Depression After First Hospital Admission for Acute Coronary Syndrome: A Study of Time of Onset and Impact on Survival

Osler, Merete; Mårtensson, Solvej; Wium‐Andersen, Ida Kim; Prescott, Eva; Andersen, Per Kragh; Jørgensen, Terese Sara Høj; Carlsen, Kathrine; Wium‐Andersen, Marie Kim; Jørgensen, Martin Balslev

doi:10.1093/aje/kwv227

Cited by 37 publications

(24 citation statements)

References 28 publications

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“…Considering other clinical variables (i.e. baseline and cumulative scores at depression and anxiety) only age and incident depression were risk factors for the development of MACE, agreeing with the suggestion that incident depression (Keegan, Conroy, & Doyle, 2016;May et al, 2017) has a cardio-toxic effect, particularly in the year following an ACS (Osler et al, 2016). We found no dose-response relationship (Brunner et al, 2014).…”

Section: Discussionsupporting

confidence: 88%

Anxiety, depression, and cardiac outcomes after a first diagnosis of acute coronary syndrome.

Ossola¹,

Gerra²,

Panfilis³

et al. 2018

Health Psychology

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Objective. Depression is an established risk factor for Acute Coronary Syndrome (ACS) with an impact on cardiac prognosis, nonetheless the literature disagrees on the role played by anxiety. No study evaluated this relationship in a cardiac population with no history of depression and after their first ACS. The aim of this study is to explore these associations without the confounding role of long-lasting heart disease or psychiatric illnesses. Methods. Two-hundred-sixty-six patients with no history of depression completed the Hospital Anxiety and Depression Scale and the PRIME-MD at baseline and at 1, 2, 4, 6, 9, 12 and 24 months follow-up after their first ACS. During the follow-up period, we collected information regarding the major adverse cardiac events. Results. Developing a first-ever depressive episode, in a proportional hazard model, was associated with almost three times the risk of a recurrent cardiac event (OR=2.590; 95%CI=1.321, 5.078; p=.006). Furthermore, a moderation analysis revealed that increasing levels of baseline anxiety had opposing effects on cardiac outcomes, being protective only in those who did not develop incident depression (B=-0.0824; 95%CI=-0.164,-0.005; p=.048). No dose-response effect between depressive or anxious symptoms and cardiac outcomes emerged. Conclusion. Our results confirm the detrimental effect of depression on cardiac prognosis in a selected population and suggest that anxiety after the first ACS might have different roles depending on the illness' course.

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Section: Discussionsupporting

confidence: 88%

Anxiety, depression, and cardiac outcomes after a first diagnosis of acute coronary syndrome.

Ossola¹,

Gerra²,

Panfilis³

et al. 2018

Health Psychology

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“…Penelitian yang dilakukan Osler, dkk. 5 di Denmark, melihat onset dari depresi dalam 30 hari, satu tahun, dan dua tahun pada 97.793 pasien SKA. Didapatkan data bahwa depresi yang terjadi dalam 30 hari pertama sebanyak 724 pasien, lebih sedikit bila dibandingkan dengan depresi yang terjadi dalam satu tahun sebanyak 4.466 pasien.…”

Section: Diskusiunclassified

Hubungan Antara Depresi dan Ansietas Dengan Major Adverse Cardiac Event (MACE) Dalam 7 Hari Pada Pasien Sindrom Koroner Akut di RSCM

