Dengue Virus in Bats from Córdoba and Sucre, Colombia

Calderón, Alfonso; Guzmán, Camilo; Máttar, Salim; Rodríguez, Virginia; Martínez, Caty; Violet, Lina; Martínez, Jairo; Figueiredo, Luíz Tadeu Moraes

doi:10.1089/vbz.2018.2324

Cited by 21 publications

(10 citation statements)

References 34 publications

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“…There are four DENV serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that can cause febrile syndromes in humans. Dengue fever is recognized as an epidemic re-emerging disease that has affected many countries in recent decades ( Zambrano et al, 2017 , Wilder-Smith et al, 2019 , Lorenz et al, 2020 , Zambrano et al, 2019 , Calderon et al, 2019b ).…”

Section: Role Of Bats In the Origin Of Emerging And Re-emerging Infecmentioning

confidence: 99%

“…Recently in Colombia, viral RNA was obtained from bat tissues, and a nested-RT-PCR detected amplicons of 143 fragment of the NS5 gene that were then sequenced by the Sanger method. In non-hematophagous bats such as Carollia perspicillata and Phyllostomus discolor captured in Ayapel and San Carlos (Córdoba) respectively, an amplicon corresponding to NS5 was detected; these amplicons showed high similarity with DENV-2 ( Calderon et al, 2019b ). Yet, the clinical relevance of DENV isolation from bats is unclear, as well as the implications in transmission to humans.…”

Section: Role Of Bats In the Origin Of Emerging And Re-emerging Infecmentioning

confidence: 99%

See 1 more Smart Citation

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

Bonilla-Aldana¹,

Jimenez-Diaz²,

Arango-Duque³

et al. 2021

International Journal of Infectious Diseases

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Highlights Bats serve as natural reservoirs for a variety of viruses. Transmission of highly pathogenic viruses from bats has been suspected and linked to a spectrum of emerging infectious diseases in humans and animals worldwide. Examples of such viruses include Marburg, Ebola, Nipah, Hendra, Influenza A, Dengue, Equine Encephalitis viruses, Lyssaviruses, Madariaga and Coronaviruses, involving the now pandemic Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we provide a comprehensive review on the diversity, reservoirs, and geographical distribution of the main bat viruses and their potential for cross-species transmission.

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Section: Role Of Bats In the Origin Of Emerging And Re-emerging Infecmentioning

confidence: 99%

Section: Role Of Bats In the Origin Of Emerging And Re-emerging Infecmentioning

confidence: 99%

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

Bonilla-Aldana¹,

Jimenez-Diaz²,

Arango-Duque³

et al. 2021

International Journal of Infectious Diseases

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“… [ 57 ] Bats Costa Rica Puntarenas & Liberia Urban/rural 1998 12/53 (22.6); D1,2 PRNT; Tested for D1/2/3/4 Active outbreaks of dengue, all 4 serotypes have be isolated in the past 6 years of the study. [ 49 ] Ecuador Tena 3/10 (30); D2,3 Unknown Bats Mexico Cuitzmala River Basin, Jalisco Forest 2014 0/83 (Tested against flavivirus; NS5) DENV reported in humans [ 59 ] Bats Brazil São Jose ´ do Rio Preto, São Paulo State Urban/rural 2014–2017 0/64 (Tested against flavivirus; NS5) 0/46 HI; Tested for D1/2/3/4 High incidence of arbovirus infection in humans [ 50 ] Barreiras, Bahia State 0/39 (Tested against flavivirus; NS5) 0/27 Known occurrences of DENV Bats Columbia San Carlos & Ayapel , Córdoba & Sucre Urban/rural Before 2019 2/286 (0.7); D2 (NS5)* [ 45 ] Bats Singapore Unknown Urban/rural Before 2019 14/106 (13.2); D2 (NS1) Luciferase LIPS; Tested for D2 NS1 antigen only [ 54 ] Bats Australia Townsville, Northern Queensland Urban/rural 1954 4/17 (23.5); D1 Mouse protection test; Tested for D1 only Extensive epidemic from Dec 1953 – Mar 1954, sporadic cases from Dec 1954 – Nov 1955. …”

Section: Resultsmentioning

confidence: 99%

“…Among the urban/rural setting where bats were captured, there were 13.1% (136/1036) of bats that were dengue positive by serology while no bats (0/91) captured in the forest setting was positive by serology ( p < 0.05). There were 14 studies involving the urban/rural setting [ [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] ], 4 involving the forest setting [ 44 , 52 , 58 , 59 ]. Of which, 12 and 2 studies respectively were based in those settings exclusively.…”

