Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair

Sultan, Nessma; Amin, Laila E; Zaher, Ahmed Ragheb; Scheven, Ben A.; Grawish, Mohammed E.

doi:10.5321/wjs.v7.i1.1

Cited by 18 publications

(52 citation statements)

References 141 publications

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“…Studies show that DPSCs can successfully differentiate into glial cells and neural cells. They are capable of secreting various neurotropic factors; thus, they are suitable for peripheral nerve repair (Sultan, Amin, Zaher, Scheven, & Grawish, ).…”

Section: Transplantation Of Cell‐seeded Nerve Conduits For Peripheralmentioning

confidence: 99%

The advances in nerve tissue engineering: From fabrication of nerve conduit toin vivonerve regeneration assays

Jahromi

Razavi

Bakhtiari

2019

J Tissue Eng Regen Med

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Peripheral nerve damage is a common clinical complication of traumatic injury occurring after accident, tumorous outgrowth, or surgical side effects. Although the new methods and biomaterials have been improved recently, regeneration of peripheral nerve gaps is still a challenge. These injuries affect the quality of life of the patients negatively. In the recent years, many efforts have been made to develop innovative nerve tissue engineering approaches aiming to improve peripheral nerve treatment following nerve injuries. Herein, we will not only outline what we know about the peripheral nerve regeneration but also offer our insight regarding the types of nerve conduits, their fabrication process, and factors associated with conduits as well as types of animal and nerve models for evaluating conduit function. Finally, nerve regeneration in a rat sciatic nerve injury model by nerve conduits has been considered, and the main aspects that may affect the preclinical outcome have been discussed.

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Section: Transplantation Of Cell‐seeded Nerve Conduits For Peripheralmentioning

confidence: 99%

The advances in nerve tissue engineering: From fabrication of nerve conduit toin vivonerve regeneration assays

Jahromi

Razavi

Bakhtiari

2019

J Tissue Eng Regen Med

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“…Clinical data continue to show successful applications of MSCs, and the completed trials have been listed at (accessed on 1 November 2021), the database of The National Institutes of Health [ 8 , 10 ]. Reports also show that MSCs obtained from different sources are effective in tissue regeneration, but there are still certain important obstacles that limit their application in regenerative medicine [ 8 , 11 , 12 ]. Most clinical trials use a similar procedure to prepare MSCs for therapy.…”

Section: Introductionmentioning

confidence: 99%

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Bär

Lis-Nawara

Grelewski

2021

IJMS

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The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not been implemented in human medicine because the paracrine effect of the bioactive factors secreted by human dental pulp stem cells (hDPSCs) and human exfoliated deciduous teeth (SHEDs) is not completely understood. In this review, we outline the current data on the hDPSC- and SHED-derived secretome as a potential candidate in the regeneration of bone, cartilage, and nerve tissue. Published reports demonstrate that the dental MSC-derived secretome/conditional medium may be effective in treating neurodegenerative diseases, neural injuries, cartilage defects, and repairing bone by regulating neuroprotective, anti-inflammatory, antiapoptotic, and angiogenic processes through secretome paracrine mechanisms. Dental MSC-secretomes, similarly to the bone marrow MSC-secretome activate molecular and cellular mechanisms, which determine the effectiveness of cell-free therapy. Many reports emphasize that dental MSC-derived secretomes have potential application in tissue-regenerating therapy due to their multidirectional paracrine effect observed in the therapy of many different injured tissues.

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“…1,15 Adult stem cells are multipotent cells capable of differentiation in multiple lineages, such as osteocytes, chondrocytes, adipocytes, and neuron-like cells, respectively. 15,16 In addition, stem cell-based tissue regeneration offers several advantages, including the avoidance of complex surgeries, low risk of contamination, high quality of tissue regeneration, and low rate of autoimmune rejection. 16 The molar tooth is one of the rich sources of dental stem cells (DSCs).…”

Section: Introductionmentioning

confidence: 99%

“…15,16 In addition, stem cell-based tissue regeneration offers several advantages, including the avoidance of complex surgeries, low risk of contamination, high quality of tissue regeneration, and low rate of autoimmune rejection. 16 The molar tooth is one of the rich sources of dental stem cells (DSCs). DSCs can be isolated from different parts of dental tissues, such as the dental pulp region (DPSCs), exfoliated primary teeth (SHED), periodontal ligaments (PDLSCs), or form apical papilla (SCAPs).…”

Section: Introductionmentioning

confidence: 99%

“…DSCs can be isolated from different parts of dental tissues, such as the dental pulp region (DPSCs), exfoliated primary teeth (SHED), periodontal ligaments (PDLSCs), or form apical papilla (SCAPs). 16,17 The human periodontal ligament stem cells (hPDLSCs) are a promising model for dental tissue engineering and regenerative medicine. One of our previous studies showed that stem cells from apical papilla (SCAPs) could differentiate into odontogenic, osteogenic, chondrogenic, and adipogenic lineages.…”

Section: Introductionmentioning

confidence: 99%

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Electromagnetic field-assisted cell-laden 3D printed poloxamer-407 hydrogel for enhanced osteogenesis

et al. 2021

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Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair

Cited by 18 publications

References 141 publications

The advances in nerve tissue engineering: From fabrication of nerve conduit toin vivonerve regeneration assays

The advances in nerve tissue engineering: From fabrication of nerve conduit toin vivonerve regeneration assays

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Electromagnetic field-assisted cell-laden 3D printed poloxamer-407 hydrogel for enhanced osteogenesis

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