Depression, delusions, and suicide

Roose, Steven P.; Glassman, Alexander H.; Walsh, B Timothy; Woodring, S.; Vital-Herne, J

doi:10.1176/ajp.140.9.1159

Cited by 161 publications

(25 citation statements)

References 18 publications

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“…Botswick et al 14 also reported that impulsivity, aggression and psychosis increased in attempters. Roose et al 15 concluded that delusional, depressed patients were five times more likely to commit suicide than non-delusional ones.…”

Section: Discussionmentioning

confidence: 99%

Suicidal ideation and attempts in patients with major depression: Sociodemographic and clinical variables

Srivastava

Kumar

2005

Indian J Psychiatry

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Background:There is a high risk of suicidal attempt in patients with depression. This risk varies according to the sociodemographic status and clinical presentation.Aim:To assess the prevalence of suicidal ideation and attempt in patients with major depressive disorder, and to find the correlation between the two.Methods:Sixty patients with major depressive disorder having suicidal ideation were recruited in the study. Of these, 10 had a history of suicidal attempt made in the past or current episode. Sociodemographic details were evaluated and the Hamilton Rating Scale for Depression (HAM-D) was administered.Results:Analysis of the data showed that the incidence of suicidal attempt was 16.6% in patients with suicidal ideation. Statistically, a higher risk of suicidal attempt was found in individuals <30 years of age. Single men, married women and students were more likely to attempt suicide; higher education was also a vulnerability factor. Attempters scored significantly higher in severity of suicidal ideation, agitation and paranoid symptoms whereas among non-attempters, hypochondriasis and general somatic symptoms were more often present.Conclusion:All patients expressing suicidal ideation do not attempt suicide. Young patients with depression, especially unmarried men, married women and students, having severe suicidal ideation with agitation or paranoid symptoms are more likely to attempt suicide.

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Section: Discussionmentioning

confidence: 99%

Suicidal ideation and attempts in patients with major depression: Sociodemographic and clinical variables

Srivastava

Kumar

2005

Indian J Psychiatry

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“…The rationale for selecting these 16 variables was based on previous findings that reported the following risk factors for suicide attempts or suicide, i.e., younger age [ 21 , 22 ], female gender [ 21 , 22 ], low education level [ 21 , 22 ], unmarried status [ 21 , 22 ], unemployment [ 22 , 23 ], living alone [ 24 , 25 ], past suicidal behaviors [ 24 , 26 ], family history of psychiatric disorders [ 27 , 28 ] and suicide deaths [ 27 ], bipolarity [ 29 , 30 ], agitation during a depressive episode [ 31 , 32 ], psychotic features [ 33 , 34 ], physical diseases [ 35 , 36 ], alcohol abuse [ 24 , 37 ], cluster B personality disorders [ 38 , 39 ], and ASD.…”

Section: Methodsmentioning

confidence: 99%

Comorbid atypical autistic traits as a potential risk factor for suicide attempts among adult depressed patients: a case–control study

Takara

Kondo

2014

Ann Gen Psychiatry

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BackgroundThe present study aims to examine if autism spectrum disorder (ASD) is a risk factor for suicide attempts among adult depressed patients and to elucidate the characteristics of suicide attempts in adult depressed patients with ASD.MethodsWe conducted a case–control study. Subjects consisted of 336 retrospectively recruited first-time visit patients to our outpatient clinic with a current major depressive episode; 31 of the 336 patients had attempted suicide. The demographic backgrounds (i.e., age, gender, personal/family history of suicidality); specific psychopathology like bipolarity, agitation, and psychotic features; and comorbidity such as physical diseases, alcohol abuse, cluster B personality disorder, and ASD including pervasive developmental disorder not otherwise specified (PDD-NOS) were examined as potential risk factors for suicide attempts. We compared these variables between the suicide attempters and non-attempters. In addition, we compared suicide attempters to non-attempters within the ASD group and non-ASD group. Binary logistic regression analysis was performed using the significant independent variables from the comparisons between the suicide attempters and non-attempters, and the odds ratios (OR) and 95% confidence intervals (CI) were calculated.ResultsLogistic regression analysis demonstrated that agitation during a depressive episode (OR = 7.15, 95% CI = 2.88–17.74), past suicidal behaviors (OR = 4.32, 95% CI =1.70–10.98), and comorbid PDD-NOS (OR = 4.04, 95% CI = 1.20–13.54) were significantly associated with suicide attempts. The most prevalent suicidal method was drug overdose (59.1%) among non-ASD attempters while hanging was the most prevalent (44.4%) in ASD attempters.ConclusionsDepressed adults with comorbid atypical autistic traits are at higher risk for suicide attempts and may engage in methods that are more lethal.

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“…A retrospective review concluded that depressed patient with psychotic delusion can be five times more likely to commit suicide than a nondelusional one [71]. Overall, delusional depression has a poorer prognosis than nonpsychotic depression [72], and is less responsive to antidepressants [73].…”

Section: Evidence Base For Ect Effectiveness Efficacy and Tolerabilitymentioning

confidence: 99%

Current electroconvulsive therapy practice and research in the geriatric population

2014

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SUMMARY Electroconvulsive therapy (ECT) is utilized worldwide for various severe and treatment-resistant psychiatric disorders. Research studies have shown that ECT is the most effective and rapid treatment available for elderly patients with depression, bipolar disorder and psychosis. For patients who suffer from intractable catatonia and neuroleptic malignant syndrome, ECT can be life saving. For elderly patients who cannot tolerate or respond poorly to medications and who are at a high risk for drug-induced toxicity or toxic drug interactions, ECT is the safest treatment option. Organic causes are frequently associated with late-life onset of neuropsychiatric conditions, such as parkinsonism, dementia and stroke. ECT has proven to be efficacious even when these conditions are present. During the next decade, research studies should focus on the use of ECT as a synergistic therapy, to enhance other biological and psychological treatments, and prevent symptom relapse and recurrence.

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Depression, delusions, and suicide

Cited by 161 publications

References 18 publications

Suicidal ideation and attempts in patients with major depression: Sociodemographic and clinical variables

Suicidal ideation and attempts in patients with major depression: Sociodemographic and clinical variables

Comorbid atypical autistic traits as a potential risk factor for suicide attempts among adult depressed patients: a case–control study

Current electroconvulsive therapy practice and research in the geriatric population

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