2011
DOI: 10.1007/s10495-011-0633-x
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Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells

Abstract: The continuous exposure of the colonic epithelium to high concentrations of bile acids may exert cytotoxic effects and has been related to pathogenesis of colon cancer. A better knowledge of the mechanisms by which bile acids induce toxicity is still required and may be useful for the development of new therapeutic strategies. We have studied the effect of deoxycholic acid (DCA) and chenodeoxycholic acid (CDCA) treatments in BCS-TC2 human colon adenocarcinoma cells. Both bile acids promote cell death, being th… Show more

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Cited by 109 publications
(80 citation statements)
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“…4), evidencing that apoptosis is a major cell death pathway induced by DCA. In fact, DCA also increased caspase-8-and -9-like activities, up until 52 h of incubation (P Ͻ 0.05) (data not shown), implying the engagement of both the death receptor and the mitochondrial pathways of apoptosis (39). End-stage apoptosis, evaluated using Hoechst staining, confirmed DCA-induced nuclear fragmentation in ϳ30% of cultured hepatocytes throughout the time course (P Ͻ 0.01) (Fig.…”
Section: Resultsmentioning
confidence: 75%
“…4), evidencing that apoptosis is a major cell death pathway induced by DCA. In fact, DCA also increased caspase-8-and -9-like activities, up until 52 h of incubation (P Ͻ 0.05) (data not shown), implying the engagement of both the death receptor and the mitochondrial pathways of apoptosis (39). End-stage apoptosis, evaluated using Hoechst staining, confirmed DCA-induced nuclear fragmentation in ϳ30% of cultured hepatocytes throughout the time course (P Ͻ 0.01) (Fig.…”
Section: Resultsmentioning
confidence: 75%
“…Primary bile acids have been demonstrated to protect against obesity and insulin resistance (33,36), whereas secondary bile acids are considered potentially toxic and associated with the development of certain cancers (4,21,37). However, it remains unclear whether the balance of primary vs. secondary bile acids is responsible for gastric bypass-mediated metabolic benefits.…”
Section: Bd Results In Improved Adiposity and Glucose Tolerancementioning
confidence: 99%
“…While most bile acids aid solubilization of lipids and facilitate nutrient absorption, some are transformed by intestinal bacteria into toxic secondary bile acids in the colon [40]. Thus, the transformation of secondary bile acids in the colon could have cytotoxic effects that may contribute to various gastrointestinal diseases including colorectal cancer [41]–[43]. Therefore, it is possible that Fusobacterium is a commensal that gains from the disruption of intestinal homeostasis as a result of the presence of adenoma or cancer.…”
Section: Discussionmentioning
confidence: 99%