Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Bajunaid, Salwa Omar; Baras, Bashayer H.; Weir, Michael D.; Xu, Hockin H.K.

doi:10.3390/polym14020230

Cited by 24 publications

(21 citation statements)

References 52 publications

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Section: Resultsmentioning

confidence: 99%

“…This dual incorporation of MPC and DMAHDM reduced Candida albicans biofilm colony-forming unit by two orders of magnitude. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups (Figure 3) [35]. Polymers 2022, 14, x FOR PEER REVIEW 5 of 12 addition of ZrO2NPs significantly reduced the adhesion of the biofilm to repaired and cold-cured acrylic resin and had a significant antifungal effect [33].…”

Section: Biocidal Surface Coating (Protein Repellent Agent)mentioning

confidence: 98%

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How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review

Bajunaid

2022

Polymers

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Denture stomatitis is a common oral infection caused by Candid albicans. It occurs under removable dentures due to several causative and contributing factors. If not treated, it can lead to fatal systemic candida infections. Different materials and techniques have been used to treat denture stomatitis; however, no single treatment has succeeded. The purpose of this study was to review novel techniques for incorporating antimicrobial and protein repellent agents into denture acrylic resin materials and their effect on the adhesion of Candida albicans to denture base acrylic resin materials to prevent and/or treat denture stomatitis. A systematic review was conducted in which an electronic search was undertaken using different databases and relevant keywords. The literature search revealed numerous studies describing different antifungal materials incorporated into different denture acrylic resin materials. The investigated materials showed significant antimicrobial activity with slight or no effect on the physical and mechanical properties; however, the optical properties were particularly affected with higher concentrations. The incorporation of antimicrobial agents to reduce or prevent Candida albicans biofilm formation on acrylic resin proved to be very effective, and this effect was found to be proportional to the percentage of the material used. The latter should be considered carefully not to alter the physical, mechanical or optical characteristics of the denture base material.

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Section: Resultsmentioning

confidence: 99%

Section: Biocidal Surface Coating (Protein Repellent Agent)mentioning

confidence: 98%

How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review

Bajunaid

2022

Polymers

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“…One of the existing strategies to modify acrylic materials and form bioactive materials is the addition of various types of nanomaterials such as silver and titanium oxide 7 – 10 . Another strategy is the addition of various types of medicinal substances, such as antibiotics 11 and chlorhexidine 12 , 13 . In addition to these approaches, the use of different types of bioactive glasses can also enable the modification of acrylic materials.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of acrylic resins with bioactive glasses

Raszewski¹,

Chojnacka

Mikulewicz

2022

Sci Rep

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This study aimed to prepare a bioactive acrylic material by adding different types of glasses. Commercially available polymerized acrylic resin was mixed with 10% of four different types of glasses in the powder form and cured. Flexural strength, sorption, and solubility of the samples were tested according to ISO 20795-1:2013. The total number of samples used in the tests were 60. The materials were placed in artificial saliva of pH 4 and 7, and elution was performed for 0, 1, 28, and 42 days. The collected samples were analyzed using inductively coupled plasma atomic emission spectrometry to detect Ca, P, and Si ions and using ion chromatography to detect F ions. The materials obtained after modification with glasses showed lower compressive strength compared with pure polymethyl methacrylate but met the standard requirements. Two glass types showed higher solubility values compared with the value defined by the ISO standard. Biomin C and S53P4 released Ca, P, and Si ions, respectively, after 42 days in artificial saliva. Acrylic resins modified with 10% Biomin C and S53P4 glasses can be a valuable source of Ca and P ions under acid conditions for 28 and 42 days.

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“…The last phase is dispersion: the release of more virulent Candida cells from the biofilm into the surrounding environment. It has been noted that for patients who use removable prosthetic restorations, it is necessary to repair or replace a restoration made of acrylic after C. albicans infection [ 23 , 24 , 25 , 26 ]. The question is still unclear whether similar procedures should be performed for composite fillings and filled root canals.…”

Section: Discussionmentioning

confidence: 99%

Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings

et al. 2022

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Recurrent oral infections, as manifested by endodontic and periodontal disease, are often caused by Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans). Here, we assessed the anti-biofilm activity of ceragenin CSA-44 against these microbes growing as a biofilm in the presence of saliva on the surface of human teeth and dental composite (composite filling) subjected to mechanical stresses. Methods: Biofilm mass analysis was performed using crystal violet (CV) staining. The morphology, viscoelastic properties of the biofilm after CSA-44 treatment, and changes in the surface of the composite in response to biofilm presence were determined by AFM microscopy. Results: CSA-44 prevented biofilm formation and reduced the mass of biofilm formed by tested microorganisms on teeth and dental composite. Conclusion: The ability of CSA-44 to prevent the formation and to reduce the presence of established biofilm on tooth and composite filling suggests that it can serve as an agent in the development of new methods of combating oral pathogens and reduce the severity of oral infections.

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Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Cited by 24 publications

References 52 publications

How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review

How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review

Preparation and characterization of acrylic resins with bioactive glasses

Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings

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