Dendritic hybrid materials comprising polyhedral oligomeric silsesquioxane (POSS) and hyperbranched polyglycerol for effective antifungal drug delivery and therapy in systemic candidiasis

Jafari, Mahboobeh; Abolmaali, Samira Sadat; Borandeh, Sedigheh; Najafi, Haniyeh; Zareshahrabadi, Zahra; Koohi-Hosseinabadi, Omid; Azarpira, Negar; Zomorodian, Kamiar; Tamaddon, Ali Mohammad

doi:10.1039/d3nr04321e

Nanoscale

2023

DOI: 10.1039/d3nr04321e

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Dendritic hybrid materials comprising polyhedral oligomeric silsesquioxane (POSS) and hyperbranched polyglycerol for effective antifungal drug delivery and therapy in systemic candidiasis

Mahboobeh Jafari,

Samira Sadat Abolmaali,

Sedigheh Borandeh

et al.

Abstract: Systemic Candida infections are routinely treated with amphotericin B (AMB), a highly effective antimycotic drug.

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2024

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Cited by 3 publications

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Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

Duszczak-Kaczmarek,

Mituła-Chmielowiec,

Rzonsowska

et al. 2024

Sci Rep

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We present a methodology for the synthesis of inorganic-organic Janus-type molecules based on mono-T8 and difunctionalized double-decker silsesquioxanes (DDSQs) via hydrosilylation reactions, achieving exceptionally high yields and selectivities. The synthesized compounds were extensively characterized using various spectroscopic techniques, and their sizes and spatial arrangements were predicted through molecular modelling and density functional theory (DFT) calculations. Quantum chemical calculations were employed to examine the interactions among four molecules of the synthesized compounds. These computational results allowed us to determine the propensity for molecular aggregation, identify the functional groups involved in these interactions, and understand the changes in interatomic distances during aggregation. Understanding the aggregation behaviour of silsesquioxane molecules is crucial for tailoring their properties for specific applications, such as nanocomposites, surface coatings, drug delivery systems, and catalysts. Through a combination of experimental and computational approaches, this study provides valuable insights into the design and optimization of silsesquioxane-based Janus-type molecules for enhanced performance across various fields.

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Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

Duszczak-Kaczmarek,

Mituła-Chmielowiec,

Rzonsowska

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“Clicking” trimeric peptides onto hybrid T₈POSS nanocages and identifying synthesis limitations

Anderson,

Hunter,

Kershaw

et al. 2024

Nanoscale

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Dendrimers—Novel Therapeutic Approaches for Alzheimer’s Disease

Mroziak,

Kozłowski,

Kołodziejczyk

et al. 2024

Biomedicines

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Dendrimers are covalently bonded globular nanostructures that may be used in the treatment of Alzheimer’s disease (AD). Nowadays, AD therapies are focused on improving cognitive functioning and not causal treatment. However, this may change with the use of dendrimers, which are being investigated as a drug-delivery system or as a drug per se. With their ability to inhibit amyloid formation and their anti-tau properties, they are a promising therapeutic option for AD patients. Studies have shown that dendrimers may inhibit amyloid formation in at least two ways: by blocking fibril growth and by breaking already existing fibrils. Neurofibrillary tangles (NFTs) are abnormal filaments built by tau proteins that can be accumulated in the cell, which leads to the loss of cytoskeletal microtubules and tubulin-associated proteins. Cationic phosphorus dendrimers, with their anti-tau properties, can induce the aggregation of tau into amorphous structures. Drug delivery to mitochondria is difficult due to poor transport across biological barriers, such as the inner mitochondrial membrane, which is highly negatively polarized. Dendrimers may be potential nanocarriers and increase mitochondria targeting. Another considered use of dendrimers in AD treatment is as a drug-delivery system, for example, carbamazepine (CBZ) or tacrine. They can also be used to transport siRNA into neuronal tissue and to carry antioxidants and anti-inflammatory drugs to act protectively on the nervous system.

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Dendritic hybrid materials comprising polyhedral oligomeric silsesquioxane (POSS) and hyperbranched polyglycerol for effective antifungal drug delivery and therapy in systemic candidiasis

Abstract: Systemic Candida infections are routinely treated with amphotericin B (AMB), a highly effective antimycotic drug.

Cited by 3 publications

References 51 publications

Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

“Clicking” trimeric peptides onto hybrid T₈POSS nanocages and identifying synthesis limitations

Dendrimers—Novel Therapeutic Approaches for Alzheimer’s Disease

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Dendritic hybrid materials comprising polyhedral oligomeric silsesquioxane (POSS) and hyperbranched polyglycerol for effective antifungal drug delivery and therapy in systemic candidiasis

Abstract: Systemic Candida infections are routinely treated with amphotericin B (AMB), a highly effective antimycotic drug.

Cited by 3 publications

References 51 publications

Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

Preparation of T8 and double-decker silsesquioxane-based Janus-type molecules: molecular modeling and DFT insights

“Clicking” trimeric peptides onto hybrid T8POSS nanocages and identifying synthesis limitations

Dendrimers—Novel Therapeutic Approaches for Alzheimer’s Disease

Contact Info

Product

Resources

About

“Clicking” trimeric peptides onto hybrid T₈POSS nanocages and identifying synthesis limitations