Dried Blood Spots 2014
DOI: 10.1002/9781118890837.ch27
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Derivatization Techniques in Dried Blood Spot Analysis

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Cited by 3 publications
(5 citation statements)
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“…The sample preparation methods of DBS for neonatal screening include derivatization and non-derivatization techniques. [8][9][10] For low-sensitive mass spectrometers, derivatization method has been introduced to improve the signals detected by MS, which uses the principle that n-butanol can react with the carboxyl groups of amino acids or acylcarnitines to form butyl ester derivatives to increase the efficiency of ionization. 9 While for mass spectrometers with higher sensitivity, the non-derivatization methods have attracted increasing attention.…”
Section: Introductionmentioning
confidence: 99%
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“…The sample preparation methods of DBS for neonatal screening include derivatization and non-derivatization techniques. [8][9][10] For low-sensitive mass spectrometers, derivatization method has been introduced to improve the signals detected by MS, which uses the principle that n-butanol can react with the carboxyl groups of amino acids or acylcarnitines to form butyl ester derivatives to increase the efficiency of ionization. 9 While for mass spectrometers with higher sensitivity, the non-derivatization methods have attracted increasing attention.…”
Section: Introductionmentioning
confidence: 99%
“…Besides, considering the derivatization and non-derivatization methods rely on semi-quantitative assessments for the diagnosis of metabolic diseases, based on the ratio of the peak intensity of native metabolites and their isotope-labeled counterpart. [8][9][10] Herein, we developed a series of dried blood spot (DBS) reference materials containing 9 amino acids (AA) and 10 acylcarnitines (AC) for neonatal screening, representative of the most common inherited AA and AC metabolic disorders in newborn screening. Based on these reference materials, we distributed them to multi-centers and evaluated the standardization in 100 clinical samples with both derivatization and non-derivatization methods.…”
Section: Introductionmentioning
confidence: 99%
“…O significado de detectável deve ser especificado com um critério. É importante destacar que a detecção do método não é a sensibilidade do mesmo, pois este é um parâmetro relacionado à inclinação da curva analítica 24 Há vários interferentes que podem diminuir a estabilidade do sinal analítico em um instrumento, como a calibração 28 , interferência de matriz e baixas concentrações de analitos que possuem baixa eficiência de detecção na técnica de interesse [29][30][31][32][33][34][35] . A modificação de moléculas através de reações denominadas derivatizações são muito comuns em diversos contextos para o aumento da detectabilidade.…”
Section: Análise De Aminoácidos E Detectabilidade Do Sinal Analíticounclassified
“…A modificação de moléculas através de reações denominadas derivatizações são muito comuns em diversos contextos para o aumento da detectabilidade. Em toxicologia, por exemplo, onde as amostras são de matrizes complexas e as concentrações de analitos são baixas, os desafios da detectabilidade são interessantes e amplamente explorados na literatura [29][30][31][32][33][34][35] .…”
Section: Análise De Aminoácidos E Detectabilidade Do Sinal Analíticounclassified
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