Depressive Symptoms and Chronic Obstructive Pulmonary Disease

Ng, Tze‐Pin; Niti, Mathew; Tan, Wan-Cheng; Cao, Zhenying; Ong, K. C. G.; Eng, Philip

doi:10.1001/archinte.167.1.60

Cited by 550 publications

(235 citation statements)

References 37 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…We found that psychological disorders such as depression and anxiety in subjects with COPD were significantly associated with all subscales of the SGRQ according to the simple correlation, but only anxiety disorders were independently associated with SGRQ total scores in linear regression analysis. Ng et al 25 reported that depressed subjects with COPD had significantly worse HRQOL in all subscales of the SGRQ. Andenaes et al 26 reported a significant relationship between depression scores and the respiratory-specific SGRQ impact subscale in subjects with COPD.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Quality of Life in Subjects With Stable COPD

et al. 2015

View full text Add to dashboard Cite

BACKGROUND: The purpose of this study was to assess the impact of bronchiectasis, anxiety and depression, and parameters of disease severity on health-related quality of life (HRQOL) in subjects with COPD. METHODS: Sixty-two subjects with stable COPD were selected for the study. The presence of bronchiectasis in all subjects with COPD was investigated by high-resolution computed tomography. Pulmonary function tests were performed. Dyspnea was assessed using the Modified Medical Research Council (MMRC) dyspnea scale. Psychological disorders were investigated using the Hospital Anxiety and Depression Scale (HADS), and the HRQOL was examined using the St George Respiratory Questionnaire (SGRQ). RESULTS: High-resolution computed tomography revealed that 44 of 62 (70.9%) subjects with COPD had bronchiectasis. There were no differences in pulmonary function tests, symptoms, activities, impact, SGRQ total scores, and HADS scores between COPD subjects with and without bronchiectasis. Pearson correlation analyses showed that there was no significant association between the presence of bronchiectasis, bronchial wall thickness, or severity of bronchial dilatation and all subscales of the SGRQ or HADS scores. Additionally, HADS scores showed significant positive association with all subscales of the SGRQ in all subjects. In linear regression analysis, a statistically significant relationship was found between the SGRQ total score and percent-of-predicted FEV 1 , percent-of-predicted diffusing capacity of the lung for carbon monoxide, MMRC score, and anxiety score, but the SGRQ total score was not associated with age, body mass index, total number of hospitalizations, P aO 2 , or depression score. CONCLUSIONS: The presence of bronchiectasis in subjects with COPD does not impact HRQOL and psychological disorders. However, disease severity, dyspnea levels, and anxiety scores predict poor HRQOL. Key words: chronic obstructive pulmonary disease (COPD); health-related quality of life (HRQOL); anxiety; depression; bronchiectasis. [Respir Care 2015;60(11):1585-1591

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Associated With Quality of Life in Subjects With Stable COPD

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The mortality and readmission rate among anxious and/or depressive COPD patients increases during the 30 days following hospitalisation [68]. The presence of depression has prognostic value, as shown in a study in COPD patients hospitalised for exacerbation [69]. Mortality following a COPD exacerbation was greater among the depressive patients.…”

Section: Anxiety and Depression Disordersmentioning

confidence: 96%

“…Indeed, anxiety was found to be related to increased risk of relapse after exacerbation [208] and hospital readmission [209]. The role of depression on exacerbation is less clear but it has prognostic value because it extends the duration of hospitalisation [69,210]. In the same way, metabolic syndrome has an impact in exacerbation.…”

Section: Copd Comorbidities Impact On Exacerbationsmentioning

confidence: 99%

Comorbidities of COPD

Cavaillès¹,

Brinchault-Rabin²,

Dixmier³

et al. 2013

Eur Respir Rev

419

285

View full text Add to dashboard Cite

By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly caused by COPD, whereas others, such as systemic venous thromboembolism, anxiety, depression, osteoporosis, obesity, metabolic syndrome, diabetes, sleep disturbance and anaemia, have no evident physiopathological relationship with COPD. The common ground between most of these extrapulmonary manifestations is chronic systemic inflammation.All of these diseases potentiate the morbidity of COPD, leading to increased hospitalisations and healthcare costs. They can frequently cause death, independently of respiratory failure. Comorbidities make the management of COPD difficult and need to be evaluated and treated adequately. @ERSpublications Extrapulmonary comorbidities are common in COPD and influence prognosis; we propose an exhaustive comorbidities review

show abstract

“…The first was conducted by Light evaluating the association between physical factors and depression in 1985 13 .Until 2007, most studies denied an association between depression and physical measurements of COPD. In contrast, most studies since 2008 have affirmed a positive association between depression and physical measurements of COPD.…”

Section: Discussionmentioning

confidence: 99%