Dendritic cells and the malaria pre-erythrocytic stage

Mauduit, Marjorie; See, Peter; Peng, Kaitian; Rénia, Laurent; Ginhoux, Florent

doi:10.1007/s12026-012-8269-7

Cited by 14 publications

(14 citation statements)

References 109 publications

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“…During the Plasmodium infection, the parasite develops tropism towards DCs, which phagocytose the infected RBCs. 35,36 Inside DCs, the parasite produces hemozoin, a product of haemoglobin degradation, ultimately leading to impaired DC maturation. 12 In vitro hemozoin-treated DCs acquire immunosuppressive abilities such as reduced expression of co-stimulatory molecules CD80 and CD86, secretion of IL-10 and induction of Treg cells.…”

Section: Discussionmentioning

confidence: 99%

Dendritic cells treated with crude Plasmodium berghei extracts acquire immune‐modulatory properties and suppress the development of autoimmune neuroinflammation

et al. 2014

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SummaryDendritic cells (DCs) are professional antigen-presenting cells specifically targeted during Plasmodium infection. Upon infection, DCs show impaired antigen presentation and T-cell activation abilities. In this study, we aimed to evaluate whether cellular extracts obtained from Plasmodium berghei-infected erythrocytes (PbX) modulate DCs phenotypically and functionally and the potential therapeutic usage of PbX-modulated DCs in the control of experimental autoimmune encephalomyelitis (EAE, the mouse model for human multiple sclerosis). We found that PbX-treated DCs have impaired maturation and stimulated the generation of regulatory T cells when cultured with naive T lymphocytes in vitro. When adoptively transferred to C57BL/6 mice the EAE severity was reduced. Disease amelioration correlated with a diminished infiltration of cytokine-producing T cells in the central nervous system as well as the suppression of encephalitogenic T cells. Our study shows that extracts obtained from P. berghei-infected erythrocytes modulate DCs towards an immunosuppressive phenotype. In addition, the adoptive transfer of PbX-modulated DCs was able to ameliorate EAE development through the suppression of specific cellular immune responses towards neuro-antigens. To our knowledge, this is the first study to present evidence that DCs treated with P. berghei extracts are able to control autoimmune neuroinflammation.

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Section: Discussionmentioning

confidence: 99%

Dendritic cells treated with crude Plasmodium berghei extracts acquire immune‐modulatory properties and suppress the development of autoimmune neuroinflammation

et al. 2014

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“…With respect to malaria, the relative contribution of liver resident versus recruited inflammatory DC is unknown to date ( Mauduit et al, 2012 ). Several studies have demonstrated a critical role of CD8α + DCs in the activation of effector CD8 T cells responding to an epitope of CSP.…”

Section: The Hepatic Cycle Of Plasmodium —Implicatmentioning

confidence: 99%

Plasmodium cellular effector mechanisms and the hepatic microenvironment

Frevert

Krzych

2015

Front. Microbiol.

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Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium liver stages. However, malaria liver stage (LS) immunity is complex and the mechanisms effector T cells use to locate the few infected hepatocytes in the large liver in order to kill the intracellular LS parasites remain a mystery to date. Here, we review our current knowledge on the behavior of CD8 effector T cells in the hepatic microvasculature, in malaria and other hepatic infections. Taking into account the unique immunological and lymphogenic properties of the liver, we discuss whether classical granule-mediated cytotoxicity might eliminate infected hepatocytes via direct cell contact or whether cytokines might operate without cell–cell contact and kill Plasmodium LSs at a distance. A thorough understanding of the cellular effector mechanisms that lead to parasite death hence sterile protection is a prerequisite for the development of a successful malaria vaccine to protect the 40% of the world’s population currently at risk of Plasmodium infection.

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“…When washed sporozoites were co-inoculated with or without mosquito saliva intradermally, the presence of saliva induced IL-4 and IL-10. Parasitemia was higher and cerebral malaria developed more frequently (Depinay et al, 2006;Schneider et al, 2011;Mauduit et al, 2012). The saliva of Aedes aegyti also exhibits immunomodulatory properties by inducing lymphocyte but not DC apoptosis in a caspase 3-and 8-dependent pathway (Bizzarro et al, 2013).…”

Section: Vector Saliva a Critical Parameter For Effective Pathogen Tmentioning

confidence: 99%

Smuggling across the Border: How Arthropod-Borne Pathogens Evade and Exploit the Host Defense System of the Skin

Bernard

Jaulhac

Boulanger

2014

Journal of Investigative Dermatology

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The skin is a critical barrier between hosts and pathogens in arthropod-borne diseases. It harbors many resident cells and specific immune cells to arrest or limit infections by secreting inflammatory molecules or by directly killing pathogens. However, some pathogens are able to use specific skin cells and arthropod saliva for their initial development, to hide from the host immune system, and to establish persistent infection in the vertebrate host. A better understanding of the initial mechanisms taking place in the skin should allow the development of new strategies to fight these vector-borne pathogens that are spread worldwide and are of major medical importance.

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Dendritic cells and the malaria pre-erythrocytic stage

Cited by 14 publications

References 109 publications

Dendritic cells treated with crude Plasmodium berghei extracts acquire immune‐modulatory properties and suppress the development of autoimmune neuroinflammation

Dendritic cells treated with crude Plasmodium berghei extracts acquire immune‐modulatory properties and suppress the development of autoimmune neuroinflammation

Plasmodium cellular effector mechanisms and the hepatic microenvironment

Smuggling across the Border: How Arthropod-Borne Pathogens Evade and Exploit the Host Defense System of the Skin

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