Dendritic Polymers in Biomedical Applications: From Potential to Clinical Use in Diagnostics and Therapy

Stiriba, Salah‐Eddine; Frey, Holger; Haag, Rainer

doi:10.1002/1521-3773(20020415)41:8<1329::aid-anie1329>3.0.co;2-p

Cited by 671 publications

(423 citation statements)

References 74 publications

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“…The macromolecule constituents are organized in a branching form from a central core, creating a sphere of chemical end groups at the periphery that can be tailored according to the requirements [2,3], see Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Some new aspects of dendrimer applications

Flomenbom

Amir

Shabat

et al. 2005

Journal of Luminescence

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Dendrimers are characterized by special features that make them promising candidates for many applications. Here we focus on two such applications: dendrimers as light harvesting antennae, and dendrimers as molecular amplifiers, which may serve as novel platforms for drug delivery. Both applications stem from the unique structure of dendrimers. We present a theoretical framework based on the master equation within which we describe these applications. The quantities of interest are the first passage time (FPT) probability density function (PDF), and its moments. We examine how the FPT PDF and its characteristics depend on the geometric and energetic structures of the dendrimeric system. In particular, we investigate the dependence of the FPT properties on the number of generations (dendrimer size), and the system bias. We present analytical expressions for the FPT PDF for very efficient dendrimeric antennae and for dendrimeric amplifiers. For these cases the mean first passage time scales linearly with the system length, and fluctuations around the mean first passage time are negligible for large systems. Relationships of the FPT to light harvesting process for other types of system-bias are discussed.

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Section: Introductionmentioning

confidence: 99%

Some new aspects of dendrimer applications

Flomenbom

Amir

Shabat

et al. 2005

Journal of Luminescence

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“…Dendrimers represented an ideal system for this goal because they possess the same high degree of molecular uniformity as small molecules and the broad theoretical space for chemical tuning as polydisperse polymers (21)(22)(23). These intrinsic characteristics enable dendrimers to have unique properties for various biomedical applications (24)(25)(26). In gene delivery, most studies have used the limited number of commercial dendrimers for further chemical modification (27)(28)(29).…”

mentioning

confidence: 99%

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

Zhou

Nguyen

Miller

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

144

135

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RNA-based cancer therapies are hindered by the lack of delivery vehicles that avoid cancer-induced organ dysfunction, which exacerbates carrier toxicity. We address this issue by reporting modular degradable dendrimers that achieve the required combination of high potency to tumors and low hepatotoxicity to provide a pronounced survival benefit in an aggressive genetic cancer model. More than 1,500 dendrimers were synthesized using sequential, orthogonal reactions where ester degradability was systematically integrated with chemically diversified cores, peripheries, and generations. A lead dendrimer, 5A2-SC8, provided a broad therapeutic window: identified as potent [EC 50 < 0.02 mg/kg siRNA against FVII (siFVII)] in doseresponse experiments, and well tolerated in separate toxicity studies in chronically ill mice bearing MYC-driven tumors (>75 mg/kg dendrimer repeated dosing). Delivery of let-7g microRNA (miRNA) mimic inhibited tumor growth and dramatically extended survival. Efficacy stemmed from a combination of a small RNA with the dendrimer's own negligible toxicity, therefore illuminating an underappreciated complication in treating cancer with RNA-based drugs.dendrimers | miRNA | cancer

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“…Synthetic polymers play a major role in therapeutic drug, protein and gene delivery systems [1][2][3][4][5][6]. Among synthetic polymers (Scheme 1), poly (ethylene glycol) and its derivatives show potential applications in gene and drug delivery due to their solubility, nontoxicity and biocompatibility [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Synthetic Polymers on tRNA Nanoparticle Formation

HA¹

2015

JNMR

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In this review, we have examined the effects of several synthetic nanoparticles such as poly (ethylene glycol) PEG-(PEG-3350, PEG-6000), methoxypoly (ethylene glycol) anthracene (mPEG-anthracene), methoxypoly (ethylene glycol) poly (amidoamine) (mPEG-PAMAM-G3), (mPEG-PAMAM-G4) and poly (amidoamine) (PAMAM-G4) on tRNA structure and dynamics. Atomic force microscopic (AFM) images and spectroscopic data were analysed and the effects of synthetic polymer complexation on tRNA stability, aggregation and particle formation are discussed. Hydrophilic and hydrophobic contacts were dominated in the polymer-tRNA complexation and the overall binding constants showed that the order of binding is PEG-6000>PAMAM-G4>PEG-3350>mPEG-PAMAM-G4>mPEG-PAMAM-G3>mPEG-anthracene. The morphology of polymer-tRNA complexes showed major aggregation and nanoparticle formation of tRNA, in the presence of synthetic nanoparticles.

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Dendritic Polymers in Biomedical Applications: From Potential to Clinical Use in Diagnostics and Therapy

Cited by 671 publications

References 74 publications

Some new aspects of dendrimer applications

Some new aspects of dendrimer applications

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

Effect of Synthetic Polymers on tRNA Nanoparticle Formation

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