Depression and Elevated Inflammation Among Chinese Older Adults: Eight Years After the 2003 SARS Epidemic

Wang, Haowei; Stokes, Jeffrey E.; Burr, Jeffrey A.

doi:10.1093/geront/gnaa219

Cited by 10 publications

(13 citation statements)

References 39 publications

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“…The lung and immune system are the main target organs of SARS and COVID-19, manifesting focal and patchy necrosis of lymph nodes and spleens, together with remarkable decreases in lymphocyte counts (81)(82)(83). COVID-19 has this kind of performance, but it is not as obvious as SARS.…”

Section: Crp and Other Viral Infections Crp And Sarsmentioning

confidence: 99%

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

2021

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Severe coronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan dysfunction. It has been documented that severe COVID-19 is associated with higher levels of inflammatory mediators than a mild disease, and tracking these markers may allow early identification or even prediction of disease progression. It is well known that C-reactive protein (CRP) is the acute-phase protein and the active regulator of host innate immunity, which is highly predictive of the need for mechanical ventilation and may guide escalation of treatment of COVID-19-related uncontrolled inflammation. There are numerous causes of an elevated CRP, including acute and chronic responses, and these can be infectious or non-infectious in etiology. CRP are normally lacking in viral infections, while adaptive immunity appears to be essential for COVID-19 virus clearance, and the macrophage activation syndrome may explain the high serum CRP contents and contribute to the disease progression. Nevertheless, for the assessment of host inflammatory status and identification of viral infection in other pathologies, such as bacterial sepsis, the acute-phase proteins, including CRP and procalcitonin, can provide more important information for guiding clinical diagnosis and antibiotic therapy. This review is aimed to highlight the current and most recent studies with regard to the clinical significance of CRP in severe COVID-19 and other viral associated illnesses, including update advances on the implication of CRP and its form specifically on the pathogenesis of these diseases. The progressive understanding in these areas may be translated into promising measures to prevent severe outcomes and mitigate appropriate treatment modalities in critical COVID-19 and other viral infections.

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Section: Crp and Other Viral Infections Crp And Sarsmentioning

confidence: 99%

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

2021

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“…The vast majority of residents have cognitive disorders ( Helvik et al, 2015 , Nuutinen et al, 2020 ) which are likely to affect their ability to comprehend the pandemic and the visiting restrictions. It is known that social isolation increases morbidity and mortality ( Holt-Lunstad, 2018 ) and, as one might assume, the first studies on the lockdown have reported negative impacts on the well-being of older adults (e.g., ( Macdonald and Hülür, 2021 , Kim and Jung, 2021 , Wang et al, 2021 )). Brooks et al ( Brooks et al, 2020 ) identified post-traumatic stress symptoms, confusion, and anger in residents, whereas Lima et al ( Lima et al, 2020 ) found that separation from loved ones led to despair among residents, and the feeling that the world was ending.…”

Section: Introductionmentioning

confidence: 99%

The impact of Covid-19-related distancing on the well-being of nursing home residents and their family members: a qualitative study

Paananen

Rannikko

Harju

et al. 2021

International Journal of Nursing Studies Advances

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Objectives: The aim of this study is to examine the consequences of Covid-19-related isolation and social restrictions on the well-being of nursing home residents and their family members, and to analyze how distancing has affected the relationships of family members with residents and the nursing home staff. Design: The data consist of 41 thematic one-on-one interviews conducted during May–December 2020 with family members of nursing home residents. Convenience sampling was utilized by asking several nursing homes in different parts of Finland to relay a contact request from the researchers to the residents’ family members. The main themes of the interviews were lockdown and visiting restrictions. Subthemes included the frequency of visits, other means of interaction, changes in the relationships of family members with their loved ones and with nursing home staff, and the feelings aroused by the situation. The interviews were audio recorded and transcribed verbatim, resulting in 794 pages of data. Method: The qualitative study uses inductive content analysis. NVivo12 software facilitated the systematic coding of the data. Results: According to the family members, distancing aggravated the residents’ pre-existing conditions: they reported a sudden progression in memory disorders and significant deterioration in physical abilities, for example. Both residents and family members experienced anxiety, grief, and severe stress, and family members expressed concern that residents might die due to a lack of social contact and activity. Family members were also frustrated about not being able to touch their relatives or participate in their care, and therefore sometimes thought that their visits were useless. New forms of interaction with family members, introduced by the nursing homes, were appreciated. However, some family members perceived the interactional protocols as unfair and complained about insufficient information. Conclusions: The findings underline the need for nursing homes to implement a good interactional protocol. Overall, the results show that the measures taken to protect residents’ health during the Covid-19 outbreak were short-sighted in terms of the social dimension of well-being. It is therefore important to continue developing safe and humane solutions for interaction when social restrictions are in place. Tweetable abstract: Covid-19-related distancing has caused anxiety, grief, and severe stress for nursing home residents and their family members.

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“…Lett., 2021, 8(4): [20][21][22][23][24][25][26] care services in the community and due to an increase in their population, demand for their services is increasingly growing. Their treatment differs from other age groups so that the cost of treatment in the elderly is twice that of a young person [4]. Depression is more common in the elderly than the general population, and various studies have reported the prevalence of depression in the elderly at 25 to 50 percent.…”

Section: Pourshams and Shhrooiementioning

confidence: 99%

Investigating the Prevalence and Risk Factors of Depression Disorders in the Elderly: 2019

Pourshams¹,

Shhrooie²

2021

Entomol. Appl. Sci. Lett

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By identifying the risk factors and the prevalence of depression, more accurate planning can be performed for its early diagnosis, leading to a reduced period of depression, reduced complications, and reduced treatment costs, imposed on the patient and medical system. The present study aimed to Investigating the Prevalence and Risk Factors of Depression Disorders in the Elderly. The present study was descriptiveanalytical. The statistical population of the present study consisted of all elderly (44 people) living in a nursing home in Behbahan in the spring of 2019. Data were collected using a standard geriatric depression scale (GDS) and a structured clinical interview conducted by the researcher. Data were analyzed in SPSS22 software and descriptive and inferential statistics. Based on the results, 27.29% of the elderly had low depression and 72.71% had high depression, 38.64% were over 70 years old and 40.90% were male, and 36.40% had a diploma or less. There was a significant relationship between the previous history of chronic disease and the prevalence of depression in the elderly (P <0.05). There was a significant relationship between age, length of stay, family support, marital status, previous history of chronic disease, and prevalence of depression in the elderly (P <0.05). Since geriatric depression is spreading, it is recommended that an adequate budget be allocated to equip and provide nursing homes following the standards. Also, the use of geriatric technologies such as robots and intelligent sensors can monitor the medical care of the elderly well.

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Depression and Elevated Inflammation Among Chinese Older Adults: Eight Years After the 2003 SARS Epidemic

Cited by 10 publications

References 39 publications

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

The impact of Covid-19-related distancing on the well-being of nursing home residents and their family members: a qualitative study

Investigating the Prevalence and Risk Factors of Depression Disorders in the Elderly: 2019

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