Dental Care Professionals Should Avoid the Administration of Amoxicillin in Healthy Patients During Third Molar Surgery: Is Antibiotic Resistence the Only Problem?

Aragón-Martínez, Othoniel Hugo; Isiordia-Espinoza, Mario Alberto; Nava, Francisco J. Tejeda; Aranda‐Romo, Saray

doi:10.1016/j.joms.2016.04.026

Cited by 16 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unfortunately, during the past few decades, an increasing number of bacterial species have become resistant to AMX, making ABR one of the most critical health problems in the world . Lately, it was suggested that dental care professionals should avoid administering AMX to prevent ABR, especially in procedures in healthy patients during third molar surgery …”

Section: Antibiotic Prophylaxis Guidelines Recommended By Aha For Bacmentioning

confidence: 99%

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

Loyola-Rodríguez

Miranda

Loyola-Leyva

et al. 2019

Special Care in Dentistry

View full text Add to dashboard Cite

The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram‐negative and Gram‐positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.

show abstract

Section: Antibiotic Prophylaxis Guidelines Recommended By Aha For Bacmentioning

confidence: 99%

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

Loyola-Rodríguez

Miranda

Loyola-Leyva

et al. 2019

Special Care in Dentistry

View full text Add to dashboard Cite

show abstract

“…Qualitative evidence suggests that inappropriate prescribing of antibiotics is a common practice in dentistry . The unnecessary use of antibiotics promotes global health problems, such as dysbiosis and bacterial resistance to antibiotics . Ingestion of antibiotic produces gut dysbiosis (namely alteration of the function and diversity of bacteria in the intestinal microbiome) in patients .…”

mentioning

confidence: 99%

“…Ingestion of antibiotic produces gut dysbiosis (namely alteration of the function and diversity of bacteria in the intestinal microbiome) in patients . In addition, dysbiosis of the gut microbiome can be induced by other factors, such as type of diet and lifestyle habits . Approximately 30–400 trillion microorganisms inhabit the healthy intestinal tract in humans .…”

mentioning

confidence: 99%

“…Moreover, the gut microbiome induces the dendritic and follicular dendritic cells to produce immunoglobulin A‐secreting plasma cells, and in turn, immunoglobulin A regulates the composition and function of the intestinal microflora . Consequently, an imbalance of the gut microbiome can result in dysbiosis‐related diseases in patients, such as increased susceptibility to infectious diseases, altered immune homeostasis, allergic diseases, metabolic syndrome, obesity and others . Alterations in the gut microbiome caused by exposure to systemic antibiotics are usually reversed within 2 months .…”

mentioning

confidence: 99%

“…Diarrhoea, gastric pain and nausea are linked to dysbiosis . Antibiotic‐associated diarrhoea (AAD) may occur during antibiotic treatment but also after the antibiotic has been discontinued .…”

mentioning

confidence: 99%

See 2 more Smart Citations