Depression and cancer mortality: a meta-analysis

Pinquart, Martin; Duberstein, Paul R.

doi:10.1017/s0033291709992285

Cited by 898 publications

(735 citation statements)

References 104 publications

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“…Depressed mood is known to be associated with CHD (34), cancer (35), diabetes (36), and other conditions. However, in the present analyses, the protective effect of PA remained after controlling for depression and EMA negative affect.…”

Section: Discussionmentioning

confidence: 99%

Positive affect measured using ecological momentary assessment and survival in older men and women

Steptoe

Wardle

2011

Proc. Natl. Acad. Sci. U.S.A.

152

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Links between positive affect (PA) and health have predominantly been investigated by using measures of recollected emotional states. Ecological momentary assessment is regarded as a more precise measure of experienced well-being. We analyzed data from the English Longitudinal Study of Aging, a representative cohort of older men and women living in England. PA was assessed by aggregating momentary assessments over a single day in 3,853 individuals aged 52 to 79 y who were followed up for an average of 5 y. Respondents in the lowest third of PA had a death rate of 7.3%, compared with 4.6% in the medium-PA group and 3.6% in the high-PA group. Cox proportional-hazards regression showed a hazard ratio of 0.498 (95% confidence interval, 0.345-0.721) in the high-PA compared with the low-PA group, adjusted for age and sex. This was attenuated to 0.646 (95% confidence interval, 0.436-0.958) after controlling for demographic factors, negative affect, depressed mood, health indicators, and health behaviors. Negative affect and depressed mood were not related to survival after adjustment for covariates. These findings indicate that experienced PA, even over a single day, has a graded relationship with survival that is not caused by baseline health status or other covariates. Momentary PA may be causally related to survival, or may be a marker of underlying biological, behavioral, or temperamental factors, although reverse causality cannot be conclusively ruled out. The results endorse the value of assessing experienced affect, and the importance of evaluating interventions that promote happiness in older populations.positive well-being | mortality | aging S ubjective well-being is being increasingly seen as an indicator of societal progress (1), and some countries are beginning to establish national well-being surveys (2). There is evidence that positive affective states and other measures of well-being are associated prospectively with longer survival and reduced risk of diseases of older age (3-9). Effects are maintained after initial health status and established risk factors are taken into account, and may also be independent of negative states such as depression (3, 10).To date, studies relating positive well-being with mortality have mainly relied on assessments of recollected emotional states, in which people are asked to rate their feelings of happiness or well-being in general, either without any time frame (5,6,9,11,12) or over a specific time period such as the previous 4 wk (4,8,10,13,14). Psychological research has established that recollected affect may diverge from actual experience because it is influenced by errors in recollection, recall biases, focusing illusions, and salient memory heuristics (15,16). This "memoryexperience gap" between life as it is remembered and life as it is experienced may be important to the processes through which the past impacts on future behavior (17).Methods of overcoming the limitations of retrospective measures include the use of ecological momentary assessment (EMA) (18), ...

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Section: Discussionmentioning

confidence: 99%

Positive affect measured using ecological momentary assessment and survival in older men and women

Steptoe

Wardle

2011

Proc. Natl. Acad. Sci. U.S.A.

152

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“…Using standard statistical software (SPSS, version 16, SPSS Inc., Chicago, IL), we first performed two-sided independent samples t-tests (for continuous variables) and 2 tests or Fisher's exact tests (for categorical variables) to evaluate preliminary differences between individuals with wild-type EGFR and those with EGFR mutations in demographic, clinical, and behavioral characteristics (depression severity and rate of probable major depressive disorder cases). In the event of any significant group difference in depression severity, we planned multiple linear regression analyses to evaluate whether or not the difference persisted after controlling for gender, performance status, and smoking history.…”

Section: Discussionmentioning

confidence: 99%

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Pirl¹,

Traeger²,

Greer³

et al. 2011

The Oncologist

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Introduction. Depression appears to be associated with worse survival from cancer, but underlying mechanisms for this association are unknown. In the present study, we explored the degree to which tumor genotype may be associated with depression in patients with non-small cell lung cancer (NSCLC). We examined differences in depression severity and rates of positive screens for major depressive disorder among newly diagnosed patients with stage IV NSCLC and known epidermal growth factor receptor (EGFR) genotype.Methods. Newly diagnosed patients (n ‫؍‬ 53) with metastatic NSCLC attending an initial thoracic oncology consultation completed self-report questionnaires regarding demographics, smoking behavior, and depression before meeting with their oncologist. Biopsy samples were subsequently genotyped, including screening for EGFR mutations. We conducted a retrospective chart review to obtain clinical data, in-

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“…Numbers of studies reported that depressed patients tend to be less proactive in seeking more aggressive treatments, and have severe symptoms, poor response to systemic therapy, long recovery times and poor outcomes (Walker et al, 1999 RESEARCH COMMUNICATION Colleoni et al, 2000;Hirschfeld, 2001). In addition, management of depression and anxiety leads to reduction in disease progression, improvement in survival rates, reduction in healthcare costs and improvement in quality of life (Frick et al, 2007;Satin et al, 2009;Pinquart and Duberstein, 2010).…”

Section: Introductionmentioning

confidence: 99%

Interaction of Coping Styles and Psychological Stress on Anxious and Depressive Symptoms in Chinese Breast Cancer Patients

Wang

Wang²,

Peng³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Purpose: This study aimed to assess possible interactive effects of coping styles and psychological stress on depression and anxiety symptoms in Chinese women shortly after diagnosis of breast cancer. Methods: Four hundred and one patients with breast cancer were face-to-face interviewed by trained research staff according to a standardized questionnaire including information on socio-demographic characteristics, psychological stress, coping styles, and anxiety and depressive symptoms. Interactive effects were assessed by hierarchical multiple regression analyses. Results: There were significant associations of the four domains of psychological stress with anxiety and depressive symptoms except for the relationship between "worrying about health being harmed" and depressive symptoms. "Abreaction coping behavior" and "escaping coping behavior" significantly increased the level of both anxiety and depressive symptoms; whereas an "active coping style" reswulted in significant decrease. The interaction of "active coping behavior" with "worrying about health being harmed" significantly increased the risk of the anxiety symptoms, while adopting "self-relaxing coping behavior" was associated with significant decrease. The interaction of "worry about daily life and social relationship being restricted" with "escaping coping behavior" significantly increased the risk of the depressive symptoms. Conclusions: The results of this study suggest that certain coping styles might moderate the association of psychological stress with anxiety and depressive symptoms in Chinese women with breast cancer.

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Depression and cancer mortality: a meta-analysis

Abstract: Background-The goal of the present study was to analyze associations between depression and mortality of cancer patients and to test whether these associations would vary by study characteristics.

Cited by 898 publications

References 104 publications

Positive affect measured using ecological momentary assessment and survival in older men and women

Positive affect measured using ecological momentary assessment and survival in older men and women

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Interaction of Coping Styles and Psychological Stress on Anxious and Depressive Symptoms in Chinese Breast Cancer Patients

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