Dendritic, Oligomeric, and Polymeric Self-Immolative Molecular Amplification

Chemical signal activation of an organocatalyst enables control over soft material formation

“…This shows that it is possible to control the moment of material formation in response to a chemical signal. As self-immolative trigger groups allow response to a wide range of signals 12 , we have aimed to develop a generic method for the design of activatable catalysts. Furthermore, since self-immolative molecules can be used to incorporate more than one molecule of interest, the design can be used for signal amplification 12 .…”

“…As self-immolative trigger groups allow response to a wide range of signals 12 , we have aimed to develop a generic method for the design of activatable catalysts. Furthermore, since self-immolative molecules can be used to incorporate more than one molecule of interest, the design can be used for signal amplification 12 . We are currently working on several organocatalysts that are responsive to a range of specific chemical signals.…”

“…This concept provides a generic design to enable autonomous response to biologically and mechanically relevant signals from the environment. The signal responsive catalyst is designed as a self-immolative molecule 12–15 , which fragments upon reaction with a specific chemical signal to release an active catalyst. We synthesise a protected aniline (pro-aniline 1 ) that liberates the organocatalyst aniline 2 upon reaction with the chemical signal H 2 O 2 .…”

A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

“…[25][26][27][28] So far, cellular ROS has never been used as the internal agent to trigger the drug release during which a uorescence turn-on mechanism is utilized to monitor the progress in a real-time mode. When chemically bonded together via a self-immolative BBE linker, 29 the TPE and DOX units are close to each other. Moreover, the emission maximum (480 nm) of TPE is largely over-lapped with the absorption maximum (480 nm) of DOX.…”

Intracellular Photoactivation and Quantification Using Fluorescence Microscopy: Chemical Tools and Imaging Approaches

“…[22] A number of selfimmolative linkers has been developed, mostly based on benzylic eliminations or spontaneous intramolecular cyclization following the release from the protecting group. [22][23][24] Among the probes that exploit selfimmolative linkers and other rearrangements, the three shown in Scheme 2 stand out because, upon release of the molecule of interest, they generate a fluorescent species in a 1:1 stoichiometry. These examples include coumarin derivatives 1 and 2, and cyanine dye 3.…”