Dentine–Pulp Complex Regeneration

Peters, Ove A.; Gaudin, Alexis

doi:10.1007/978-3-030-59809-9_3

Cited by 6 publications

(9 citation statements)

References 140 publications

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“…A decellularized matrix attracts stem cells and progenitors. Regeneration in those investigations parallels natural cell recruitment from neighboring tissues to the new ECM network (Peters et al 2021).…”

Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 93%

“…The model, cell exclusion approaches, stem cell potentials, micro-environment, teeth, in situ microcirculation, surgical process, and biomaterials are all factors that affect study outcomes. inflammation may also hinder neo-angiogenesis and mineralized tissue development, which contribute to regeneration defects (Peters et al 2021).…”

Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 99%

“…It must also be bioactive and dynamic, regulating cellular activity and intercellular communication (Gong et al 2016). Electrospinning, gas foaming, melt molding, freeze-drying, solvent casting, particle leaching, and phase separation are traditional scaffolding processes that cannot be accurately controlled (Peters et al 2021).…”

Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 99%

“…It may be employed for high throughput manufacture and provides fine control over scaffolds' exterior and interior morphology. Because of its porous interior, the 3D-printed scaffold can allow nutrients and oxygen to reach the cells inside it, promoting healthy cellular metabolism (Peters et al 2021).…”

Section: D Printed Scaffold Challenges Dental Regenerationmentioning

confidence: 99%

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Challenges in optimizing 3D scaffold for dentin-pulp complex regeneration

ZAHEDAH,

DİNÇ

2023

Bulletin of Biotechnology

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Regenerating dentin-pulp complex (DPC) using tissue engineering offers a novel and promising therapeutic alternative for restoring teeth. A crucial component of such a therapy is the designing and fabrication of an appropriate 3D Scaffold. In this review, we set out to highlight some of the general challenges associated with optimizing the most suitable scaffold for DPC regeneration to develop "bio-mimetic" approaches that influence stem cell proliferation, differentiation, and angiogenesis. It is essential to comprehend the biology and physical features of the dentin-pulp complex with updated bionanotechnology to overcome the limitations of biomaterials to address the challenges in manufacturing the optimal scaffold. To date, current scaffolding models fail to regenerate a whole tooth. The success of regenerative dentistry relies on stem cells and scaffolds may shape the future of dental treatment.

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Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 93%

Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 99%

Section: Scaffolds To Regenerate Dentin-pulp Complexmentioning

confidence: 99%

Section: D Printed Scaffold Challenges Dental Regenerationmentioning

confidence: 99%

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Challenges in optimizing 3D scaffold for dentin-pulp complex regeneration

ZAHEDAH,

DİNÇ

2023

Bulletin of Biotechnology

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“…Accidental root perforation during root canal treatment, vital pulp therapy and management of immature teeth with necrotic pulps require advanced interventions to decrease inflammatory responses and promote tissue regeneration (Peters et al, 2021). Therefore, ideal endodontic materials not only should be safe to apply but also need to be bioactive.…”

Section: Biocompatibility Testing: Considerations and Aspectsmentioning

confidence: 99%

A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials

2022

Self Cite

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Materials used for endodontics and with direct contact to tissues have a wide range of indications, from vital pulpal treatments to root filling materials and those used in endodontic surgery. In principle, interaction with dental materials may result in damage to tissues locally or systemically. Thus, a great variety of test methods are applied to evaluate a materials' potential risk of adverse biological effects to ensure their biocompatibility before commercialization. However, the results of biocompatibility evaluations are dependent on not only the tested materials but also the test methods due to the diversity of these effects and numerous variables involved. In addition, diverse biological effects require equally diverse assessments on a structured and planned approach. Such a structured assessment of the materials consists of four phases: general toxicity, local tissue irritation, pre‐clinical tests and clinical evaluations. Various types of screening assays are available; it is imperative to understand their advantages and limitations to recognize their appropriateness and for an accurate interpretation of their results. Recent scientific advances are rapidly introducing new materials to endodontics including nanomaterials, gene therapy and tissue engineering biomaterials. These new modalities open a new era to restore and regenerate dental tissues; however, all these new technologies can also present new hazards to patients. Before any clinical usage, new materials must be proven to be safe and not hazardous to health. Certain international standards exist for safety evaluation of dental materials (ISO 10993 series, ISO 7405 and ISO 14155‐1), but researchers often fail to follow these standards due to lack of access to standards, limitation of the guidelines and complexity of new experimental methods, which may cause technical errors. Moreover, many laboratories have developed their testing strategy for biocompatibility, which makes any comparison between findings more difficult. The purpose of this review was to discuss the concept of biocompatibility, structured test programmes and international standards for testing the biocompatibility of endodontic material biocompatibility. The text will further detail current test methods for evaluating the biocompatibility of endodontic materials, and their advantages and limitations.

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