Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases

Huang, Jinwen; Heng, Shujun; Zhang, Wenlu; Liu, Youxi; Xia, Tian; Ji, Chao; Zhang, Lingjuan

doi:10.1016/j.semcdb.2022.02.027

Cited by 101 publications

(71 citation statements)

References 93 publications

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“…Wound healing can be considered as a sophisticated process, that involves several circumstances, such as coagulation, inflammation, cell division and migration, development of connective tissues and blood vessels (depending on the wound’s degree), growth of extracellular matrix (ECM), and epithelium maturity [ 21 ]. Moreover, ECMs regulates several biological functions, such as cell adhesion and their proliferation, cell differentiation, migration, their interactions, and intracellular signaling.…”

Section: Wound Dressingmentioning

confidence: 99%

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Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

et al. 2022

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Chronic ulcers are among the main causes of morbidity and mortality due to the high probability of infection and sepsis and therefore exert a significant impact on public health resources. Numerous types of dressings are used for the treatment of skin ulcers-each with different advantages and disadvantages. Bacterial cellulose (BC) has received enormous interest in the cosmetic, pharmaceutical, and medical fields due to its biological, physical, and mechanical characteristics, which enable the creation of polymer composites and blends with broad applications. In the medical field, BC was at first used in wound dressings, tissue regeneration, and artificial blood vessels. This material is suitable for treating various skin diseases due its considerable fluid retention and medication loading properties. BC membranes are used as a temporary dressing for skin treatments due to their excellent fit to the body, reduction in pain, and acceleration of epithelial regeneration. BC-based composites and blends have been evaluated and synthesized both in vitro and in vivo to create an ideal microenvironment for wound healing. This review describes different methods of producing and handling BC for use in the medical field and highlights the qualities of BC in detail with emphasis on biomedical reports that demonstrate its utility. Moreover, it gives an account of biomedical applications, especially for tissue engineering and wound dressing materials reported until date. This review also includes patents of BC applied as a wound dressing material.

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Section: Wound Dressingmentioning

confidence: 99%

“…The tissue remodeling phase involves the strengthening of the tissue through the synthesis of collagen and elastin. During this step, the wound keeps on contracting, and fibers are reorganized, forming a scar [ 21 ].…”

Section: Wound Dressingmentioning

confidence: 99%

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

et al. 2022

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“…To quantify the degree of crosslinking, the mechanical properties and water contact of non-crosslinking ADM sponge, VT-ADM, and GA-ADM were measured (Table 2) (Koosha et al, 2019). In addition, the existence and function of other components of the dermal matrix, such as elastin, hyaluronic acid, and matricellular proteins, in ADM sponges rather than collagen would be explored in further studies (Huang et al, 2022).…”

Section: Analysis Of Physicochemical Propertiesmentioning

confidence: 99%

A Comparative Study on Two Types of Porcine Acellular Dermal Matrix Sponges Prepared by Thermal Crosslinking and Thermal-Glutaraldehyde Crosslinking Matrix Microparticles

Huang

Ding

Pan³

et al. 2022

Front. Bioeng. Biotechnol.

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Common commercial porcine acellular dermal matrix (PADM) products take the form of a thin membrane. Given its dense structure, delaying vascularization after implantation remains an issue to be solved. In addition, overlaying multiple sheets to address deep wounds and large tissue defects that are difficult to repair by self-tissues could hinder tissue ingrowth, angiogenesis, and integration. Here, we creatively prepared PADM microparticles through a homogenizing treatment and crosslinked them to ADM sponges by thermal crosslinking (VT-ADM) and thermal-glutaraldehyde crosslinking (GA-ADM). The resulting VT-ADM was thicker than GA-ADM, and both maintained the natural dermal matrix microstructure and thermal stability. The porosity of GA-ADM (mean 82%) was lower than that of VT-ADM (mean 90.2%), but the mechanical strength and hydrophilicity were significantly higher. The two types of ADM sponges showed no obvious difference in cell adhesion and proliferation without cytotoxicity. Furthermore, the human adipose stem cells were co-cultured with ADM sponges which promoted proliferation, tube formation, and migration of endothelial cells, and the GA-ADM group exhibited better migration behavior. There were no markable differences among expressions of pro-angiogenesis genes, including vascular endothelial growth factor, insulin-like growth factor-1, and epidermal growth factor. In a nude mouse model, the VT-ADM and GA-ADM pre-cultured with human adipose stem cells for 1 week in advance were implanted subcutaneously. The VT-ADM and the GA-ADM showed great histocompatibility without local redness, swelling, or necrosis. The vascular density of the local skin flap above the material was visualized using indocyanine green and showed no statistical difference between the two groups. The collagen tissue deposition in the pores and vessel formation within the sponges increased with time. Although VT-ADM had a higher degradation rate in vivo, the integrity of the two scaffolds was preserved. Collectively, the VT-ADM and the GA-ADM retained a natural matrix structure and presented biocompatibility. Thus, the above-mentioned two crosslinking methods for ADM sponges are safe and practicable. The novel ADM sponges with good physicochemical and biological properties are no longer limited to membrane tissue regeneration but could also realize structure remodeling where they act as scaffolds for a soft tissue filler and three-dimensional reconstruction of the tissue with strength requirements.

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“…Small leucine-rich proteoglycans (SERPs) are a fast-increasing subfamily of extracellular PGs generated by vascular smooth muscle cells, with 13 members encoded by distinct genes (70,89) . SERPs modulate numerous biological processes, including cell proliferation and differentiation, inflammation and fibrosis, and modulation of secretion and action of several growth factors through bo-th structural and nonstructural functi-ons -within the vascular extracellular matrix, in addition to bone, cartilage, and myocytes matrix (69,90) . The core domain of osteoglycin (OGN), a class III SLRP, is characterized by leucinerich repeats with numerous glycosylation sites, and the human OGN gene is localized at 9q22.…”

Section: Diagnosis Of Diabetic Kidney Diseasementioning

confidence: 99%

Osteoinductive Factor and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Literature Review

Ramadan

2022

Sohag Medical Journal

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Diabetic kidney disease comprises a multifaceted etiopathology that includes glomerular hemodynamic changes, inflammation, oxidative stress, interstitial fibrosis, and tubular atrophy. Diabetic nephropathy (DN), or the pathological alterations in the capillaries caused by diabetes mellitus (DM), is the major cause of end-stage renal disease in diabetic individuals worldwide. Proteinuria, among other elements, as a diagnostic biomarker for DN, is a late change, and so does not detect controlled early nephropathic alterations. This needs the development of novel biomarkers that are more sensitive, specific, and early than proteinuria. Endothelial dysfunction and atherosclerosis are caused by DM, whereas glomerular hypertrophy, an increase in the extracellular matrix, and glomerular sclerosis are caused by DN. Osteoglycin/Osteoinductive Factor (OGN) is a secretory small leucine-rich matrix/basement proteoglycan that regulates lipid and glucose metabolic activity, collagen fibrillogenesis, and cytokine availability in a paracrine/endocrine manner, and has been linked to the development of atherosclerosis, neovascularization, and angiogenesis. OGN is a pathogenic effector and biomarker that is extremely relevant to DM and DN because of these properties. OGN appears to be a better biomarker for DN than microalbuminuria, according to research. This literature review is intended to offer the most recent findings relevant to OGN's DN biomarker potential.

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Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases

Cited by 101 publications

References 93 publications

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

A Comparative Study on Two Types of Porcine Acellular Dermal Matrix Sponges Prepared by Thermal Crosslinking and Thermal-Glutaraldehyde Crosslinking Matrix Microparticles

Osteoinductive Factor and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Literature Review

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