Dendritic relationship between starburst amacrine cells and direction‐selective ganglion cells in the rabbit retina

Dong, Wei; Sun, Wenzhi; Zhang, Yingye; Chen, Xiaorong; He, Shunping

doi:10.1113/jphysiol.2004.060715

Cited by 50 publications

(56 citation statements)

References 24 publications

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“…While it is true that the dendrites of α ganglion cells often appear, especially at low power, to run with the cholinergic processes, our analysis showed that this did not occur more than for a randomly oriented cell (see also Dong et al, 2004). In other words, the association of α ganglion cell dendrites with the cholinergic matrix does not exceed that of a random line drawn across the field.…”

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 51%

“…Starburst amacrine cells are relatively numerous wide-field cells with a large overlap producing a dense cholinergic matrix, and it has previously been shown that DS ganglion cells co-fasciculate with the dendrites of starburst amacrine cells. In one model of directional selectivity, it was reported that the null side of DS ganglion cells preferentially associated with starburst amacrine cells (Fried et al, 2002), but in a more recent study, the specificity of these connections could not be confirmed (Dong et al, 2004). Both dendritic trees of ON/OFF DS ganglion cells ran within the cholinergic matrix with no apparent preference for the preferred or null directions.…”

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 88%

“…Most importantly, this was not significantly different for any other orientation. When, one part of the image was rotated out of phase, the degree of overlap was not significantly changed (see also Dong et al, 2004). This indicates that the level of association between α ganglion cells and the cholinergic matrix is merely chance.…”

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 99%

“…Given the sensitivity of the ON/OFF DS ganglion cells to cholinergic drugs, it comes as no surprise that they co-fasciculate with the cholinergic matrix (Famiglietti, 1992;Vaney & Pow, 2000;Dong et al, 2004). The association of ON/OFF DS ganglion cell dendrites with the cholinergic matrix was almost two times higher in the original orientation when compared to a rotated version.…”

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 99%

“…ON/OFF DS ganglion cells (Barlow et al, 1964) are bistratified, exactly coincident with the cholinergic bands in the IPL. (Amthor et al, 1984;Famiglietti, 1992;Vaney & Pow, 2000;Dong et al, 2004). They have branches in both sublamina a and sublamina b and a characteristic retroflexive branching pattern.…”

Section: Introductionmentioning

confidence: 99%

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Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Zhang

Hoshi

et al. 2005

Vis Neurosci

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The correlation between cholinergic sensitivity and the level of stratification for ganglion cells was examined in the rabbit retina. As examples, we have used ON or OFF α ganglion cells and ON/OFF directionally selective (DS) ganglion cells. Nicotine, a cholinergic agonist, depolarized ON/OFF DS ganglion cells and greatly enhanced their firing rates but it had modest excitatory effects on ON or OFF α ganglion cells. As previously reported, we conclude that DS ganglion cells are the most sensitive to cholinergic drugs. Confocal imaging showed that ON/OFF DS ganglion cells ramify precisely at the level of the cholinergic amacrine cell dendrites, and co-fasciculate with the cholinergic matrix of starburst amacrine cells. However, neither ON or OFF α ganglion cells have more than a chance association with the cholinergic matrix. Z-axis reconstruction showed that OFF α ganglion cells stratify just below the cholinergic band in sublamina a while ON α ganglion cells stratify just below cholinergic b. The latter is at the same level as the terminals of calbindin bipolar cells. Thus, the calbindin bipolar cell appears to be a prime candidate to provide the bipolar cell input to ON α ganglion cells in the rabbit retina. We conclude that the precise level of stratification is correlated with the strength of cholinergic input. Alpha ganglion cells receive a weak cholinergic input and they are narrowly stratified just below the cholinergic bands.

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Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 51%

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 88%

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 99%

Section: Co-fasciculation With the Cholinergic Matrixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Zhang

Hoshi

et al. 2005

Vis Neurosci

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Neural control mechanisms of the pheromone‐triggered programmed behavior in male silkmoths revealed by double‐labeling of descending interneurons and a motor neuron

Wada

Kanzaki

2005

J of Comparative Neurology

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Male silkmoths, Bombyx mori, exhibit a characteristic zigzagging behavior consisting of straight-line walking, zigzagging turns, and looping. The timing for shifting the turning direction is synchronized to the sideways head movements controlled by neck motor neurons (NMNs) including a cervical ventral NMN (cv1-NMN). It has been suggested that this programmed behavior is instructed by two types of activity patterns descending from the brain and the thoracic ganglion: one is a phasic excitation and the other is a state-dependent activity similar to the flipflop in electric memory circuits. These activities are shown by certain descending interneurons contained in two subsets of DNs, Group-I and -II DNs. However, it is not yet well understood which DNs are directly related to instructing this behavior. In order to understand neural control mechanisms of this programmed behavior, we investigated the morphological relationship between these DNs and the cv1-NMN, which is an index of this programmed behavior. We applied a double-labeling technique combining backfilling of the cv1-NMN and intracellular staining of single DNs. 3D confocal images revealed overlapping regions between the Group-I, -II DNs and the cv1-NMN. Group-IIA and -IID, which showed typical flipflop activities, Group-IIC DNs, which showed phasic excitation, and Group-IB DNs, which showed long-lasting inhibition had many overlapping regions on the cv1-NMNs. Our results indicate that the programmed behavior is instructed by these types of DNs.

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Development of starburst cholinergic amacrine cells in the retina of Tupaia belangeri

Knabe

Washausen

Happel

et al. 2007

J of Comparative Neurology

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"Starburst" cholinergic amacrines specify the response of direction-selective ganglion cells to image motion. Here, development of cholinergic amacrines was studied in the tree shrew Tupaia belangeri (Scandentia) by immunohistochemistry with antibodies against choline acetyltransferase (ChAT) and neurofilament proteins. Starburst amacrines expressed ChAT much earlier than previously thought. From embryonic day 34 (E34) onward, orthotopic and displaced subpopulations segregated from a single cluster of immunoreactive precursor cells. Orthotopic starburst amacrines rapidly took up positions in the inner nuclear layer. Displaced starburst amacrines were first arranged in a monocellular row in the inner plexiform layer, and, with a delay of 1 week, they descended to the ganglion cell layer. Conversely, dendritic stratification of displaced amacrines slightly preceded that of orthotopic ones. Starburst amacrines expressed the medium-molecular-weight neurofilament protein (NF-M) from E34 to postnatal day 11 (P11) and coexpressed alpha-internexin from E36.5 to P11. Consequently, neurofilaments composed of alpha-internexin and NF-M may stabilize developing dendrites of starburst amacrines. During the first 2 postnatal weeks, subpopulations of anti-NF-M-labeled ganglion cells costratified with the preexisting dendritic strata of starburst amacrines in the ON sublamina, OFF sublamina, or both. Hence, anti-NF-M-labeled ganglion cells may include direction-selective ones. Thereafter, NF-M and alpha-internexin proteins disappeared from starburst amacrines, and NF-M immunoreactivity was lost in the dendrites of ganglion cells. Our findings suggest that NF-M and alpha-internexin are important for starburst amacrines and ganglion cells to recognize each other and, thus, contribute to the formation of early developing retinal circuits in the inner plexiform layer.

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Dendritic relationship between starburst amacrine cells and direction‐selective ganglion cells in the rabbit retina

Cited by 50 publications

References 24 publications

Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Neural control mechanisms of the pheromone‐triggered programmed behavior in male silkmoths revealed by double‐labeling of descending interneurons and a motor neuron

Development of starburst cholinergic amacrine cells in the retina of Tupaia belangeri

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