Dendronized iron oxide nanoparticles as contrast agents for MRI

Basly, Brice; Felder‐Flesch, Delphine; Perriat, Pascal; Billotey, Claire; Taleb, Jacqueline; Pourroy, G.; Bégin‐Colin, Sylvie

doi:10.1039/b920348f

Cited by 120 publications

(120 citation statements)

References 41 publications

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“…Finally, these superparamagnetic iron oxide based NPs need to be stabilized under physiological conditions by chemical modification of their surface. Different electrostatic agents such as citric acid [7], DMSA [8], phosphonates [9] or steric agents like PEG [10] or dextran [11] are usually used.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal synthesis of fine stabilized superparamagnetic nanoparticles of Zn2+ substituted manganese ferrite

Zahraei

Monshi

Morales

et al. 2015

Journal of Magnetism and Magnetic Materials

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Section: Introductionmentioning

confidence: 99%

Hydrothermal synthesis of fine stabilized superparamagnetic nanoparticles of Zn2+ substituted manganese ferrite

Zahraei

Monshi

Morales

et al. 2015

Journal of Magnetism and Magnetic Materials

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“…26 Naturally, anchors that meet these stringent requirements can be used both to immobilize initiators on a surface to graft dispersants from NP surfaces and to graft polymer brushes to NP surfaces. Typical anchors to surface modify superparamagnetic iron oxide NPs described in the literature are catechols [66][67][68][69] or catechol derivatives, 22,23,70,71 carboxy groups, [72][73][74] phosphonates 73,75,76 and silanes. [77][78][79][80][81] Superparamagnetic iron oxide NPs individually stabilized with these dispersants are increasingly used for numerous biomedical applications (Table 1 and Fig.…”

Section: Anchorsmentioning

confidence: 99%

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

2011

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Superparamagnetic iron oxide nanoparticles (NPs) are used in a rapidly expanding number of research and practical applications in the biomedical field, including magnetic cell labeling separation and tracking, for therapeutic purposes in hyperthermia and drug delivery, and for diagnostic purposes, e.g., as contrast agents for magnetic resonance imaging. These applications require good NP stability at physiological conditions, close control over NP size and controlled surface presentation of functionalities. This review is focused on different aspects of the stability of superparamagnetic iron oxide NPs, from its practical definition to its implementation by molecular design of the dispersant shell around the iron oxide core and further on to its influence on the magnetic properties of the superparamagnetic iron oxide NPs. Special attention is given to the selection of molecular anchors for the dispersant shell, because of their importance to ensure colloidal and functional stability of sterically stabilized superparamagnetic iron oxide NPs. We further detail how dispersants have been optimized to gain close control over iron oxide NP stability, size and functionalities by independently considering the influences of anchors and the attached sterically repulsive polymer brushes. A critical evaluation of different strategies to stabilize and functionalize core-shell superparamagnetic iron oxide NPs as well as a brief introduction to characterization methods to compare those strategies is given.

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“…Although higher values for r 2 have been reported [46], in the present work the ratio r 2 /r 1 is outstanding high, due to the extremely low r 1 values. For comparison, in Table 2 the r 1 , r 2 and r 2 /r 1 for a commercial CA based on SPIONs (obtained also at 7 T) are presented [47]. To the best of our knowledge the r 2 /r 1 ratios presented here for the first time, in particular at 7T, are the highest observed yet.…”

Section: Nuclear Magnetic Relaxivitiesmentioning

confidence: 68%

“…NPs-GPTMS NPs-TEOS d (nm) 96.6 ± 9.6 22.0 ± 2.2 66.6 ± 6.6 Table 2 Longitudinal and transverse relaxivities and r 2 /r 1 ratio for the coreeshell NPs measured at a 7 T magnetic field and for Endorem a commercial CA [47] In Fig. 6, longitudinal and axial slices of zebra-fish injected with coreeshell NPs-APTES are shown.…”

Section: Nps-aptesmentioning

confidence: 99%

Core–shell superparamagnetic nanoparticles with interesting properties as contrast agents for MRI

Carvalho

Domingues

Gonçalves

2015

Materials Chemistry and Physics

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h i g h l i g h t sCoreeshell nanoparticles with iron oxide cores and different coatings were obtained. The new nanosystems are efficient as negative contrast agent for MRI. The efficiency is discussed relating to the different coatings properties. Contrast enhancement is quantified in phantoms MRI and validated in an animal model. The potentiality of these new coreeshell NPs as negative CA for MRI is demonstrated and quantified. The longitudinal and transverse relaxivities of NPs with three different coating compositions were studied at a 7 T magnetic field: silica (TEOS), (3-aminopropyl) triethoxysilane (APTES) and (3-glycidoxypropyl) methyldiethoxysilane (GPTMS).Clearly, it was found that the coreeshell NPs efficiency as CA was strongly depend on the SPIONs coating.All the three coreeshell NPs studied presented a very small effect on the longitudinal relaxation time but a pronounced one on the transverse relaxation time, leading to a very high transverse longitudinal relaxivities ratio, decisive for their efficiency as negative CA for MRI.The effect of the coreeshell NPs on the MRI contrast enhancement is obtained and quantified in a set of MRI of agar phantoms obtained at 7 T magnetic field and with a imaging gradient field of 1.6 T/m. The coreeshell NPs were tested in Zebra-fish (Danio rerio) animal model. Zebra-fish MRI were obtained with animals injected with the three coreeshell NPs and the contrast enhancement validated.

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Dendronized iron oxide nanoparticles as contrast agents for MRI

Abstract: Covalent attachment, through a phosphonate anchor, of hydrophilic pegylated dendrons on iron oxide nanoparticles results in versatile, robust, and highly relaxing MRI contrast agents.

Cited by 120 publications

References 41 publications

Hydrothermal synthesis of fine stabilized superparamagnetic nanoparticles of Zn2+ substituted manganese ferrite

Hydrothermal synthesis of fine stabilized superparamagnetic nanoparticles of Zn2+ substituted manganese ferrite

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

Core–shell superparamagnetic nanoparticles with interesting properties as contrast agents for MRI

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