Dengue Research Opportunities in the Americas

Laughlin, Catherine A.; Morens, David M.; Cassetti, M. Cristina; Denis, Adriana Costero-Saint; Martin, J San; Whitehead, Stephen S.; Fauci, Anthony S.

doi:10.1093/infdis/jis351

Cited by 68 publications

(50 citation statements)

References 49 publications

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“…The prevention strategies tried thus farpublic health measures, mosquito control, and vaccine development-have not been entirely successful. A recent international workshop concluded that the best hope for better prevention and control of dengue is an integrated cross-disciplinary approach involving basic science, public health, vector control, ecology, and many other disciplines (Laughlin et al 2012). Clearly, dengue is not just a simple re-emerging infectious disease; rather, it is a product of complex ecosystem imbalance.…”

Section: Discussionmentioning

confidence: 99%

“…Dengue was not a new disease in 1780; rather it was newly recognized. In retrospect, dengue epidemics probably occurred in the Caribbean islands at least as early as 1635, when Jean-Baptiste du Tertre reported outbreaks of coup de barre (beating with a stick'' (du Tertre 1667; Laughlin et al 2012)). …”

Section: The Origins Of Denguementioning

confidence: 99%

“…Several are under preclinical and clinical development (Laughlin et al 2012;Murphy and Whitehead 2011), but the challenge of making a tetravalent vaccine that cannot enhance natural infection is daunting: the potential for immunopathologic complications and the criteria for assessing the safety of such a vaccine when used in open populations highly exposed to natural infections are both undetermined.…”

Section: Dengue Vaccinesmentioning

confidence: 99%

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Dengue: The Continual Re-Emergence of a Centuries-Old Disease

2013

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Section: Discussionmentioning

confidence: 99%

Section: The Origins Of Denguementioning

confidence: 99%

Section: Dengue Vaccinesmentioning

confidence: 99%

See 1 more Smart Citation

Dengue: The Continual Re-Emergence of a Centuries-Old Disease

2013

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“…Aegypti and Ae. albopictus the main vectors in the Americas and Asia respectively [1,2]. An estimated 2.5 million people live at risk and the incidence of the disease is between 50 to 100 million cases/year, with an increasing trend due to the wide geographical spread of the virus and its vector [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Detection of Dengue Virus in Department of Bolivar, Colombia, 2012-2013, Real-Time PCR

Gómez

García

Ochoa

et al. 2013

JBT

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Objective. To assess the presence of RNA from dengue virus by Real Time Polymerase Chain Reaction with Reverse Transcriptase (qRT-PCR), in anti-dengue IgM seronegative serum samples obtained from symptomatic patients with less than 5 days of fever, in the department of Bolivar, Colombia. Materials and Methods.Cross sectional descriptive study, where 50 anti-dengue IgM seronegative serum samples were analyzed by qRT-PCR. In addition, we reviewed the epidemiological charts of each patient in order to collect sociodemographic and blood count (CBC) data.Results. DENV-3 RNA was detected in seven (14 %) serum samples. The most common clinical manifestations were: fever (90 %; 45/50), headache (88 %; 44/50) and myalgia (74 %; 37/50). Regarding the CBC, the most significant findings were: thrombocytopenia (60 %; 30/50; 73.3% were men), and leukopenia (50 %; 25/50; 60% were men). Conclusion.Detection and typing of DENV genome by qRT-PCR could be considered a diagnostic tool for Dengue in anti-dengue IgM seronegative serum samples, especially, within four days after the onset of the signs of the disease.

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“…4 Current research has centered on using protein and nucleic acid detection technologies on patient blood specimens to discover and identify early-onset biomarker/biomarker panel that reliably predict the progress into severe manifestation. 9 Moreover, because secondary infection with another dengue serotype increases the risk of developing more severe forms of the diseases, 31 developing assays to accurately differentiate primary and secondary dengue infection will assist in predicting the severity of disease and could permit for better patient management. …”

mentioning

confidence: 99%