Depression presentations, stigma, and mental health literacy: A critical review and YouTube content analysis

Devendorf, Andrew; Bender, Ansley; Rottenberg, Jonathan

doi:10.1016/j.cpr.2020.101843

Cited by 59 publications

(55 citation statements)

References 93 publications

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“…Overall, this representative study provides evidence that OWB is a realistic goal for some patients, particularly in the aftermath of alcohol use disorders or depression. These findings, if replicated, challenge public stereotypes that these conditions are overwhelmingly chronic, intractable, and preclude long-term well-being (Devendorf, Bender, & Rottenberg, 2020;Stacy & Rosenheck, 2019). Based on these data, symptomatic recovery may be a more realistic goal for patients with a history of suicidal ideation or bipolar disorders.…”

Section: Discussionmentioning

confidence: 70%

Optimal well-being after psychopathology: Prevalence and correlates

Devendorf¹,

Rum²,

Kashdan³

et al. 2022

Preprint

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Optimal functioning after psychopathology is understudied. We report the prevalence of optimal well-being (OWB) following recovery after depression, suicidal ideation, generalized anxiety disorder, bipolar disorder, and substance use disorders. Using a national Canadian sample (N = 23,491), we operationalized OWB as absence of 12-month psychopathology and scoring above the 25th national percentile on psychological well-being and functioning measures. Compared with 24.1% of participants without a history of psychopathology, 9.8% of participants with a lifetime history of psychopathology met OWB. Adults with a history of substance use disorders (10.2%) and depression (7.1%) were the most likely to report OWB. Persons with anxiety (5.7%), suicidal ideation (5.0%), bipolar 1 (3.3%), and bipolar 2 (3.2%) were less likely to report OWB. Having just one lifetime disorder increased the odds of OWB by 4.2 times relative to multiple lifetime disorders. While psychopathology substantially reduces the probability of OWB, many individuals with psychopathology attain OWB.

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Section: Discussionmentioning

confidence: 70%

Optimal well-being after psychopathology: Prevalence and correlates

Devendorf¹,

Rum²,

Kashdan³

et al. 2022

Preprint

Self Cite

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“…These theories informed the development of a similar conceptual framework to Devendorf et al, (2020), with the notable addition of Link and Phelan's (2001) stigmatisation process (see Fig. 1).…”

Section: Theoretical and Conceptual Frameworkmentioning

confidence: 99%

Exploring Continuum and Categorical Conceptualisations of Mental Health and Mental Illness on Australian Websites: A Systematic Review and Content Analysis

Fernandez

Singh

Deane

et al. 2022

Community Ment Health J

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It is important to explore the types of conceptualisations and causes presented in online mental health promotion given the implications that these presentations may have on mental health stigma. This study systematically reviewed 92 Australian webpages focused on either mental health, mental illness, depression, or schizophrenia, to explore the types of conceptualisations and aetiologies presented. A minority of mental health and mental illness webpages (n = 8, 8.70%) explicitly presented continuum conceptualisations, with none providing explicit categorical conceptualisations. No depression or schizophrenia webpages presented explicit conceptualisations of any kind. All four webpage foci had a greater proportion of continuum than categorical conceptualisations. Moreover, both depression and schizophrenia webpages presented many mixed conceptualisations which included both continuum and categorical messaging. Most webpages mentioned biological and social causes equally across webpage foci. These findings suggest that Australian mental health websites predominantly present continuum conceptualisations of mental health and mental illness.

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“…Depression is a common mental disorder characterized by high morbidity and suicidal risk ( Auerbach et al, 2018 ; Devendorf et al, 2020 ). Previous studies have shown that depression is a complex disorder involving multiple genes ( Fan et al, 2020 ; Kang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data

Ren

Li²,

Wei³

et al. 2022

Front. Genet.

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Deletion of brain-derived neurotrophic factor (BDNF) and upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) are associated with depression severity in animals. The neurotransmitter hypothesis of depression at the transcriptomic level can be tested using BDNF- and IDO1-knockout mouse models and RNA-seq. In this study, BDNF+/−, IDO1−/−, and chronic ultra-mild stress (CUMS)-induced depression mouse models and controls were developed, and the differentially expressed genes were analyzed. Furthermore, the ceRNA package was used to search the lncRNA2Target database for potential lncRNAs. Finally, a protein–protein interaction (PPI) network was constructed using STRINGdb. By comparing the control and CUMS model groups, it was found that pathway enrichment analysis and ceRNA network analysis revealed that most differentially expressed genes (DEGs) were associated with protection of vulnerable neuronal circuits. In addition, we found the enriched pathways were associated with nervous system development and synapse organization when comparing the control and BDNF+/−model groups. When replicating the neurotransmitter disruption features of clinical patients, such comparisons revealed the considerable differences between CUMS and knockdown BDNF models, and the BDNF+/−model may be superior to the classic CUMS model. The data obtained in the present study implicated the potential DEGs and their enriched pathway in three mouse models related to depression and the regulation of the ceRNA network-mediated gene in the progression of depression. Together, our findings may be crucial for uncovering the mechanisms underlying the neurotransmitter hypothesis of depression in animals.

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Depression presentations, stigma, and mental health literacy: A critical review and YouTube content analysis

Cited by 59 publications

References 93 publications

Optimal well-being after psychopathology: Prevalence and correlates

Optimal well-being after psychopathology: Prevalence and correlates

Exploring Continuum and Categorical Conceptualisations of Mental Health and Mental Illness on Australian Websites: A Systematic Review and Content Analysis

Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data

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