Deoxypodophyllotoxin Reduces Skin Pigmentation of Brown Guinea Pigs

Abstract

In this report, we have demonstrated that deoxypodophyllotoxin from Anthriscus sylvestris (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.

Bioactive Depsides and Anthocyanins from Jaboticaba (Myrciaria cauliflora)

“…The UV spectrum exhibited a peak at 267 nm with a shoulder at 298 nm, typical of a phenolic acid ester. The 1 H and 13 C NMR experiments were similar to literature values for 2 , with an additional methoxy signal at δ 3.57 (3H, s, OCH 3 -8) and 50.9 (OCH 3 -8) . The position of the methoxy group was established through HMBC correlations between the proton signal at δ 3.57 (OCH 3 -8) and δ 172.9 (C-8).…”

“…Depsides are phenolic compounds composed of two or more monocyclic aromatic units linked by an ester bond. They are most often found in lichens, but have also been isolated from higher plants, including species of the Ericaceae, Lamiaceae, and Papaveraceae. , They have not been previously reported in the Myrtaceae. Depsides have antibiotic, anti-HIV, and antiproliferative activity. , As inhibitors of prostaglandin biosynthesis and leukotriene B 4 biosynthesis, depsides are potent nonsteroidal anti-inflammatories …”

“…Compounds 2 − 4 , pyranocyanin B, protocatechuic acid, methyl protocatechuate, ellagic acid, quercimeritrin, and quercitrin were isolated and identified by comparison of spectroscopic measurements to published literature values. , Quercetin, isoquercitrin, rutin, myricitrin, cinnamic acid, O -coumaric acid, and gallic acid were identified by comparison of retention time, UV, and MS data to authentic standards.…”

Anthriscus sylvestris—Noxious Weed or Sustainable Source of Bioactive Lignans?

“…DPT shows potential as an efficient novel drug for treating hyperpigmentation caused via UV irradiation or by pigmented skin disorders [ 109 ]. Despite numerous pharmacological and cosmetic agents documented as melanogenesis inhibitors, only a limited number of these agents, due to toxicity or side effects, could be considered for the treatment of hyperpigmentation induced via UV irradiation or medical conditions like melasma [ 109 , 110 ].…”

“…DPT shows potential as an efficient novel drug for treating hyperpigmentation caused via UV irradiation or by pigmented skin disorders [ 109 ]. Despite numerous pharmacological and cosmetic agents documented as melanogenesis inhibitors, only a limited number of these agents, due to toxicity or side effects, could be considered for the treatment of hyperpigmentation induced via UV irradiation or medical conditions like melasma [ 109 , 110 ]. Experiment on guinea pigs showed that 0.05% DPT, topically applied, removed UV-caused pigmentation after 14 days of treatment, while 2% hydroquinone (the most popular depigmenting drug, in clinical use since 1961) [ 110 ], reduced pigmentation only after 21 days of treatment.…”