Depression, Nutritional Status, and Serum Cytokines in Peritoneal Dialysis Patients: Is There a Relationship?

Kalender, Betül; Dervişoğlu, Erkan; Şengül, Erkan; Ozdemir, Aytul Corapcioglu; Akhan, Sıla; Yalug, Irem; Uzun, Hafize

doi:10.1177/089686080702700523

Cited by 22 publications

(41 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, no significant correlations were found between depression scores and serum IL-6 levels in the entire cohort or patient subgroup analysis. Similarly, the studies by Kalender et al 61 on 42 PD patients and Cilan et al 63 on 40 HD patients did not find significant difference in serum IL-6 levels in depressed and nondepressed patients. Montinaro et al evaluated the production of IL-6 by cultured leukocytes of 30 HD and 20 CKD stage 1-2 patients.…”

Section: Depression and Il-6mentioning

confidence: 72%

“…Collectively, 5 studies showed the significant difference, 64,[86][87][88][89] whereas equal number of studies did not show the difference, 17,[61][62][63]90 in serum IL-6 levels between CKD and ESRD patients with and without depressive symptoms. In evaluation of these two groups of studies, some issues should be considered.…”

Section: Depression and Il-6mentioning

confidence: 91%

“…52 In 42 adult patients undergoing PD, Kalender et al did not find significant differences in serum IL-1 levels between patients with and without depressive symptoms. 61 Also, Montinaro et al did not find significant differences in IL-1β production by cultured leukocytes in 30 HD and 20 CKD stage 1-2 patients with and without symptoms of depression. 62 Likewise, Cilan et al did not find significant difference in serum IL-1 levels among 40 HD patients with and without depression.…”

Section: Depression and Il-1mentioning

confidence: 93%

“…Taken together, as shown in Table 1, 4 studies evaluated the difference in serum levels of IL-1 in CKD and ESRD patients with and without depression. [61][62][63][64] Various measurement tools have been used to assess depression symptoms in these patients. However, all studies have shown that serum levels of IL-1 were not different between these patients with and without depression.…”

Section: Depression and Il-1mentioning

confidence: 99%

“…64,[86][87][88][89] On the contrary, equal number of studies also did not find such a significant difference. 17,[61][62][63]90 Prospectively, Simic Ogrizovic et al followed up 128 dialysis patients (77 HD and 51 PD) over 36 months. 86 They found that depressed patients had significantly higher serum IL-6 levels than patients without depression.…”

Section: Depression and Il-6mentioning

confidence: 99%

See 4 more Smart Citations

Association between depression and inflammatory/anti‐inflammatory cytokines in chronic kidney disease and end‐stage renal disease patients: A review of literature

Taraz

Dashti‐Khavidaki

2014

Hemodialysis International

View full text Add to dashboard Cite

Depression is a common psychiatric disorder in patients with advanced chronic kidney diseases (CKDs). Strong correlation has been reported between depression and patients' morbidity and mortality among dialysis patients. On the contrary, chronic inflammation may be a major contributor to morbidity and mortality in these patients. Elevated plasma levels of proinflammatory cytokines, especially C-reactive protein and interleukin (IL)-6, have been correlated with cardiovascular events, hospitalization, and all-cause and cardiovascular-associated mortality in dialysis patients. Studies suggested that inflammation-mediated atherosclerotic cardiovascular diseases are the possible reasons for depression-induced mortality among patients without renal diseases. Several studies found significant elevations in circulating levels of proinflammatory cytokines, particularly IL-6 and tumor necrosis factor-α, in patients with major depression. Furthermore, depressive mood and behaviors, including sadness and suicidal ideation, were observed in patients who received repeated injections of recombinant cytokines. A thorough literature review indicates that while depressive symptoms and elevated inflammatory cytokine levels coexist in CKD and dialysis patients, their association is uncertain. Depression seems to be more associated with elevated serum levels of IL-6 than other cytokines in these patients. Further studies are needed to clarify the possibility of a causal relationship between inflammation and depressive symptoms in CKD and dialysis patients.

show abstract

Section: Depression and Il-6mentioning

confidence: 72%