Depression, Quantified Medication Adherence, and Quality of Life in Renal Transplant Candidates and Recipients

Robiner, William N.; Petrik, Megan L.; Flaherty, Nancy; Fossum, Thyra A.; Freese, Rebecca; Nevins, Thomas E.

doi:10.1007/s10880-021-09792-2

Cited by 4 publications

(9 citation statements)

References 75 publications

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“…González-De-Jesús et al (2011) found the decreasing trend in depressive symptom scores from pre-KT to 6 months post-KT using the Hospital Anxiety Depression Scale (HADS) and Symptom Checklist-90, but only latter scores reached statistical significance. A decrease in depressive symptoms was also observed after KT in Robiner et al’s (2021) study. Depressive symptoms were improved at 6 months post-KT as measured by the Beck Depression Inventory-II and the Millon Clinical Multiaxial Inventory III-Major Depression Scale, but only former results reported significant changes in depressive symptom scores.…”

Section: Resultssupporting

confidence: 56%

“…The studies were conducted in Europe ( n = 19), Asia ( n = 6), the Middle East ( n = 5), the United States ( n = 4), and Latin America ( n = 4). Two studies employed a longitudinal design to follow up from pre-KT to the post-KT period (González-De-Jesús et al, 2011; Robiner et al, 2021). The remaining 36 studies employed cross-sectional designs.…”

Section: Resultsmentioning

confidence: 99%

“…In Vásquez et al’s (2013) study, 13.8% of KT recipients reported depressive symptoms using self-reported instruments, and a comparable percentage of KT recipients (11.8%) were diagnosed with clinical depression based on a structured diagnostic interview. Two studies examined changes in depressive symptom score from pre- to post-KT using self-reported questionnaires and showed mixed findings (González-De-Jesús et al, 2011; Robiner et al, 2021). González-De-Jesús et al (2011) found the decreasing trend in depressive symptom scores from pre-KT to 6 months post-KT using the Hospital Anxiety Depression Scale (HADS) and Symptom Checklist-90, but only latter scores reached statistical significance.…”

Section: Resultsmentioning

confidence: 99%

“…Reber et al (2016) reported that a moderate level of depressive symptoms was associated with nonadherence with a medium effect size. Robiner et al (2021) conducted a longitudinal study that examined relationships of depressive symptoms at pre- and post-KT to medication adherence in KT recipients, depressive symptoms before KT were negatively associated with post-KT medication adherence.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, three studies confirmed this relationship using Spearman and Pearson correlation and multiple linear regression (Látos et al, 2016; Vásquez et al, 2013; Zimmermann et al, 2016). In addition, associations between depressive symptoms and fatigue were significant in seven studies using Pearson and Spearman correlation, multiple linear and logistic regression, and mediation analysis (Chan et al, 2013, 2016; Goedendorp et al, 2013; Robiner et al, 2021; Rocha et al, 2020; Rodrigue et al, 2011; Zhang et al, 2019). Specifically, depressive symptoms were associated with four fatigue dimensions (general and physical fatigue, reduced activity and motivation) but not with mental fatigue (Chan et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sung¹,

Hershberger

Lockwood³

2022

West J Nurs Res

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Sickness symptoms (depressive symptoms, anxiety, and fatigue) are common among people with chronic illness, often presenting as a symptom cluster. Sickness symptoms persist in many patients with chronic kidney disease, even after kidney transplantation (KT); however, little is known about sickness symptom-induced burden in KT recipients. This scoping review synthesizes available evidence for sickness symptoms in KT recipients, including findings on symptom prevalence, predictors, outcomes, interrelationships, and clustering. Among 38 reviewed studies, none identified sickness symptoms as a cluster, but we observed interrelationships among the symptoms examined. Fatigue was the most prevalent sickness symptom, followed by anxiety and depressive symptoms. Predictors of these symptoms included demographic, clinical, and psychosocial factors, and health-related quality of life was the most researched outcome. Future research should use common data elements to phenotype sickness symptoms, include biological markers, and employ sophisticated statistical methods to identify potential clustering of sickness symptoms in KT recipients.

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sung¹,

Hershberger

Lockwood³

2022

West J Nurs Res

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Do pre‐transplant cultural factors predict health‐related quality of life after kidney transplantation?

