt Cell Immunitymentioning

confidence: 99%

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Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic

et al. 2022

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Finding a vaccine that can last a long time and effective against viruses with high mutation rates such as SARS-CoV-2 is still a challenge today. The various vaccines that have been available have decreased in effectiveness and require booster administration. As the professional antigen presenting cell, Dendritic Cells can also activate the immune system, especially T cells. This ability makes dendritic cells have been developed as vaccines for some types of diseases. In SARS-CoV-2 infection, T cells play a vital role in eliminating the virus, and their presence can be detected in the long term. Hence, this condition shows that the formation of T cell immunity is essential to prevent and control the course of the disease. The construction of vaccines oriented to induce strong T cells response can be formed by utilizing dendritic cells. In this article, we discuss and illustrate the role of dendritic cells and T cells in the pathogenesis of SARS-CoV-2 infection and summarizing the crucial role of dendritic cells in the formation of T cell immunity. We arrange the basis concept of developing dendritic cells for SARS-CoV-2 vaccines. A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems.

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Section: Role Of Dendritic Cell In Shapingt Cell Immunitymentioning

confidence: 99%

“…Dendritic cells (DC) have a pivotal role in the immune system, which connects the activation of the innate and adaptive immune systems. In addition, DC is well-known for its ability to activate and differentiate naïve T cells ( 10 ). DC has been developed as an immunotherapy or vaccine for cancer and infections ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic

et al. 2022

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“…They promote an immune response to exogenous bodies and maintains self-tolerance. These cells serve as a bridge between innate and adaptive immune systems of our body (40). Providing co-stimulation and cytokines necessary for T-cell activation is also a function of DCs.…”

Section: Mirna Regulation Of Granulocytesmentioning

confidence: 99%

Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases

2020

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MicroRNAs (miRNAs, miRs) are short, endogenously initiated, non-coding RNAs that bind to target mRNAs, leading to the degradation or translational suppression of respective mRNAs. They have been reported as key players in physiological processes like differentiation, cellular proliferation, development, and apoptosis. They have gained importance as gene expression regulators in the immune system. They control antibody production and release various inflammatory mediators. Abnormal expression and functioning of miRNA in the immune system is linked to various diseases like inflammatory disorders, allergic diseases, cancers etc. As compared to the average human genome, miRNA targets the genes of immune system quite differently. miRNA appeared to regulate the responses related to both acquired and innate immunity of the humans. Several miRNAs importantly regulate the transcription and even, dysregulation of inflammation-related mediators. Many miRNAs are either upregulated or downregulated in various inflammatory and infectious diseases. Hence, modifying or targeting the expression of miRNAs might serve as a novel strategy for the diagnosis, prevention, and treatment of various inflammatory and infectious conditions.

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“…Dendritic cells are professional antigen-presenting cells that effectively link the innate and adaptive arms of the immune system; they are therefore critical for the induction of protective immune responses against pathogens and tumor cells [ 64 ]. DC maturation correlates with upregulation of cell surface major histocompatibility complex (MHC) gene products, costimulatory molecules and chemokine receptors that facilitate DC migration to secondary lymphoid tissue, where these cells present antigen to T cells [ 65 ].…”

Section: Immune Functions Of Hmgb1mentioning

confidence: 99%

High Mobility Group Box 1 in Human Cancer

Rapoport

Steel

Theron

et al. 2020

Cells

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High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. During cellular stress, however, this multifaceted, cytokine-like protein undergoes posttranslational modifications that promote its translocation to the cytosol, from where it is released extracellularly, either actively or passively, according to cell type and stressor. In the extracellular milieu, HMGB1 triggers innate inflammatory responses that may be beneficial or harmful, depending on the magnitude and duration of release of this pro-inflammatory protein at sites of tissue injury. Heightened awareness of the potentially harmful activities of HMGB1, together with a considerable body of innovative, recent research, have revealed that excessive production of HMGB1, resulting from misdirected, chronic inflammatory responses, appears to contribute to all the stages of tumorigenesis. In the setting of established cancers, the production of HMGB1 by tumor cells per se may also exacerbate inflammation-related immunosuppression. These pro-inflammatory mechanisms of HMGB1-orchestrated tumorigenesis, as well as the prognostic potential of detection of elevated expression of this protein in the tumor microenvironment, represent the major thrusts of this review.

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Dendritic Cell Subsets, Maturation and Function

Cited by 16 publications

References 50 publications

Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic

Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic

Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases

High Mobility Group Box 1 in Human Cancer

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