Section: Resultsmentioning

confidence: 99%

Animals as potential reservoirs for dengue transmission: A systematic review

et al. 2021

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Dengue is a rapidly spreading mosquito-borne flavivirus infection that is prevalent in tropical and sub-tropical regions. Humans are known to be the main reservoir host maintaining the epidemic cycles of dengue but it is unclear if dengue virus is also maintained in a similar enzootic cycle. The systematic review was conducted in accordance to Cochrane's PRISMA recommendations. A search was done on PubMed, EMBASE, Scopus and Cochrane Library. Key data on animal dengue positivity was extracted and classified according to animal type and diagnostic modes. Of the 3818 articles identified, 56 articles were used in this review. A total of 16,333 animals were tested, 1817 of which were positive for dengue virus by RT-PCR or serology. Dengue positivity was detected in bats (10.1%), non-human primates (27.3%), birds (11%), bovid (4.1%), dogs (1.6%), horses (5.1%), pigs (34.1%), rodents (3.5%), marsupials (13%) and other small animals (7.3%). While majority of dengue positivity via serology suggests potential enzootic transmission, but regular dengue virus spillback cannot be excluded. With the exception of bats, acute infection among animals is limited. Further investigation on animals is critically required to better understand their role as potential reservoir in dengue transmission.

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“…Currently, DENV 1, 2, 3, and 4 are all fostering alternated or simultaneous epidemics in different regions of Brazil. Regarding the sylvatic maintenance cycles, DENV 1-4 were reported to have infected neotropical forest mammals such as rodents, marsupials, and bats, in French Guyana (Thoisy et al, 2009), and in the Caribbean region of Colombia, and DENV-2 was reported infecting bats ( Carollia perspicillata and Phyllostomus discolor ) (Calderón et al, 2019). In Brazil, Aedes albopictus , a species of mosquito that frequently inhabits the backyards of human houses but easily spreads into rural, semi-rural, and wild environments, has been found infected with DENV-3 in São Paulo State.…”

mentioning

confidence: 99%

Human Urban Arboviruses Can Infect Wild Animals and Jump to Sylvatic Maintenance Cycles in South America

Figueiredo

2019

Front. Cell. Infect. Microbiol.

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The present study shows that the most prominent human arboviruses worldwide (dengue viruses 1, 2, 3, and 4, Chikungunya virus, and Zika virus) can infect wild animals and transfer from urban to sylvatic maintenance cycles in South America, as did the yellow fever virus (YFV) in the past. All these viruses are transmitted by the anthropophilic mosquito Aedes aegypti and cause epidemics throughout Brazil. The YFV is the oldest example of an urban arbovirus that became sylvatic in South America. Currently, the disease is a zoonosis of non-human primates that moves like a wave through the forests of the Brazilian countryside, traveling thousands of kilometers, killing many animals and eventually infecting man. However, since 2016, this zoonotic wave has reached the highly populated areas of Southeast Brazil, producing the largest human outbreak in the past 60 years. As with the YFV, sylvatic cycles may occur with dengue, Chikungunya, and Zika. In order to become sylvatic, arboviruses require an apparently unlikely conjunction of factors to unexpectedly take place. These arboviruses could start to infect sylvatic primates and be transmitted by Haemagogus mosquitoes that inhabit tree canopies. We mention here publications reporting evidence of sylvatic cycles of dengue, Chikungunya, and Zika virus in South America. Indeed, it is almost unfeasible to control these cycles of arboviruses since it is impossible to know where, when or why an arboviral spill-over would occur in wild animals. The sylvatic maintenance cycle could preclude the eradication of an arbovirus. Moreover, an arbovirus in a sylvatic cycle could re-emerge anytime, infecting humans and producing outbreaks. In case of the reemergence of an arbovirus, it is crucial to prevent the occurrence of an urban cycle as a spill-back from the sylvatic cycle.

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Dengue Virus in Bats from Córdoba and Sucre, Colombia

Cited by 21 publications

References 34 publications

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

Animals as potential reservoirs for dengue transmission: A systematic review

Human Urban Arboviruses Can Infect Wild Animals and Jump to Sylvatic Maintenance Cycles in South America

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