Dengue fever is an emerging public health concern in the city of Multan, Pakistan: its seroprevalence and associated risk factors

Mukhtar, Muhammad Uzair; Mukhtar, Maria; Iqbal, Naveed

doi:10.1111/1348-0421.12649

Cited by 3 publications

(6 citation statements)

References 21 publications

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“…We found the sero-prevalence of DENV IgM among febrile patients is higher (45%) than IgG (4.2%). The results are in agreement with findings described in Tanzania [15], Kenya [16], Eastern India [17], Brazil [18], Singapore [19], and Southern Pakistan [12], where DENV IgG was reported to be between 4.5% to 12%. In contrast, the prevalence of anti-DENV IgG seropositivity in the present study was lower than the rates in South Ethiopia [20], Djibouti [21], and the northern province of Sudan [22], where it was reported to be between 20-24%.…”

Section: Discussionsupporting

confidence: 92%

“…However, fewer cases were noted in dry months also, illustrating that despite an epidemic profile, transmission persists in Sheikhupura in wet and dry seasons. There was also a significant correlation between DENV and environmental factors such as rainfall, temperature, and humidity, which is consistent with the conclusion in Myanmar [24], Brazil [18], Venezuela [25], India [17], China [26], Nepal [27], and Pakistan [12].…”

Section: Discussionsupporting

confidence: 88%

“…The study disclosed that dengue is predominant in men in Sheikhupura, and most cases appear in individuals aged between 11 and 30 years. These findings are persistent with gender-specific DENV cases published in Malaysia [28], Thailand [29], Singapore [19], Pakistan [12], Nicaragua [30], Japan, and Korea [31]. Our analysis found a significant relationship between gender, age, and exposure to dengue, which is related to the pattern of human occupation and cultural trends in the study area.…”

Section: Discussionsupporting

confidence: 79%

“…Previously, studies reported the dengue epidemic in Peshawar [11] and Multan [12] in Pakistan. Earlier, dengue got documented from Sheikhupura's neighbouring city of Lahore [13] but, no report surfaced from Sheikhupura.…”

Section: Introductionmentioning

confidence: 99%

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The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

Mukhtar

Mukhtar²,

Iqbal

et al. 2021

J Infect Dev Ctries

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Introduction: District Sheikhupura encountered its first dengue outbreak in 2014 but lacked serological evidence and reports of risk factors associated with it. To assess this, a hospital-based study was conducted from January 2014 to December 2017. Methodology: Blood from 333 participants was collected, the serum obtained was tested for IgG and IgM antibodies against DENV using a commercially available ELISA kit. Results: The results showed that out of all (n= 333) samples tested, 120 were turned up positive for DENV, making an overall prevalence of 36%. Of the 120 confirmed cases, 55% (n = 66) were recorded in 2014, 10% (n = 12) in 2015, 27.5% (n = 33) in 2016, and 7.5% (n = 9) in 2017. It was found that 68.3% (n = 82) were male and 31.7% (n = 38) were female, with 61% (n = 74) patients aged between 11-30 years. The highest prevalence of infection, 94.2% (n = 113), was noted after the rainy season. During the study, the highest number of cases appeared in Ferozewala Tehsil. The factors age, gender, and season were found statistically significant with the prevalence of infection (p < 0.05). Conclusions: The study is the first report on the detection of dengue in the Sheikhupura district. The survey anticipated its geographical expansion, determined associated risk factors, and suggests active disease surveillance in the area.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

Mukhtar

Mukhtar²,

Iqbal

et al. 2021

J Infect Dev Ctries

Self Cite

View full text Add to dashboard Cite

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“…The data are so varied that a difference is even found within a specific city, one example being Singapore. 51,[53][54][55][56][57][58] The literature does not support that greater incidence in children and male individuals is a defined characteristic of dengue. Such contrast demonstrates the importance of local factors that might contribute greater to disease incidence, such as transmission intensity, local herd immunity, and temporal patterns.…”

Section: Discussionmentioning

confidence: 99%

Surveillance and Epidemiology of Dengue in Medellín, Colombia from 2009 to 2017

Warnes

Santacruz-Sanmartín

Carrillo

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Dengue is the most prevalent arthropod-borne viral disease in humans, primarily transmitted by the Aedes aegypti mosquito. We conducted a descriptive analysis of dengue cases from 2009 to 2017 in Medellín, Colombia, using data available from the Secretariat of Health. We analyzed the burden of outbreak years on the healthcare system, risk of cases exhibiting severe illness, potential disease surveillance problems, gender and age as risk factors, and spatiotemporal patterns of disease occurrence. Our data consisted of 50,083 cases, separated based on whether they were diagnostic test negative, diagnostic test positive (primarily IgM ELISA), clinically confirmed, epidemiologically linked, or probable. We used dengue incidence to analyze epidemiological trends between our study years, related to human movement patterns, between gender and age-groups, and spatiotemporally. We used risk to analyze the severity of dengue cases between the study years. We identified human movement could contributed to dengue spread, and male individuals (incidence rate: 0.86; 95% CI: 0.76–0.96) and individuals younger than 15 years (incidence rate: 1.24; 95% CI: 1.13–1.34) have higher incidence of dengue and located critical parts of the city where dengue incidence was high. Analysis was limited by participant diagnostic information, data concerning circulating strains, and a lack of phylogenetic information. Understanding the characteristics of dengue is a fundamental part of improving the health outcomes of at-risk populations. This analysis will be useful to support studies and initiatives to counteract dengue and provide context to the surveillance data collected by the health authorities in Medellín.

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Integrating Spatial Modelling and Space–Time Pattern Mining Analytics for Vector Disease-Related Health Perspectives: A Case of Dengue Fever in Pakistan

Naqvi

Sajjad

Waseem

et al. 2021

IJERPH

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The spatial–temporal assessment of vector diseases is imperative to design effective action plans and establish preventive strategies. Therefore, such assessments have potential public health planning-related implications. In this context, we here propose an integrated spatial disease evaluation (I-SpaDE) framework. The I-SpaDE integrates various techniques such as the Kernel Density Estimation, the Optimized Hot Spot Analysis, space–time assessment and prediction, and the Geographically Weighted Regression (GWR). It makes it possible to systematically assess the disease concentrations, patterns/trends, clustering, prediction dynamics, and spatially varying relationships between disease and different associated factors. To demonstrate the applicability and effectiveness of the I-SpaDE, we apply it in the second largest city of Pakistan, namely Lahore, using Dengue Fever (DF) during 2007–2016 as an example vector disease. The most significant clustering is evident during the years 2007–2008, 2010–2011, 2013, and 2016. Mostly, the clusters are found within the city’s central functional area. The prediction analysis shows an inclination of DF distribution from less to more urbanized areas. The results from the GWR show that among various socio-ecological factors, the temperature is the most significantly associated with the DF followed by vegetation and built-up area. While the results are important to understand the DF situation in the study area and have useful implications for public health planning, the proposed framework is flexible, replicable, and robust to be utilized in other similar regions, particularly in developing countries in the tropics and sub-tropics.

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Dengue fever is an emerging public health concern in the city of Multan, Pakistan: its seroprevalence and associated risk factors

Cited by 3 publications

References 21 publications

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

Surveillance and Epidemiology of Dengue in Medellín, Colombia from 2009 to 2017

Integrating Spatial Modelling and Space–Time Pattern Mining Analytics for Vector Disease-Related Health Perspectives: A Case of Dengue Fever in Pakistan

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