Dental caries: Genetic and protein interactions

Cavallari, Tayla; Arima, Letícia Yumi; Ferrasa, Adriano; Moysés, Samuel Jorge; Moysés, Simone Tetü; Herai, Roberto Hirochi; Werneck, Renata Iani

doi:10.1016/j.archoralbio.2019.104522

Cited by 17 publications

(13 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to environmental factors, many reviews and systematic evaluations have shown that genetic polymorphisms are associated with dental caries susceptibility. 17 – 19 LTF is a gene encoding a multi-functional iron-binding glycoprotein in mammals. This protein is secreted mainly by eosinophilic neutrophils and is present in various biological body fluids (e.g., saliva, tears, and other fluids); thus, it is an important non-heme iron-binding protein in the human body.…”

Section: Discussionmentioning

confidence: 99%

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

Hu¹,

Zhou²,

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Objective With the development of human genomics, the genetic factors associated with dental caries have receiving increasing attention. This study was performed to evaluate the relationship between lactoferrin ( LTF) and mannose-binding lectin 2 ( MBL2) gene single nucleotide polymorphisms (SNPs) and dental caries susceptibility in Chinese children. Methods This prospective case–control study included 360 unrelated children (aged 12–15 years) who received oral health examinations and questionnaire surveys. The children were divided into two groups by counting the numbers of decayed, missing, and filled teeth (DMFT/dmft): case group (n = 162, DMFT/dmft ≥ 1) and control group (n = 198, DMFT/dmft = 0); non-invasive saliva samples were collected to extract genomic DNA. Six SNPs ( rs2073495C/G, rs1042073C/T, rs10865941C/T, and rs1126477A/G in LTF; rs7096206C/G and rs7095891G/A in MBL2) were tested by mass spectrometry. Results The study included 360 individuals with (85 boys and 77 girls) and without a history of caries (96 boys and 102 girls). There were no statistically significant differences in alleles and genotypes among the six SNPs between the two groups. Conclusion There is no evidence that polymorphisms of LTF and MBL2 genes are associated with dental caries susceptibility in populations from northwest China; further confirmation is needed with larger sample sizes.

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

Hu¹,

Zhou²,

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…In a review of genetic and protein interactions in dental caries, Cavallari et al (2019) provided an overview of 27 genes and genes—protein networks associated with protection or risk of dental caries. These were PRP1, PR, PA, MG1, MG2, AMELX, ENAM, TUFT1, KLK4, HLADR4, TAS1R3, TAS2R38, MBL2, MMP20, MMP2, MMP9, MMP13, GLUT2, TAS1R2, CA-VI, DEFB1, ALOX15, VDR-TAQI, MMP3, CA6, MUC5B, VDR-FOK and are related to enamel formation, development and mineralisation, host immune response and the composition of saliva ( 51 ).…”

Section: Dental Cariesmentioning

confidence: 99%

The genetic determinants of oral diseases in Africa: The gaps should be filled

Sudi

Kabbashi²,

Roomaney³

et al. 2022

Front. Oral. Health

View full text Add to dashboard Cite

Oral diseases are a major health concern and are among the most prevalent diseases globally. This problem is becoming more prominent in the rapidly growing populations of Africa. It is well documented that Africa exhibits the most diverse genetic make-up in the world. However, little work has been conducted to understand the genetic basis of oral diseases in Africans. Oral health is often neglected and receives low prioritisation from funders and governments. The genetic determinants of highly prevalent oral diseases such as dental caries and periodontal disease, and regionally prevalent conditions such as oral cancer and NOMA, are largely under-researched areas despite numerous articles alluding to a high burden of these diseases in African populations. Therefore, this review aims to shed light on the significant gaps in research on the genetic and genomic aspects of oral diseases in African populations and highlights the urgent need for evidence-based dentistry, in tandem with the development of the dentist/scientist workforce.

show abstract

“…Family oral health history is a valid representation of the existence of common genetic and environmental factors that may contribute to an individual's oral health condition. It is also related to how these influences could contribute to health across all generations (CAVALLARI et al, 2019). Very few studies, however, have been conducted into intergenerational associations of an oral health nature (SHEARER et al, 2012).…”