Loor,

Ford,

Leyva

et al. 2024

Clinical Transplantation

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BackgroundPost‐transplant health‐related quality of life (HRQOL) is associated with health outcomes for kidney transplant (KT) recipients. However, pretransplant predictors of improvements in post‐transplant HRQOL remain incompletely understood. Namely, important pretransplant cultural factors, such as experience of discrimination, perceived racism in healthcare, or mistrust of the healthcare system, have not been examined as potential HRQOL predictors. Also, few have examined predictors of decline in HRQOL post‐transplant.MethodsUsing data from a prospective cohort study, we examined HRQOL change pre‐ to post‐transplant, and novel cultural predictors of the change. We measured physical, mental, and kidney‐specific HRQOL as outcomes, and used cultural factors as predictors, controlling for demographic, clinical, psychosocial, and transplant knowledge covariates.ResultsAmong 166 KT recipients (57% male; mean age 50.6 years; 61.4% > high school graduates; 80% non‐Hispanic White), we found mental and physical, but not kidney‐specific, HRQOL significantly improved post‐transplant. No culturally related factors outside of medical mistrust significantly predicted change in any HRQOL outcome. Instead, demographic, knowledge, and clinical factors significantly predicted decline in each HRQOL domain: physical HRQOL—older age, more post‐KT complications, higher pre‐KT physical HRQOL; mental HRQOL—having less information pre‐KT, greater pre‐KT mental HRQOL; and, kidney‐specific HRQOL—poorer kidney functioning post‐KT, lower expectations for physical condition to improve, and higher pre‐KT kidney‐specific HRQOL.ConclusionsInstead of cultural factors, predictors of HRQOL decline included demographic, knowledge, and clinical factors. These findings are useful for identifying patient groups that may be at greater risk of poorer post‐transplant outcomes, in order to target individualized support to patients.

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Immunosuppressant medication behaviours in solid organ transplant recipients: a cross-sectional study from south-central China during COVID-19 reopening period

Zhao,

Dong,

Wang

et al. 2024

BMJ Open

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ObjectiveMedication non-adherence to immunosuppressants threatens allograft survival and function maintenance among solid organ transplant (SOT) recipients. This study aimed to investigate the prevalence of immunosuppressant medication non-adherence and associated factors during the COVID-19 reopening period among Chinese SOT recipients.DesignCross-sectional study.SettingSouth-central China.PopulationAdult patients who received SOT with functioning graft.MethodsSociodemographic questionnaire and scales to measure physical activity, depression and medication non-adherence were used to collect data. Logistic regression analysis was conducted to identify factors associated with medication non-adherence. Mediation and moderated mediation analyses were performed to examine the potential mechanisms influencing medication behaviour during the pandemic reopening period using SPSS PROCESS macro 4.3 software.ResultsA total of 1121 participants were recruited and the prevalence of medication non-adherence was 36.3% in this study. Recipients who were men, had a higher monthly income, lived alone, had received transplantation for a minimum of 3 years, had received COVID-19 vaccination and experienced depressive symptoms exhibited an increased risk of non-adherence. Contrarily, those who engaged in high-intensity physical activity exhibited a decreased risk. Physical activity was negatively associated with medication non-adherence (r=−0.124, p<0.001) with depression fully mediating this relationship (B=−0.014, 95% CI: −0.032 to –0.003). COVID-19 vaccination significantly moderated the relationship between physical activity and depression (B=−0.303, 95% CI: −0.515 to –0.090).ConclusionThis study investigated the prevalence of medication non-adherence among SOT recipients during the COVID-19 reopening period in China, its associated factors and a potential mechanism. Depression fully mediated the association between physical activity and medication non-adherence, and COVID-19 vaccination moderated the relationship between physical activity and depression. These findings provide some insights for managing medication behaviour when confronting public health emergencies. However, relationships displayed in the moderated mediation model should be tracked after returning to normal life and other potential relationships should be explored to deeply understand medication non-adherent behaviour.

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Depression, Quantified Medication Adherence, and Quality of Life in Renal Transplant Candidates and Recipients

Cited by 4 publications

References 75 publications

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Do pre‐transplant cultural factors predict health‐related quality of life after kidney transplantation?

Immunosuppressant medication behaviours in solid organ transplant recipients: a cross-sectional study from south-central China during COVID-19 reopening period

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