Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut–brain–ovary axis mechanism

Feng, Xueping; Wang, Decai; Hu, Linlin; Lu, Haishan; ling, Bo; Huang, Yanna; Jiang, Qinyang

doi:10.3389/fendo.2022.962775

Cited by 20 publications

(13 citation statements)

References 54 publications

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“…In addition to the pharmacological effects described above, D. officinale also improves endocrine and metabolic disorders. In rats with letrozole-induced polycystic ovary syndrome, DOP administration can improve steroid hormone disorders through the butyric acid-dependent gut-brain-ovary (GRP41-PYY) axis, promote follicular development, and alleviate polycystic ovary symptoms . In Sjögren’s syndrome mice, DOP inhibited progressive lymphocyte infiltration and apoptosis in mouse cells, balanced pro-inflammatory cytokine disorder in the submandibular gland, improved aquaporin 5 abnormalities, and maintained its functional importance for saliva secretion .…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…In rats with letrozole-induced polycystic ovary syndrome, DOP administration can improve steroid hormone disorders through the butyric acid-dependent gutbrain-ovary (GRP41-PYY) axis, promote follicular development, and alleviate polycystic ovary symptoms. 137 In Sjogren's syndrome mice, DOP inhibited progressive lymphocyte infiltration and apoptosis in mouse cells, balanced pro-inflammatory cytokine disorder in the submandibular gland, improved aquaporin 5 abnormalities, and maintained its functional importance for saliva secretion. 138 In rats with fructose and potassium oxalate-induced hyperuricemia, DoMRE (the macroporous resin extract of D. of f icinale leaves) can enhance uric acid (UA) excretion and decrease UA reabsorption by inhibiting xanthine oxidase activity and regulating the expression of urate transporter 1, glucose transporter 9, and ATP-binding cassette superfamily G member 2.…”

Section: Regulating Gastrointestinalmentioning

confidence: 99%

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Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Zhang,

Zhu

et al. 2023

J. Agric. Food Chem.

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Dendrobium officinale, a plant in the Orchidaceae family, has been used in traditional Chinese medicine for thousands of years. Sweet and slightly cold in nature, it can invigorate the stomach, promote fluid production, nourish Yin, and dissipate heat. Over the past decade, more than 60 compounds have been derived from D. officinale, including flavonoids, bibenzyl, and phenanthrene. Various studies have explored the underlying pharmacological mechanisms of these compounds, which have shown antitumor, hypoglycemic, hypertensive, gastrointestinal-regulatory, visceral organ protection, antiaging, and neurorestorative effects. This paper presents a systematic review of the structural classification, biological activity, and pharmacological mechanisms of different chemical components obtained from D. officinale over the past decade. This review aims to provide a reference for future study and establish a foundation for clinical applications. Furthermore, this review identifies potential shortcomings in current research as well as potential directions and methodologies in future plant research.

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Section: Pharmacological Activitymentioning

confidence: 99%

Section: Regulating Gastrointestinalmentioning

confidence: 99%

Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Zhang,

Zhu

et al. 2023

J. Agric. Food Chem.

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“…Dendrobium officinale Kimura et Migo polysaccharide ameliorates polycystic ovary syndrome via increased butyrate and regulation of G-protein-coupled receptor 41 expression (Feng et al, 2022).…”

Section: Effect Of Polysaccharides On Scfas Which Play a Key Role In ...mentioning

confidence: 99%

“…polysaccharide (APS), a component derived from traditional Chinese medicine, could increase the SCFAs content by regulating the gut microbiota of chronic fatigue syndrome (Wei et al, 2023 ). Dendrobium officinale Kimura et Migo polysaccharide ameliorates polycystic ovary syndrome via increased butyrate and regulation of G‐protein‐coupled receptor 41 expression (Feng et al, 2022 ). Total polysaccharide from Polygonum multiflorum Thunb .…”

Section: Interaction Between Polysaccharides and Gut Microbiotamentioning

confidence: 99%

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Xue,

Mei,

Wang

et al. 2023

Food Science & Nutrition

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Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. A growing number of studies have supported the view that Chinese herbal formula alleviates the symptoms of diarrhea by modulating the fecal microbiota. Chinese herbal polysaccharides (CHPs) are natural polymers composed of monosaccharides that are widely found in Chinese herbs and function as important active ingredients. Commensal gut microbiota has an extensive capacity to utilize CHPs and play a vital role in degrading polysaccharides into short‐chain fatty acids (SCFAs). Many CHPs, as prebiotics, have an antidiarrheal role to promote the growth of beneficial bacteria and inhibit the colonization of pathogenic bacteria. This review systematically summarizes the relationship among gut microbiota, chronic diarrhea, and CHPs as well as recent progress on the impacts of CHPs on the gut microbiota and recent advances on the possible role of CHPs in chronic diarrhea.

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“…History of obesity, most often visceral, worsens insulin sensitivity in approximately 50% of patients [5]. Insulin also increases the activity of cytochrome P450c17, increasing the production of ovarian and adrenal androgens [6].…”

Section: Introductionmentioning

confidence: 99%

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

Semenyna

Фартушок²,

Кomarnitska³

2023

GoS

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Taking into account the importance of correction of metabolic parameters in PCOS, diet therapy is offered. Diet therapy is appropriate as the first stage of treatment in patients with PCOS and IR, but the optimal diet has not been determined at the moment [8]. Purpose: to conduct an analysis of studies on the effectiveness of various types of diet therapy. Materials and methods. 12 articles from 2020 to 2022 were analyzed. Research results and their discussion. A review and analysis of a cohort study on the effects of a ketogenic diet (KD), in which 14 overweight women with a diagnosis of PCOS participated [1].The main argument for the use of KD in PCOS and IR is physiological ketosis [4], which occurs as a result of a low carbohydrate content in the diet, which in turn reduces the level of circulating insulin, and therefore the receptor for insulin-like growth factor type 1. As a result, production of androgens in both ovaries and adrenal glands is inhibited.The results of a 12-week study suggest that a ketogenic diet is appropriate for correcting metabolic disorders and obesity in PCOS and IR.The Mediterranean diet (MED) has proven to be one of the most effective diets in the treatment of metabolic and reproductive problems in women with PCOS and IR [5].The results of the research showed that both approaches to diet therapy are productive in normalizing metabolic processes. It is worth noting that the group of patients who used the MED/LC diet combination showed excellent results in the normalization of the menstrual cycle (86.7% recovered a regular menstrual cycle).Соnclusions. The advantages of KD are a good result in reducing weight and anthropometric indicators in a short period of time. The most promising in the context of PCOS and IR treatment with further introduction into the patients' lifestyle is the Mediterranean diet.

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Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut–brain–ovary axis mechanism

Cited by 20 publications

References 54 publications

Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

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