2020
DOI: 10.1016/j.smim.2020.101410
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Dendritic cells in the tumor microenvironment: prognostic and theranostic impact

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Cited by 112 publications
(80 citation statements)
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“…In this context, DCs can be viewed as promising targets for cancer immunotherapy. Indeed, increased DC density, mostly of cDCs, within the TME is associated with better prognosis in ovarian carcinoma, lung cancers, and breast cancers (103)(104)(105). However, the TME can elicit multiple mechanisms to perturb DC functions, including decreased production of chemoattractants (e.g., CCL4 and CCL5), which impairs the recruitment of DCs to the tumor bed, and a reduction in survival signals [such as the growth factor FMS-like tyrosine kinase 3 ligand (FLT3L)] required for DC differentiation and viability (106).…”
Section: Dcsmentioning
confidence: 99%
“…In this context, DCs can be viewed as promising targets for cancer immunotherapy. Indeed, increased DC density, mostly of cDCs, within the TME is associated with better prognosis in ovarian carcinoma, lung cancers, and breast cancers (103)(104)(105). However, the TME can elicit multiple mechanisms to perturb DC functions, including decreased production of chemoattractants (e.g., CCL4 and CCL5), which impairs the recruitment of DCs to the tumor bed, and a reduction in survival signals [such as the growth factor FMS-like tyrosine kinase 3 ligand (FLT3L)] required for DC differentiation and viability (106).…”
Section: Dcsmentioning
confidence: 99%
“…The heterogeneity of moDCs may explain the contradictory roles observed in many types of cancers. Notably, moDCs are primarily generated in response to inflammation and promote CD4 + T-cell differentiation towards a Th1, Th2 or Th17 cell phenotype [45]. They are also effective in cross-presenting tumor antigens towards CD8 + T cells and inducing their infiltration into the TME of different mouse tumor models [46].…”
Section: Modcsmentioning
confidence: 99%
“…cDC1 and cDC2 also locally induce IL-12 production and subsequently CD8 + T cell cytotoxicity and IFN-α/β production [60]. cDC2s produce a wide variety of cytokines important for CD4 + T-cell activation and Th1 and Th2 responses, such as IL-1β, IL-6, IL-12 and IL-23 [45].…”
Section: Chemokine Network and Dcs In The Tmementioning
confidence: 99%
“…In the TME, TAMs are mainly of the M2 phenotype, which promote tumor proliferation and metastasis ( 5 ). DC function to present antigens, and those in the TME usually exist in an immature state and promote tumor progression ( 6 ). In addition, MDSC and Treg can promote tumor progression by exerting immunosuppressive effects ( 7 ).…”
Section: Introductionmentioning
confidence: 99%