Dermal collagen matrices for ventral hernia repair: comparative analysis in a rat model

Abstract

The three biologics exhibited different patterns and rates of cellular and vascular permeation in our rat model. AlloDerm implants exhibited the most rapid and extensive cellular infiltration, followed by Permacol. However, on gross examination, the AlloDerm implants thinned significantly by 6 months. In contrast, the Permacol and CollaMend implants appeared to be largely intact.

Giant Omphalocele: What's the Way to Go?

“…Despite most of the published series, as well as the highest cumulative number of patients treated with biologic mesh products for complex abdominal hernia repair, refers to AlloDerm, this review objectively supports the current trend that the use of these devices has moved away from allograft toward xenograft because of the larger and thicker available sizes and the favourable viscoelastic properties in these products [64] and the beneficial role of xenograft in reducing recurrence rates and surgical site complications in open abdominal hernia repair. These results are concordant with findings from high quality animal studies [53,61,62,65,66], but, given the lack randomized controlled trials studies, they need to be better confirmed. In the recent 10 years case reports of neonates with abdominal wall defects treated with AlloDerm [67][68][69] and a few case series of similar patients treated with Surgisis [56,[70][71][72] have been published.…”

“…Confirmation of those findings were reported in a rat incisional hernia model by Broderick et al [61], were AlloDerm implants exhibited the most rapid and extensive cellular infiltration, compared to Permacol, despite at 6 months both the meshes had evidence of cell penetration throughout the implants. However AlloDerm implants thinned significantly by 6 months, in contrast with Permacol [61]. The recent experience with Strattice showed similar properties to AlloDerm.…”

“…Timing for definitive repair should be guided by the patient's general conditions and by the naturally occurring relative reduction in size of the hernia compared to the growing abdominal cavity: whenever the abdominal capacity results big enough to attempt to allocate the herniated viscera, with or without complete escharification of the sac, the sac can be excised, hernia content reduced and abdomen closed by layered closure apposing the fascia with or without the use of a prosthetic patch. If a patch is required the suggested mesh to use is Permacol, the biologic mesh which confers the strongest and more durable repair with the lowest failure rate, performing well even in contaminated fields, while maintaining an adequate host tissue in-growth, collagen deposition, and neovascularisation [51,53,61,62,[64][65][66]. In case of big fascial defect, the wall components separation technique [15,47,48] can be used in order to reduce the size of the required prosthetic patch.…”

Porcine Dermal Collagen Prevents Seroma Formation After Mastectomy and Axillary Dissection in Rats

“…Its 3-dimensional structure increases fibroblast infiltration and neovascularization (5)(6)(7)(8). In repair of abdominal wall defects, it was seen that seroma formation was lower when porcine dermal collagen was used (6,9). According to these clinical observations, porcine dermal collagen was chosen in this experimental seroma model.…”

“…According to the studies in the literature, it was predicted that the 3-dimensional architecture of the porcine dermal collagen would increase fibroblast infiltration into the mesh and in this way there would be increase in fibrous tissue in pathological samples (6)(7)(8)(9). But no significance was found in the increase of fibrous tissue (p>0.05).…”