Deniz Makroalgi Codium fragile (Suringar) Hariot ’in Kimyasal Bileşimi, In-Vitro Antimikrobiyal ve Antioksidan Aktivitelerinin Analizi

Keskinkaya, Hatice Banu; Deveci, Ebru; Güneş, Erdoğan; Okudan, Emine Şükran; Akköz, Cengiz; Gümüş, Numan Emre; Karakurt, Serdar

doi:10.31594/commagene.1084336

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Therefore, to estimate the protective effects of Codium fragile against PM 2.5 -induced oxidative stress, SOD activities, reduced GSH contents, and MDA levels were estimated in lung tissues ( Figure 3 ). According to a previous study, Codium fragile contains various flavonoid compounds such as naringenin, kaempferol, catechin, and epicatechin with considerable antioxidant activities [ 11 ]. Administration of these flavonoids had significant protective effects against oxidative stress-induced cytotoxicity in the systemic antioxidant system [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Codium fragile , a marine green alga belonging to the family Codiaceae , is cultivated and used for food in various countries such as the Republic of Korea, China, and Japan, and in North America [ 10 ]. Codium fragile contains various bioactive phenolic compounds, such as salicylic acid, p-coumaric acid, tamarixetin, morin, naringenin, kaempferol, and quercetin, and polysaccharides such as sulfated galactan [ 11 ]. It also has been reported that Codium fragile shows bioactive activities such as antioxidant activity, anti-diabetes, osteoarthritis inhibitory effect, hepato-protective effect, and anti-inflammatory effect [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Codium fragile Suppressed Chronic PM2.5-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice

Kim,

Lee

et al. 2023

Antioxidants

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This study investigated the ameliorating effect of the aqueous extract of Codium fragile on PM2.5-induced pulmonary dysfunction. The major compounds of Codium fragile were identified as palmitic acid, stearic acid, and oleamide using GC/MS2 and hexadecanamide, oleamide, and 13-docosenamide using UPLC-Q-TOF/MSE. Codium fragile improved pulmonary antioxidant system deficit by regulating SOD activities and reducing GSH levels and MDA contents. It suppressed pulmonary mitochondrial dysfunction by regulating ROS contents and mitochondrial membrane potential levels. It regulated the inflammatory protein levels of TLR4, MyD88, p-JNK, p-NF-κB, iNOS, Caspase-1, TNF-α, and IL-1β. In addition, it improved the apoptotic protein expression of BCl-2, BAX, and Caspase-3 and attenuated the fibrous protein expression of TGF-β1, p-Smad-2, p-Smad-3, MMP-1, and MMP-2. In conclusion, this study suggests that Codium fragile might be a potential material for functional food or pharmaceuticals to improve lung damage by regulating oxidative stress inflammation, cytotoxicity, and fibrosis via the TLR/TGF-β1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Codium fragile Suppressed Chronic PM2.5-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice

Kim,

Lee

et al. 2023

Antioxidants

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“…In a previous study, AECF showed protection of the HT22 and BV-2 cells by increasing the cell viability and decreasing ROS production against PM 2.5 -induced cytotoxicity [ 14 ]. It has been reported that Codium fragile contains various compounds with physiological activities such as gallic acid, 4-hydroxbenzaldehyde, 4-hydroxybenzoic acid, p -coumaric acid, and salicylic acid [ 28 ]. Gallic acid significantly improved the level of antioxidant enzymes in the body such as CAT, SOD, and glutathione peroxidase and decreased the content of MDA [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Codium fragile Suppresses PM2.5-Induced Cognitive Dysfunction by Regulating Gut–Brain Axis via TLR-4/MyD88 Pathway

