Deracemization Enabled by Visible‐Light Photocatalysis

Abstract

Deracemization is an ideal but challenging strategy for the conversion of a racemic mixture into a single enantiomer. Recent studies have demonstrated that visible‐light photocatalysis could be utilized to promote selective deracemization of axially chiral allenes as well as cyclopropylquinolones and cyclic ureas with central chirality either through energy transfer or through a sequence of electron, proton, and hydrogen‐atom transfer.

Photochemically Induced Ring Opening of Spirocyclopropyl Oxindoles: Evidence for a Triplet 1,3‐Diradical Intermediate and Deracemization by a Chiral Sensitizer

“…Thereverse process,that is,aphotochemical deracemization, [6] however,i ss ynthetically very useful. Indeed, al arge number of chiral compounds are prepared in racemic form and need to be separated at al ater stage by sophisticated methods.…”

Symmetry Breaking of Phospholipids

“…[38,39] The hydrogen cyanide-cyanocuprate photochemistry have been proven to be effective for the synthesis in abiotic conditions of glyceraldehyde precursors starting the oxidoreduction of 1 into 2 then 3, respectively (Scheme 1). However, this system cannot lead to any chemical imbalance of 1 for the absence of any chiral inductor, irrespective that model reaction proven that deracemization or interconversion occur using photocatalysis [40].…”

Synthesis of CdS-loaded (CuC10H26N6)3(PW12O40)2 for enhanced photocatalytic degradation of tetracycline under simulated solar light irradiation

“…[14][15][16] As a typical chemical process, semiconductor photocatalysis distinguishes itself from other peers due to environmental friendliness, renewable utilization, and low cost. [17][18][19][20] For instance, the photocatalytic degradation of TC can be performed with existence of thickness-controllable Bi 24 O 31 Br 10 . 21 Perovskite oxide/g-C 3 N 4 photocatalysts were also developed, and a degradation rate of 81% was reached.…”