INTRODUCTION. Treatment with braces can correct pathologies of the bite, temporomandibular joint, and improve the facial and smile aesthetics. However, along with the positive effects of braces, there are a number of negative effects, one of which is the formation of denticles caused by mechanical stress during orthodontic treatment. Understanding not only the advantages, but also the disadvantages of braces systems can minimize the negative effects of treatment with non-removable orthodontic appliances by means of modern technologies.AIM. Establishing the effects of mechanical forces applied to the tooth during orthodontic treatment with braces on the formation and growth of denticles.MATERIALS AND METHODS. 41 cone-beam computed tomograms (CBCTs) of patients aged 11 to 59 years, randomly selected, treated with non-removable orthodontic appliances for two years were studied. A total of 90 teeth were found in which pulp denticles formed primarily or grew in size. CBCT was analyzed in Planmeca Romexis Review software before and 2 years after orthodontic treatment. Findings were recognized as statistically significant at p < 0.05.RESULTS. The formation and development of denticles after wearing orthodontic appliances was observed in 87.2 % (n = 30) of cases). Primary denticle formation occurred in 46.2 % (n = 18) of cases, and an increase in denticle size was observed in 25.6 % (n = 10) of cases.CONCLUSIONS. The obtained statistical data supports the relationship between the effects of mechanical stress on teeth during orthodontic treatment and denticle formation.