Dendritic cells, the liver, and transplantation

Sumpter, Tina L.; Abe, Masanori; Tokita, Daisuke; Thomson, Angus W.

doi:10.1002/hep.21974

Cited by 102 publications

(102 citation statements)

References 116 publications

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“…It is well known that dendritic cells (DCs) and regulatory T cells (Tregs) play a pivotal role in inhibiting the rejection of transplantation (11)(12)(13)(14)(15). DCs are professional antigen-presenting cells (APCs) that are specialized for the initiation and regulation of T cell immunity.…”

Section: Introductionmentioning

confidence: 99%

“…For example, expression of MHC-peptide complexes is 10-to 100-fold higher in DCs than in other APCs, such as B cells and macrophages. The function of DCs in organ transplantation has been defined, they can capture allogenic antigen and present it to specific T cells to induce an immune response against donors (11,12). Decreasing the antigen-presenting function of DCs is able to inhibit the rejection of transplantation by DC-induced tolerance (13).…”

Section: Introductionmentioning

confidence: 99%

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Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells

Zhang

Li²,

Bu³

et al. 2011

Int J Mol Med

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Abstract. The aim of this study was to characterize the effects of emodin on dendritic cells (DCs) and CD4 + CD25 + regulatory T cells (Tregs). Myeloid DCs were prepared from peripheral blood mononuclear cells of healthy human donors and treated with emodin at different concentrations. The phenotype and T cell stimulatory capacity of these DCs were analyzed. The expression ratios of CD80 and CD83 in DCs in the presence of emodin (100 µg/ml) were significantly decreased compared with that in DCs without emodin treatment (P<0.05). IL-12p70 production of DCs decreased significantly with emodin treatment (P<0.05). Furthermore, an approximately 2-fold decrease was observed in the ability of DCs pre-treated with emodin to induce T-lymphocyte proliferation. In addition, we found that emodin treatment increased the number of Tregs, which expressed lower levels of human leukocyte antigen (HLA-DR), glucocorticoid-induced tumor necrosis factor receptor (GITR), and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) as compared to cells without emodin treatment. Our results suggest that emodin inhibits the differentiation and maturation of DCs and induces Tregs, which may be helpful for the modulation of the immune rejection after liver transplantation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells

Zhang

Li²,

Bu³

et al. 2011

Int J Mol Med

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show abstract

“…In addition, pDCs synthesize both IL-10 and IL-12. NKDCs express both the NK cell marker DX5 (or NK1.1 in some strain mouse) and DC marker CD11c, which present antigen while exhibiting cytotoxic function and produce IFN-γ via autocrine IL-12 in response to CpG stimulation [41] . Noticeably, lymphoid DC and NKDC are not indentified in humans.…”

Section: Intrahepatic Dendritic Cellsmentioning

confidence: 99%

“…Conventional DCs including lymphoid and myeloid DC are mainly located at the periportal fields and central veins, which are the main initiators of immunity in the liver [40] . They can be expanded strikingly by FMS-like tyrosine kinase 3 ligand (Flt3L) administration [41] . pDCs are mainly located within the liver parenchyma, which are more abundant in the liver than they are in lymphoid tissue.…”

Section: Intrahepatic Dendritic Cellsmentioning

confidence: 99%

Immunology of Liver

Tian

Chen

2012

Primary Liver Cancer

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“…Based on the observed gene expression, 5-HT signaling pathway genes were up-regulated predominantly in HCs, BECs, SECs, and the RL during the progress stage, and were down-regulated predominantly in PCs and DCs during the termination stage (Figure 2). (Luo et al, 1995;Hisama et al, 1996;Enomoto et al, 2004;Guo et al, 2006;Sumpter et al, 2007;Quante and Wang, 2009;Lu et al, 2009). According to expression abundance of 5-HT signaling pathway genes and the proportion of cells in the liver to calculate synthetic effects of 8 types of liver cells in LR, 26 genes were changed significantly.…”

Section: Expression Changes In 5-ht Signaling Pathway Genes In 8 Typementioning

confidence: 99%

Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells

Chang¹,

Yang²,

Zhao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We examined the gene expression profiles of the 5-hydroxytryptamine signaling pathway in the regenerating liver and 8 types of liver cells during rat liver regeneration, and explored expression differences in 5-hydroxytryptamine signaling pathway genes at the level of tissues and cells, as well as the role of the pathway on liver regeneration. Eight types of rat regenerating liver cells were isolated using Percoll density-gradient centrifugation and immunomagnetic bead methods. Rat Genome 230 2.0 Array was used to detect expression changes in 5-hydroxytryptamine signaling pathway genes. The results showed that 26, 47, 8, 21, 16, 19, 22, 27, and 20 effects of 5-hydroxytryptamine signaling pathway genes in 8 types of liver cells showed that 26 genes were expressed significantly; the expression trends of 10 genes were the same in the regenerating liver, while others were different. Based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the RAS and STAT3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the STAT3 signaling pathway, and proliferation and apoptosis of pit cells through the AKT3 signaling pathway. There were large differences in genes involved in 5-hydroxytryptamine signaling at the tissue and cellular levels; thus, liver regeneration should be studied indepth at the cellular level to reveal the molecular mechanism of liver regeneration.

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Dendritic cells, the liver, and transplantation

Cited by 102 publications

References 116 publications

Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells

Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells

Immunology of Liver

Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells

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