Depressed baroreflex sensitivity in patients with Alzheimer’s and Parkinson’s disease

Szili-Török, Tamás; Kálmán, János; Paprika, Dóra; Dibó, Gábor; Rózsa, Zs.; Rudas, László

doi:10.1016/s0197-4580(01)00210-x

Cited by 70 publications

(56 citation statements)

References 14 publications

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“…There are several previous reports indicating depressed baroreflex sensitivity in patients with Alzheimer's disease [7,25]. Moreover, impaired cognitive function has been reported in populations that typically demonstrate abnormal cardiovagal BRS, such as patients with hypertension [26,27] and orthostatic hypotension [28,29].…”

Section: Discussionmentioning

confidence: 98%

Association between cardiovagal baroreflex sensitivity and baseline cerebral perfusion of the hippocampus

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Association between cardiovagal baroreflex sensitivity and baseline cerebral perfusion of the hippocampus

et al. 2015

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“…23 Disturbed sympathetic nerve traffic [24][25][26] and depressed arterial BRS 27 underlie the increased cardiovascular mortality reported in association with the condition. 28 Stimulation of the STN improves the skeletal motor dysfunction in these patients 29 and alters cardiovascular parameters.…”

Section: Msna and Brs In Stn Targetsmentioning

confidence: 99%

Differentiated Baroreflex Modulation of Sympathetic Nerve Activity During Deep Brain Stimulation in Humans

et al. 2014

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Targeted electric deep brain stimulation in midbrain nuclei in humans alters cardiovascular parameters, presumably by modulating autonomic and baroreflex function. Baroreflex modulation of sympathetic outflow is crucial for cardiovascular regulation and is hypothesized to occur at 2 distinct brain locations. The aim of this study was to evaluate sympathetic outflow in humans with deep brain stimulating electrodes during ON and OFF stimulation of specific midbrain nuclei known to regulate cardiovascular function. Multiunit muscle sympathetic nerve activity was recorded in 17 patients undergoing deep brain stimulation for treatment of chronic neuropathic pain (n=7) and Parkinson disease (n=10). Sympathetic outflow was recorded during ON and OFF stimulation. Arterial blood pressure, heart rate, and respiratory frequency were monitored during the recording session, and spontaneous vasomotor and cardiac baroreflex sensitivity were assessed. Head-up tilt testing was performed separately in the patients with Parkinson disease postoperatively. Stimulation of the dorsal most part of the subthalamic nucleus and ventrolateral periaqueductal gray resulted in improved vasomotor baroreflex sensitivity, decreased burst frequency and blood pressure, unchanged burst amplitude distribution, and a reduced fall in blood pressure after tilt. Stimulation of the dorsolateral periaqueductal gray resulted in a shift in burst amplitude distribution toward larger amplitudes, decreased spontaneous beat-to-beat blood pressure variability, and unchanged burst frequency, baroreflex sensitivity, and blood pressure. Our results indicate that a differentiated regulation of sympathetic outflow occurs in the subthalamic nucleus and periaqueductal gray. These results may have implications in our understanding of abnormal sympathetic discharge in cardiovascular disease and provide an opportunity for therapeutic targeting.

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“…Several central nervous structures primarily affected in Alzheimer's disease are also implicated in the function of autonomic nervous system, such as cerebral neocortex, hypothalamus, locus coeruleus, limbic system formations, insular cortex and lower brain stem [6,9,22,25,29,30,32]. Thus, a link between higher cerebral and autonomic neural functions is a logical reasoning [10,16,29].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we showed subtle absolute and relative parasympathetic depression and relative sympathetic overactivity in Alzheimer's disease subjects with mild to severe cognitive deficit [35]. Markedly depressed baroreflex sensitivity reflecting abnormal autonomic regulation and association between neuropsychiatric deficits and altered heart rate responses to standing up were also observed [32]. In one study, the cardiac autonomic function assessed by short-term heart interval variability was shown to be unaltered [4].…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic modulation and cognitive status in Alzheimer’s disease

Toledo

Junqueira

2009

Clin Auton Res

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Depressed baroreflex sensitivity in patients with Alzheimer’s and Parkinson’s disease

Cited by 70 publications

References 14 publications

Association between cardiovagal baroreflex sensitivity and baseline cerebral perfusion of the hippocampus

Association between cardiovagal baroreflex sensitivity and baseline cerebral perfusion of the hippocampus

Differentiated Baroreflex Modulation of Sympathetic Nerve Activity During Deep Brain Stimulation in Humans

Cardiac autonomic modulation and cognitive status in Alzheimer’s disease

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