Derivation and Validation of a Risk Stratification System for Predicting Postoperative Cognitive Impairment

Liao, Yan; Su, Xunling; Ouyang, Wen; Lan, Li; Chen, Shuang; Chou, Jing; Yuan, Long

doi:10.1080/08941939.2020.1749327

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…However, due to the study setting in Europe, this prediction model may not be generalizable to Asians, especially to Chinese patients. Fortunately, in 2020, Liao et al [17] established another prediction model of postoperative cognitive impairment in patients aged 60 years or older called PreOp-BFS based on the literature studies and validated it in Chinese patients. To develop the risk scoring system, PreOp-BFS, Liao et al [17] extracted the risk factors and their odds ratio, relative risk, or hazard ratio values from the literature studies by considering the actual needs of clinical work.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study

Shen

Yao

2021

Gerontology

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Perioperative neurocognitive disorders (PNDs) refer to cognitive decline identified in the preoperative or postoperative period. It has been reported that the incidence of postoperative neurocognitive impairment after noncardiac surgery in patients older than 65 at 1 week was 25.8∼41.4%, and at 3 months 9.9∼12.7%. PNDs will last months or even develop to permanent dementia, leading to prolonged hospital stays, reduced quality of life, and increased mortality within 1 year. Despite the high incidence and poor prognosis of PNDs in the aged population, no effective clinical prediction model has been established to predict postoperative cognitive decline preoperatively. To develop a clinical prediction model for postoperative neurocognitive dysfunction, a prospective observational study (Clinical trial registration number: ChiCTR2000036304) will be performed in the Shanghai General Hospital during January 2021 to October 2022. A sample size of 675 patients aged >65 years old, male or female, and scheduled for elective major noncardiac surgery will be recruited. A battery of neuropsychological tests will be used to test the cognitive function of patients at 1 week, 1 month, and 3 months postoperatively. We will evaluate the associations of PNDs with a bunch of candidate predictors including general characteristics of patients, blood biomarkers, indices associated with anesthesia and surgery, retinal nerve-fiber layer thickness, and frailty index to develop the clinical prediction model by using multiple logistic regression analysis and least absolute shrinkage and the selection operator (LASSO) method. The <i>k</i>-fold cross-validation method will be utilized to validate the clinical prediction model. In conclusion, this study was aimed to develop a clinical prediction model for postoperative cognitive dysfunction of old patients. It is anticipated that the knowledge gained from this study will facilitate clinical decision-making for anesthetists and surgeons managing the aged patients undergoing noncardiac surgery.

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Section: Discussion/conclusionmentioning

confidence: 99%

Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study

Shen

Yao

2021

Gerontology

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“…The assessment has been tested and piloted in various surgical departments, such as orthopedics, gynecology and general surgery, and is also used there. The reliability of the procedure is in a very good range for a clinical test with an AUROC above 85% [6].…”

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confidence: 92%

“…In fact, a number of tests for each patient were available to verify individual risk factors [5]. With the help of the present assessment [6] for patients with non-cardiac surgical interventions, it is possible to prospectively determine the postoperative risk of cognitive impairment using five content-classified items. The approach of this assessment is practice-oriented and pragmatic.…”

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confidence: 99%

Prediction of Postoperative Cognitive Impairment. Ensuring Patient Safety with a Validated Structured Assessment

Petzold¹

2020

Journal of Investigative Surgery

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Derivation and Validation of a Risk Stratification System for Predicting Postoperative Cognitive Impairment

Cited by 2 publications

References 21 publications

Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study

Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study

Prediction of Postoperative Cognitive Impairment. Ensuring Patient Safety with a Validated Structured Assessment

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