Deregulated expression of long non‐coding <scp>RNA UCA</scp>1 in multiple myeloma

Sedlaříková, Lenka; Gromesová, Barbora; Kubaczková, Veronika; Radová, Lenka; Filipova, Jana; Jarkovský, Jiří; Brožová, Lucie; Velichová, Roberta; Almáši, Martina; Penka, Miroslav; Bezděková, Renata; Štork, Martin; Adam, Zdeněk; Pour, Luděk; Krejčí, Marta; Kuglík, Petr; Hájek, Roman; Ševčı́ková, Sabina

doi:10.1111/ejh.12908

Cited by 44 publications

(34 citation statements)

References 48 publications

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“…14 NEAT1 acts as an oncogene in many types of cancers as in breast cancer, non-small-cell lung cancer (NSCLC), 15 that modulate cancer progression in renal cell carcinoma through epithelial mesenchymal transition (EMT) 16 and regulate miR-449b-5p/c-Met axis in glioma pathogenesis. 17 Meanwhile, NEAT1 is significantly downregulated in leukemia, multiple myeloma, [18][19][20] and acute promyelocytic leukemia. 18 The aim of the present study was to evaluate the relative expression level of serum NEAT and MiR-129-5p in HCC patients among Egyptian population and their relation with patient's clinical and biochemical investigations.…”

Section: Neat1mentioning

confidence: 99%

“…NEAT1 acts as an oncogene in many types of cancers as in breast cancer, non‐small‐cell lung cancer ( NSCLC), that modulate cancer progression in renal cell carcinoma through epithelial mesenchymal transition (EMT) and regulate miR‐449b‐5p/c‐Met axis in glioma pathogenesis . Meanwhile, NEAT1 is significantly downregulated in leukemia, multiple myeloma, and acute promyelocytic leukemia …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of serum long noncoding RNA NEAT and MiR‐129‐5p in hepatocellular carcinoma

et al. 2019

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Hepatocellular carcinoma (HCC) is one of the most prevalent form of cancer. Various long non coding RNA (lncRNAs) and micro RNA have been confirmed to have a role in the progression of HCC. Our aim was to investigate for the first time the expression profile of serum level of LNC NEAT (nuclear enrich abundant transcript) and MiR‐129‐5p in HCC patients and their relations with patient's clinical and biochemical investigations rather than previous studies on tissue cell lines. Our study includes 72 subjects divided into 36 as control subjects and 36 patients with HCC. Complete physical and laboratory investigations were done on all subjects. RNAs were extracted from sera of all subjects. RNAs were reversed transcribed into cDNAs using Qiagen, Valenica, CA. Quantitative PCR (qPCR) was performed using Rotor gene Q System (Qiagen). Relative NEAT1 expression level was significantly increased in serum of HCC patients 4.7 (1.31–6.82) (p < .0001). Meanwhile MiR‐129‐5p relative expression level was significantly decreased in serum of HCC patients 0.17 (0.14–20) (p < .0001). Also there was negative significant correlation between the expression level of LNC NEAT and MiR‐129‐5p in HCC group (p < .0001). ROC curve analysis revealed that LNC NEAT; AUC = 0.981, p < .0001, cutoff value (1.02), sensitivity 100%, specificity 88.9%. MiR‐129‐5p; AUC = 0.997, p < .0001, cutoff value (0.43), sensitivity 100%, specificity 97.2%. Serum LNC NEAT and MiR‐129‐5p could be used as potential biomarkers for HCC cancer diagnosis and prognosis.

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Section: Neat1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of serum long noncoding RNA NEAT and MiR‐129‐5p in hepatocellular carcinoma

et al. 2019

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“…14 Sedlarikova et al found that UCA1 was downregulated in MM patients, when compared to healthy donors. 58 Their results also revealed that higher levels of UCA1 were correlated to advanced ISS stage and 1q21 gain. Due to the fact that IL-6 contains a site for CREB binding, which results in the suppression of IL-6 autocrine secretion, the investigators assumed that higher UCA1 levels induce CREB suppression, and consequently, higher IL-6 secretion, which leads to the survival of MM cells, bone resorption, and M-Ig secretion.…”

Section: Uca1mentioning

confidence: 94%

“…In acute myeloid leukemia (AML), UCA1 promotes the proliferation of malignant cells by suppressing p27 kip1 . Sedlarikova et al found that UCA1 was downregulated in MM patients, when compared to healthy donors . Their results also revealed that higher levels of UCA1 were correlated to advanced ISS stage and 1q21 gain.…”

Section: Mechanisms Of Lncrnas In MMmentioning

confidence: 99%

The role of long non‐coding RNAs in multiple myeloma

Cui

Song

Fang

2019

European J of Haematology

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Multiple myeloma (MM) is still an incurable disease, and its pathogenesis involves cytogenetics and epigenetics. In recent years, the roles of long non‐coding RNAs (lncRNAs) in MM have been deeply studied by scholars. LncRNAs are defined as a class of non‐protein‐coding transcripts greater than 200 nucleotides in length, which are involved in a large spectrum of biological processes, including proliferation, differentiation, apoptosis, invasion, and chromatin remodeling. However, little is known about the specific mechanisms of these lncRNAs. They can act as oncogenic and/or tumor‐suppressive factors in the development and progression of MM. But that how do they work remains unclear. In this review, the recent progress in the study of functional lncRNAs associated with MM was summarized and the present knowledge about their expression and roles was discussed, to provide guidance for the in‐depth functional study of lncRNAs.

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“…LncRNA H19 was also upregulated in MM patients and cell lines, and the expression level in serum could assist clinical staging, which could roughly determine the severity of disease (Pan et al, ). LncRNA UCA1 was able to discriminate newly diagnosed MM patients and healthy donors with high sensitivity and specificity and higher levels were significantly associated with worse OS of MM patients during the 1–4 years follow‐up period (Sedlarikova et al, ).…”

Section: Values Of Targeting Ncrnas In MMmentioning

confidence: 99%

Emerging roles of noncoding RNAs in multiple myeloma: A review

Yang

Shen

et al. 2018

Journal Cellular Physiology

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Multiple myeloma (MM) is a hematologic malignancy characterized by unrestricted secretion of monoclonal immunoglobulin and uncontrolled plasma cell proliferation. Extra‐medullary infiltration and drug resistance are two major obstacles in the treatment of MM. To solve these problems, it is necessary to elucidate the underlying pathological mechanisms and find new therapeutic targets. Noncoding RNAs (ncRNAs), which were once considered “transcriptional noise,” have been recognized as crucial regulators in the process of tumorigenesis including MM. Increasing evidence has shown that ncRNAs participate in MM pathogenesis via a series of complex cellular or extracellular processes. This review article summarizes examples of ncRNAs involved in myelosis and discusses their potential as biomarkers and therapeutic targets in the diagnosis and treatment of myelosis.

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Deregulated expression of long non‐coding RNA UCA1 in multiple myeloma

Abstract: Our study suggests a possible prognostic impact of UCA1 expression levels on MM patients.

Cited by 44 publications

References 48 publications

Evaluation of serum long noncoding RNA NEAT and MiR‐129‐5p in hepatocellular carcinoma

Evaluation of serum long noncoding RNA NEAT and MiR‐129‐5p in hepatocellular carcinoma

The role of long non‐coding RNAs in multiple myeloma

Emerging roles of noncoding RNAs in multiple myeloma: A review

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