Dengue NS1 Antigen: A Tool in Early Detection of Dengue Virus Infection

Biswas, Rama; Mohammed, Fazle Rabbi; Sengupta, Poly; Ahmed, Hasan Shahrear; Rahman, Md. Motlabur; Sarker, Mohammad Abdus Sattar; Nazimuddin, Mirza

doi:10.3329/jom.v15i1.19856

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Dengue fever (DF) is an arthropod-borne viral disease that affects over 100 million cases worldwide [1,2]. Bangladesh is a country that is most adversely affected by dengue almost every year [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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Background The clinical presentation of dengue fever had been observed to change with time since its first outbreak in 2000 in Bangladesh. This report showed the clinical presentation of the 2019 outbreak in Bangladesh along with its comparison to previous outbreaks witnessed in this region. Methods This hospital-based cross-sectional study was conducted in one of the largest tertiary care hospitals in Dhaka city. A total of 553 laboratory-confirmed and 194 probable dengue cases were interviewed. The clinical manifestation of the confirmed cases of the current outbreak was compared with three of the outbreak reports retrieved from the databases. R version 3.6.3 was used for data analysis. Results Among the confirmed cases, two-thirds were male (63.2%) and the average age was 27(± 11) years. Positive tests for NS1 and IgM were present in 99.6% (n = 525/527) and 82.6% (n = 38/46) of the cases, respectively. Thrombocytopenia was present in 66.1% of cases. Fever (100%) was common for all. Gastrointestinal (GIT) features, including abdominal pain (86.5%), anorexia and/or vomiting (69.6%), and Diarrhea (> 3 motions/day) (26.2%) were more frequent than typical rash and other pain symptoms. Hypotension was present in approximately a quarter of patients (25%). GIT features (anorexia, nausea, and/or vomiting) and hypotension were more common among adult participants while bleeding manifestation (melena and vaginal bleeding, p = 0.009 & 0.032) was more frequent in pediatric patients. Compared to outbreaks of 2008, 2016, and 2018, increasing trends in GIT symptoms e.g. anorexia, abdominal pain, and diarrhea were observed. While a negative trend in hemorrhagic manifestations (skin rash, melena, and conjunctival hemorrhage/hemorrhagic sclera) and arthralgia/joint pain were found. Conclusion The present outbreak was noticeably characterized by GIT symptoms and hypotension in addition to the typical clinical features like rash and pain symptoms. An increasing trend in GIT features and decreasing trend in hemorrhagic manifestations was noted over the last decade of dengue outbreaks.

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Section: Introductionmentioning

confidence: 99%

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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“…In this study, the male percentage (70%) was higher than the female percentage (30%) (Fig: 2). Similarly, the male ratio was higher in Barisal but inhabitant frequency is unknown to us in the case of Dhaka dengue outbreak (25,26). Global studies also showed male ratio is higher than females.…”

Section: Resultsmentioning

confidence: 90%

Recent Trends of Dengue Virus Infection in Dhaka, Bangladesh

et al. 2022

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The disease caused by the Dengue virus (DENV), belongs to the Flaviviridae family, which is the most common vector for transmission of the virus between humans and arthropods Aedes aegypti mosquitoes. In recent years, the number of dengue cases has increased drastically throughout the world, according to a survey around 390 million dengue infection cases are recorded annually, among which one-fourth of cases show clinical manifestations. In Bangladesh, dengue outbreaks are on the increasing trend despite the efforts to control this disease A Hospital-based study of dengue patients in Dhaka city was conducted to check the recent trends of dengue infection among the inhabitants of Dhaka, Bangladesh. 89 blood samples from different patients with appropriate symptoms were tested using the Dengue NS1 Quanticard kit. Among samples, 60 (68%) samples were tested as positive whereas 22 (25%) showed negative results and 6 (7%) showed invalid results in tests. Despite the testing of a low number of samples, it can be clearly stated that a large number of positive results was observed with specific symptoms commonly found in Dengue infection. Among all the positive results some (7%) of the patients did not show any signs and symptoms, but after testing the results were positive against the viral antigen. Attempt to increase awareness about dengue fever through effective management measures from the government and NGOs are very much needed. Stamford Journal of Microbiology, Vol.12 (1) 2022: 43-46

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Clinico-epidemiologic characteristics of the 2019 dengue outbreak in Bangladesh

Hasan¹,

Tabassum²,

Sharif

et al. 2020

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Dengue fever shows a broad range of clinical presentations worldwide. Here we report on our clinical findings during the 2019 dengue outbreak in one of the largest tertiary care hospitals in Dhaka, the capital of Bangladesh. Methods A total of 747 suspected dengue cases (553 confirmed and 194 probable) were interviewed with a pro forma case record form. Statistical analyses were conducted using SPSS 20.0. Ethical clearance was obtained from the Dhaka Medical College. Results The mean age of the dengue cases was 27 y and approximately two-thirds were male. Positive tests for NS1 and anti-dengue immunoglobulin M antibody were present in 91.9% and 59.4% of the cases, respectively. Thrombocytopenia was present in 69% of cases and fever was present in 99.1% of cases. Gastrointestinal (GI) features, including anorexia and/or vomiting (69.4%), abdominal pain (39.8%) and diarrhoea (25.6%), were more prevalent than typical rash and pain symptoms. Hypotension was present in approximately one-quarter of patients (25.4%). Probable and confirmed dengue cases have shown similar clinical characteristics and laboratory findings. Conclusions The 2019 outbreak of dengue fever in Bangladesh was characterized by increased presentation with GI features. Recognition of this trend would permit early diagnosis and proper management of patients.

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Dengue NS1 Antigen: A Tool in Early Detection of Dengue Virus Infection

Cited by 6 publications

References 7 publications

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Recent Trends of Dengue Virus Infection in Dhaka, Bangladesh

Clinico-epidemiologic characteristics of the 2019 dengue outbreak in Bangladesh

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