Dental implant modifications for medically compromised patients

Ngeow, Wei Cheong; Lim, Daniel V.; Tan, Chuey Chuan; Shetty, Neeta; Marla, Vinay

doi:10.1016/b978-0-12-819586-4.00014-7

Cited by 3 publications

(3 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone quality at both the donor and recipient sites dictates treatment outcome in human donor autograft procedures. However, bone quality is independent of bone mass, as observed in bone with pathological disorder [ 55 ]. Therefore, the alternative is to use allograft, xenograft or synthetic bone material [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Facts to Consider in Developing Materials That Emulate the Upper Jawbone: A Microarchitecture Study Showing Unique Characteristics at Four Different Sites

et al. 2023

View full text Add to dashboard Cite

The maxilla is generally acknowledged as being more trabecular than the mandible. Allograft currently available for use in the maxillofacial region is harvested from the hip and long bones, irrespective of their local characteristics, and grafted onto the jawbones. Other alternative are autograft or commercially available bone substitutes. Due to their inherent differences, an in-depth understanding of the bone microarchitecture is important to develop the most compatible graft for use at the maxilla. This cross-sectional study aimed to determine the microstructures of bone harvested from different sites of the maxilla, to be used for standard setting. Forty-nine specimens from seven human cadavers were harvested from the zygomatic buttress, anterior maxillary sinus wall, anterior nasal spine and anterior palate. Each bone block, measuring of 10 mm × 5 mm, was harvested using rotary instruments. Bone analysis was performed following micro-computed tomography to obtain trabecular number (Tb.N), trabecular separation (Tb.Sp), trabecular thickness (Tb.Th), and bone volume fraction (BV/TV). There were site-related differences, with BV/TV that ranged between 37.38% and 85.83%. The Tb.N was the lowest at the palate (1.12 (mm−1)) and highest at the anterior maxillary sinus wall (1.41 (mm−1)) region. The palate, however, had the highest trabecular separation value (Tb.Sp) at 0.47 mm. The TB.Th was the lowest at the anterior nasal spine (0.34 mm) but both the zygoma and anterior maxillary sinus regions shared the highest Tb.Th (0.44 mm). Except for having the lowest Th.Sp (0.35 mm), the anterior maxillary sinus wall consistently showed higher values together with the zygomatic buttress in all other parameters. Concurring with current clinical practice of harvesting autograft from the zygomatic buttress and anterior maxillary sinus wall, their bony characteristic serve as the microarchitecture standard to adopt when developing new bone graft materials for use in the maxilla.

show abstract

Section: Discussionmentioning

confidence: 99%

Facts to Consider in Developing Materials That Emulate the Upper Jawbone: A Microarchitecture Study Showing Unique Characteristics at Four Different Sites

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Moreover, upon the dissolution of the BAG phase, the Ti macroporous structure becomes available for bone tissue ingrowth enabling mechanical interlocking of the surface with the surrounding bone for an improved fixation. 2 It is well known that control over both the composition and mesopore characteristics of the BAG allows adjusting the stability period, 20 yet, the incorporation of the BAG phase in the macroporous Ti matrix reduces the water contact. Future studies should, therefore, focus on characterizing the dissolution behavior of the mesoporous BAG from the macroporous Ti and its influence on the controlled release profile to further proof the potential of antimicrobial-releasing Ti/BAG composite materials for orthopedic applications.…”

Section: Chx Is Released Through the Ti/bag Composite Materials In A Controlled Way And Inhibits S Mutans Biofilm Formationmentioning

confidence: 99%

“…), surface modifications that introduce more bioactive materials are envisaged. 2 Bioactive glasses (BAGs), typically based on the main components SiO 2 , CaO, and P 2 O 5 , are such materials having osteoinductive and angiogenic properties that can enhance bone formation through their dissolution when exposed to biological fluids. Moreover, the specific properties of BAGs can be influenced and possibly controlled to a greater extent by adjusting the BAG structure at the nanoscale, such as by developing nanoparticles or nanofibers or by introducing nanopores by means of sol-gel synthesis.…”

Section: Introductionmentioning

confidence: 99%

Development of mesoporous bioactive glass‐containing macroporous titanium for controlled release of antimicrobial drugs

et al. 2021

View full text Add to dashboard Cite

Biofilm-associated infections pose a serious threat to the long-term survival of metal-based bone implants, which can potentially be resolved by the controlled delivery of antimicrobial agents locally at the implant surface. Mesoporous bioactive glasses (BAGs) are multifunctional materials able to combine bone-bonding properties with such a drug release functionality. Here, we propose for the first time to modify a macroporous Ti implant material with an antimicrobial-releasing BAG phase. The feasibility of a sol-gel synthesis route, including the structure-directing agent (SDA) Pluronic F127, and its effect on the mesoporous structure and concomitant drug release performance was evaluated. Mesopore sizes ranged from 3.4 nm for SDA-free to 3.7 nm for SDA-derived BAG, thereby both enabling configurational diffusion of the antiseptic chlorhexidine (CHX), but the latter showed a more narrow pore size distribution leading to a slower, more controlled release. Adjusting the feed concentration allowed fine-tuning the daily CHX release through the SDA-derived Ti/BAG composite to 1.4 μM. Even though just below the biofilm inhibitory concentration, this daily release rate was sufficient to effectively prevent Streptococcus mutans biofilm formation on the surface of the material. This proof-of-concept for a temporary antimicrobial-releasing bioceramic surface modification on Ti can be of interest for orthopedic implants.

show abstract

Titanium Dental Implants in Compromised Conditions: Need for Enhanced Bioactivity and Therapy

Kocak-Oztug

Ravali

2023

Surface Modification of Titanium Dental Implants

View full text Add to dashboard Cite

Dental implant modifications for medically compromised patients

Cited by 3 publications

References 136 publications

Facts to Consider in Developing Materials That Emulate the Upper Jawbone: A Microarchitecture Study Showing Unique Characteristics at Four Different Sites

Facts to Consider in Developing Materials That Emulate the Upper Jawbone: A Microarchitecture Study Showing Unique Characteristics at Four Different Sites

Development of mesoporous bioactive glass‐containing macroporous titanium for controlled release of antimicrobial drugs

Titanium Dental Implants in Compromised Conditions: Need for Enhanced Bioactivity and Therapy

Contact Info

Product

Resources

About