Sari¹,

Mudjaddid²,

Ginanjar³

et al. 2019

JPDI

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ABSTRAKPendahuluan. Salah satu penyebab kematian pada sindrom koroner akut adalah terjadinya komplikasi major adverse cardiac events (MACE). Terdapat beberapa prediktor terjadinya MACE pada pasien SKA, diantaranya depresi dan ansietas. Penelitian ini dilakukan untuk mengetahui hubungan antara depresi dan ansietas dengan major adverse cardiac event (MACE) dalam 7 hari pada pasien SKA.Metode. Penelitian dengan desain kohort prospektif untuk meneliti hubungan antara depresi dan ansietas dengan MACE dalam 7 hari pasien SKA, dengan menggunakan kuisioner HADS pada pasien SKA yang menjalani perawatan di ICCU, Rawat inap Gedung A RSCM pada bulan Januari -Mei 2018. Analisis bivariat dilakukan untuk menghitung risk ratio (RR) terjadinya MACE dalam 7 hari pada kelompok depresi dan ansietas dengan menggunakan SPSS.Hasil. Didapatkan jumlah subjek yang memenuhi kriteria inklusi sebanyak 114 orang. depresi didapatkan pada 7% subjek, ansietas didapatkan pada 28,95 % subjek, dan MACE didapatkan pada 9,6% subjek. Pada kelompok depesi, MACE 7 hari terjadi pada 12,5% subjek. Pada kelompok ansietas, MACE 7 hari terjadi pada 21,2 % subjek. Pada analisis bivariat didapatkan ansietas meningkatkan risiko terjadinya MACE dalam 7 hari pada pasien SKA, dengan risiko relatif (RR) sebesar 4,2 (IK 1,34 -13,70).Simpulan. Ansietas pada pasien SKA merupakan prediktor independen terjadinya MACE dalam 7 hari dan meningkatkan risiko terjadinya MACE 7 hari. Tidak didapatkan hubungan antara depresi dengan MACE dalam tujuh hari pada pasien SKA.Kata Kunci: depresi, ansietas, sindrom koroner akut, major adverse cardiac Event ABSTRACT Introduction. One of the causes of death in acute coronary syndrome is the occurrence of complication known as major adverse cardiac events (MACE). There are several predictors of the occurance of MACE in patients with ACS, including depression and anxiety. Thi study aimed to determine the association between depression and anxiety with major adverse cardiac events within 7 days in patients with acute coronary syndrome. Methods. Study with prospective cohort design to examine the association between depression and anxiety with MACE within 7 days of ACS patients, using HADS questionnaires on ACS patients undergoing treatment at ICCU, HospitalizationRSCM in January -May 2018. Bivariate analysis was performed to calculate the risk ratio (RR) of MACE occurrence within 7 days in the depression and anxiety group using SPSS.Results. Obtained number of subjects who meet the inclusion criteria of 114 people. Depression was obtained in 7% of subjects, Anxiety was obtained in 28,95% of subjects, and MACE was obtained in 9.6% of subjects. In the Depression group, MACE 7 days occurred in 12.5% of subjects. In the Anxiety group, MACE 7 days occurred in 21,2% of subjects. In bivariate analysis, Anxiety increased the risk of MACE within 7 days in patients with ACS, with relative risk (RR) of 4,2 (IK 1,70).Conclusions. Anxiety in patients with ACS is an independent predictor of MACE within 7 days and increases the risk of a 7 day MACE. There...

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“…Moreover, 1 in 10 patients with ACS develop depressive symptoms within the following year (Thombs et al, 2006). Depression itself seems to have a negative impact on cardiac prognosis (Lichtman et al, 2014), but the role played by anxiety (de Jager et al, 2018;Ossola et al, 2018), severity of depressive symptoms, and recurrence of the episodes (Osler et al, 2016;Yammine et al, 2017;Zuidersma et al, 2011) is still object for debate.…”

mentioning

confidence: 99%

Temperament and Depression After a First Acute Coronary Syndrome

et al. 2019

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Few studies assess the role of personality styles in predicting the onset of depression among cardiac patients. This study evaluates whether temperament and character can represent a risk factor for the development of incident first-ever depressive episodes in patients at their first acute coronary syndrome (ACS). Two hundred sixty-seven (72.1%) subjects (male) completed the Temperament and Character Inventory (TCI) a few days after the cardiac event. At baseline and after 1, 2, 4, 6, 9, 12, and 24 months of follow-up, the participants completed the Primary Care Evaluation of Mental Disorder (PRIME-MD) and the Hospital Anxiety and Depression Scale to establish the presence of a depressive episode and its severity. During the follow-up, 61 (22.8%) participants developed a depressive episode. Temperamental risk factors for incident depression were scored high on novelty seeking and harm avoidance at the TCI. Given the detrimental effect of depression on cardiac prognosis, clinicians should take temperament variables into account when determining the treatment plans of their patients with ACS.

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Depression After First Hospital Admission for Acute Coronary Syndrome: A Study of Time of Onset and Impact on Survival

Cited by 37 publications

References 28 publications

Anxiety, depression, and cardiac outcomes after a first diagnosis of acute coronary syndrome.

Anxiety, depression, and cardiac outcomes after a first diagnosis of acute coronary syndrome.

Hubungan Antara Depresi dan Ansietas Dengan Major Adverse Cardiac Event (MACE) Dalam 7 Hari Pada Pasien Sindrom Koroner Akut di RSCM

Temperament and Depression After a First Acute Coronary Syndrome

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