2020
DOI: 10.37358/rc.20.5.8129
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Derivatives of 1,2,4-Triazole-3,4-Disubstituted Based on Aminoacids with Potential Biological Activity

Abstract: In order to obtain new substances with potential biological activity dipeptide derivatives from p-aminobenzoyl-phenylglycine and p-aminobenzoyl-phenylalanine were grafted on 1,2,4-triazolic heterocycle. The new synthesized compounds belong to the group of antimetabolites, group used in medicine for treating malignant tumors. Also, it is possible to study the correlation between chemical structure and biological activity of the new compounds.

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Cited by 1 publication
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“…Depending on the preparation conditions and the reactant nature, as well as due to the presence of thioamide group in triazole molecule, 5-mercapto-3,4 disubstituted-1,2,4-triazoles show the phenomenon of double reactivity, reacting as if they had a thionic structure (A) or a thiol structure (B). This behavior explains the presence of a reaction center at the sulfur atom from 5-position of five-membered heterocycle [48]. In order to obtain the information about the structure of 1,3,4-thiadiazoles (compounds VIII-XIII) and 1,2,4-triazoles (compounds XIV-XIX), the elemental analysis (Table 1) as well as the FT-IR (Figure 7) and 1 H-NMR spectra (Figure 8) were performed.…”
Section: Synthesis Of Thiadiazole and Triazole Derivativesmentioning
confidence: 84%
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“…Depending on the preparation conditions and the reactant nature, as well as due to the presence of thioamide group in triazole molecule, 5-mercapto-3,4 disubstituted-1,2,4-triazoles show the phenomenon of double reactivity, reacting as if they had a thionic structure (A) or a thiol structure (B). This behavior explains the presence of a reaction center at the sulfur atom from 5-position of five-membered heterocycle [48]. In order to obtain the information about the structure of 1,3,4-thiadiazoles (compounds VIII-XIII) and 1,2,4-triazoles (compounds XIV-XIX), the elemental analysis (Table 1) as well as the FT-IR (Figure 7) and 1 H-NMR spectra (Figure 8) were performed.…”
Section: Synthesis Of Thiadiazole and Triazole Derivativesmentioning
confidence: 84%
“…Depending on the preparation conditions and the reactant nature, as well as due to the presence of thioamide group in triazole molecule, 5-mercapto-3,4 disubstituted-1,2,4-triazoles show the phenomenon of double reactivity, reacting as if they had a thionic structure (A) or a thiol structure (B). This behavior explains the presence of a reaction center at the sulfur atom from 5-position of five-membered heterocycle [ 48 ].…”
Section: Resultsmentioning
confidence: 99%