Section: Familymentioning

confidence: 99%

“…At the genetic level, 23 genes have at least one other gene with which they interact. The genes TUFT1, VDR, TFIP11, LTF, HLA-DRB1, MMP2, MMP3 and MUC5B were shown to be connected in interactive networks by at least 10 other genes (CAVALLARI et al, 2019). However, no descriptions of the genetic model involved have been performed in respect of populations containing extreme phenotype (high DMFT index -decayed, missing or filled permanent teeth).…”

Section: Introductionmentioning

confidence: 99%

“…In order to determine the presence of one or more major genes within families that might explain all or part of the family aggregation of the trait observed, the complex segregation analysis (CSA) may be used. The goal of CSA is to detect and discriminate between and amongst the different factors causing familial resemblance, ultimately aiming to demonstrate a major gene effect (OPAL et al, 2015) It should be emphasized that, despite advances in molecular genetics and genome-wide association studies, the exact nature of the genetic component that controls susceptibility to dental caries is still unclear (CAVALLARI et al, 2019). Understanding the genetic aspects involved in the pathogenesis of caries could give rise to preventive strategies for this disease, which is one of the most prevalent in the world (OPAL et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic Pattern of Dental Caries in Families from a City in Southern Brazil

et al. 2020

View full text Add to dashboard Cite

Fatores genéticos desempenham um importante papel na susceptibilidade à carie dentária na população. O objetivo deste estudo foi investigar, por meio da análise de segregação complexa (ASC), o padrão intergeracional da ocorrência da cárie dentária em famílias brasileiras. O estudo foi epidemiológico genético, observacional e transversal. A amostra foi constituída de 21 famílias que exibiam altos níveis de cárie (CPOD>4.5). Os participantes passaram por avaliação bucal, sendo que a cárie dentária foi registrada de acordo com o índice CPOD (dente cariado, perdido e obturado), seguindo as diretrizes da Organização Mundial de Saúde, bem como a presença de gengivite foi avaliada utilizando o índice de sangramento gengival. Foi aplicado um questionário para identificação dos fatores socioenconômicos e práticas de saúde bucal. Análises de regressão linear simples e múltipla foram realizadas para testar a associação entre cárie dentária e as variáveis independentes. A significância estatística foi considerada no nível de 5%, a ASC foi interpretada pelo programa S.A.G.E. A prevalência de cárie foi de 89,2%. Na análise múltipla, apenas a gengivite permaneceu associada (p = 0,005). A análise visual dos genogramas identificou um padrão familiar que sugere a predominância do modelo autossômico dominante. A frequência do alelo de resistência "A" foi estimada em 0,22. O valor médio de cárie foi de 1,35 para os genótipos AA e AB e de 3,95 para o BB. Os resultados do presente estudo fornecem evidências da presença de um gene importante com efeito dominante no controle do desenvolvimento de cárie dentária dentro da mesma família. Palavras-chave: Cárie Dentária. Epidemiologia Genética. Reabilitação Oral. Susceptibilidade. Abstract Genetic factors may play an important role in the susceptibility to dental caries of the human population. The objective of this study was to investigate, by means of complex segregation analysis (CSA), the intergeneration pattern in the occurrence of caries in Brazilian families. This was a cross-sectional, observational genetic epidemiological study. The sample consisted of 21 families whose probands exhibited high levels of caries (DMFT>4.5). All participants underwent an oral examination. Dental caries was recorded according to the DMFT index (decayed, missing, and filled teeth), according to World Health Organization guidelines and the presence of gingivitis was assessed by using the gingival bleeding index. A questionnaire was applied to identify the sociodemographic profile and practices on oral health. Simple and multiple linear regression analysis were performed to test the association between dental caries and the independent variables. Statistical significance was considered at the 5% level. The S.A.G.E program drove the CSA. The prevalence of caries was 89.2%. In the multiple analysis only gingivitis remained associated (p = 0.005). The visual analysis of genograms identified a family pattern that suggests the predominance of the autosomal dominant model. The frequency of resistance allele "A" was estimated at 0.22. The mean decay value was 1.35 for AA and AB genotypes and 3.95 for BB. The results of the present study provide evidence as to the presence of a major gene with a dominant effect controlling the appearance of dental caries, within the same family. Keywords: Dental Caries. Genetic Epidemiology. Oral Rehabilitation. Susceptibility.

show abstract

Dental caries: Genetic and protein interactions

Cited by 17 publications

References 71 publications

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

The genetic determinants of oral diseases in Africa: The gaps should be filled

Genetic Pattern of Dental Caries in Families from a City in Southern Brazil

Contact Info

Product

Resources

About