Kim,

Lee

et al. 2023

IJMS

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This study was conducted to evaluate the cognitive dysfunction improvement effect of aqueous extract of Codium fragile (AECF) by regulating the imbalance of the gut–brain axis in chronic particulate matter (PM)2.5-exposed mice. The physiological compounds of AECF were identified as hexadecanamide, oleamide, octadecanamide, stearidonic acid, and linolenic acid by the ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC Q-TOF MSE) analysis. To evaluate the effect of PM2.5 on the antioxidant system, superoxide dismutase (SOD) contents, reduced glutathione (GSH) contents, and malondialdehyde (MDA) contents were measured in colon and brain tissues. AECF significantly ameliorated the imbalance of the antioxidant systems. Also, AECF improved intestinal myeloperoxidase (MPO) activity, the abundance of the gut microbiome, short-chain fatty acids (SCFAs) contents, and tight junction protein expression against PM2.5-induced damage. In addition, AECF prevented PM2.5-induced inflammatory and apoptotic expression via the toll-like receptor-4 (TLR-4)/myeloid differentiation primary response 88 (MyD88) pathway in colon and brain tissues. Additionally, AECF enhanced the mitochondrial function, including the mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) contents in brain tissues. Furthermore, AECF regulated the cholinergic system, such as acetylcholine (ACh) contents, acetylcholinesterase (AChE) activity, and protein expression levels of AChE and choline acetyltransferase (ChAT) in brain tissues. To evaluate the effect of cognitive dysfunction caused by PM2.5-induced intestinal dysfunction, behavior tests such as Y-maze, passive avoidance, and Morris water maze tests were performed. From the results of the behavior tests, AECF ameliorated spatial learning and memory, short-term memory, and long-term learning and memory function. This study confirmed that AECF reduced PM2.5-induced cognitive dysfunction by regulating gut microbiome and inflammation, apoptosis, and mitochondrial function by enhancing the gut–brain axis. Based on these results, this study suggests that AECF, which contains fatty acid amides, might be a potential material for ameliorating PM2.5-induced cognitive dysfunction via gut–brain axis improvement.

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Piyasada Satılan Farklı Formlardaki Ganoderma lucidum Preparatlarında Antioksidan Kapasitenin Karşılaştırılması

Miser Salihoğlu,

Akkıran

2024

Değerlendirme süreci

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Ganoderma lucidum (Curtis) P. Karst. (Lingzhi veya Reyşi), Çin, Japonya ve diğer Asya ülkelerinde sağlığı ve uzun ömürlülüğü desteklemek için uzun bir kullanım geçmişine sahiptir. Kültür mantarları arasında, Reyşi, besin değerinden çok farmasötik değerinin önemli olması bakımından benzersizdir. Çay, diyet takviyeleri ve toz gibi çeşitli formlarda çeşitli ticari Reyşi ürünleri mevcuttur. Bunlar, meyve gövdesi, misel ve sporlar dahil olmak üzere mantarın farklı kısımlarından üretilmektedir. Reyşi'nin sağlık üzerinde yararları arasında kan glukoz seviyesininin kontrolü, bağışıklık sisteminin modülasyonu, hepatoproteksiyon, bakteriyostaz yer almaktadır. Mantarın farklı kısımlarından hazırlanan, basit tip, toz ve kapsül veya tablet şeklinde işlenen çok sayıda ürün şu anda piyasada bulunmaktadır ve ülkemizde de oldukça yaygın kullanılmaktadır. Çalışmamızda, Türkiye’de satılan farklı markalara ait Reyşi tabletlerinde ve toz formdaki çaylarında antioksidan aktivitenin karşılaştırılması ve incelenmesi DPPH, DMPD ve Folin Ciocalteu yöntemleri kullanılarak gerçekleştirilmiştir. Çalışmamızda elde ettiğimiz sonuçlara göre sulu mantar ekstrelerinden; N5, N1 ve N2 (259.8696 µg GAE/mL, 220.1594 µg GAE/mL, 185.6667 µg GAE/mL) yüksek, N3 ve N4 (80.01449 µg GAE/mL, 119.2899 µg GAE/mL) örneklerinin düşük fenolik içeriğe sahip olduğu görülmüştür. Antioksidan temizleme kapasitelerine bakıldığında ise örneklerin fenolik içerikleri ile yüzde temizleme kapasiteleri DMPD/EtOH, DMPD/su ve DPPH/EtOH paralel olarak bulunmuştur. IC50 değerleri DMPD sulu ekstreler için 0,155 mg/ml (N1), 1,704 mg/ml (N2), 7,453 mg/ml (N3), 6,570 mg/ml (N4), 2,223 mg/ml (N5); etanollü ekstreler için 0,138 mg/ml (N1),1,496 mg/ml (N2), 2,796 mg/ml (N3), 4,780 mg/ml (N4), 2,162 mg/ml (N5)’dir. DPPH sonuçlarının yüksek çıkması sebebiyle IC50 değerleri hesaplanamamıştır.

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Deniz Makroalgi Codium fragile (Suringar) Hariot ’in Kimyasal Bileşimi, In-Vitro Antimikrobiyal ve Antioksidan Aktivitelerinin Analizi

Cited by 3 publications

References 38 publications

Codium fragile Suppressed Chronic PM2.5-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice

Codium fragile Suppressed Chronic PM2.5-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice

Codium fragile Suppresses PM2.5-Induced Cognitive Dysfunction by Regulating Gut–Brain Axis via TLR-4/MyD88 Pathway

Piyasada Satılan Farklı Formlardaki Ganoderma lucidum Preparatlarında Antioksidan Kapasitenin Karşılaştırılması

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