Dermal smartPearls – Optimized silica particles for commercial products &amp; mechanistic considerations

Hespeler, David; Pyo, Sung Min; Müller, Rainer H.

doi:10.1016/j.ijpharm.2019.118757

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Additionally, the pore size distribution centred at ca. 2.5 nm did not solely shift to lower values with the incorporation of CP, but also decreased greatly in volume ( Figure 2 b), indicating that CP is not adsorbed only as mono- or multilayers at this silica:drug ratio, but that it is indeed filling the pore [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…A weak endothermic peak was observed in the thermogram of MSN-CP-3-1, indicating the presence of traces of crystalline CP and its almost complete amorphisation. Thus, the amount of drug in the silica:drug ratio used in our study does not cause drug overloading, otherwise a thick CP layer would occur on the outer surface of the particle, leading to its crystallisation [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…The loading of a drug on MSNs strongly depends on the adsorptive properties of the MSN, as the drug–carrier interactions must be protagonists to minimise the fraction of the drug adsorbed on the outer particle surface so as to avoid its crystallisation due to the absence of (pore) confinement effects [ 9 , 10 ]. An amorphous state of the drug is desired, especially for poorly soluble drugs, as the conversion of the crystalline state to the amorphous form can improve the drug dissolution/release rate and bioavailability [ 11 , 12 ]. In this regard, the low aqueous solubility of some active pharmaceutical ingredients for skin treatments makes their formulation in aqueous delivery systems difficult, resulting in some penetration/permeation drawbacks, which consequently influence further clinical effects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process

et al. 2022

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The alliance between 3D printing and nanomaterials brings versatile properties to pharmaceuticals, but few studies have explored this approach in the development of skin delivery formulations. In this study, clobetasol propionate (CP) was loaded (about 25% w/w) in mesoporous silica nanomaterial (MSN) to formulate novel bioadhesive and hydrophilic skin delivery films composed of pectin (5% w/v) and carboxymethylcellulose (5% w/v) by 3D printing. As a hydrophobic model drug, CP was encapsulated in MSN at a 3:1 (w/w) ratio, resulting in a decrease of CP crystallinity and an increase of its dissolution efficiency after 72 h (65.70 ± 6.52%) as compared to CP dispersion (40.79 ± 4.75%), explained by its partial change to an amorphous form. The CP-loaded MSN was incorporated in an innovative hydrophilic 3D-printable ink composed of carboxymethylcellulose and pectin (1:1, w/w), which showed high tensile strength (3.613 ± 0.38 N, a homogenous drug dose (0.48 ± 0.032 mg/g per film) and complete CP release after 10 h. Moreover, the presence of pectin in the ink increased the skin adhesion of the films (work of adhesion of 782 ± 105 mN·mm). Therefore, the alliance between MSN and the novel printable ink composed of carboxymethylcellulose and pectin represents a new platform for the production of 3D-printed bioadhesive films, opening a new era in the development of skin delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process

et al. 2022

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“…This theoretical basis will contribute to future investigations on AHD storage and safe processing. 3…”

Section: H•••o and H•••clmentioning

confidence: 99%

“…1,2 The solid-state properties possess the potential to impact the penetrability, bioavailability, shelf life, and bioactivity of pharmaceutical products, thus significantly influencing their safety, efficacy, and quality. 3 Among various salt forms investigated, hydrochloride (HCl) salts have been extensively utilized in the pharmaceutical industry due to their low toxicity, high biocompatibility, and ability to preserve the inherent pharmacological properties of drugs. 4 The hydrous HCl salts, in which several water molecules are incorporated into their crystal lattices, represent the hydrated form of these counterparts.…”

Section: Introductionmentioning

confidence: 99%

Molecular Insights into Water–Chloride and Water–Water Interactions in the Supramolecular Architecture of Aconine Hydrochloride Dihydrate

Li,

Xu,

et al. 2024

ACS Omega

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Despite the previous preparation of aconine hydrochloride monohydrate (AHM), accurate determination of the crystal's composition was hindered by severely disordered water molecules within the crystal. In this study, we successfully prepared a new dihydrate form of the aconine hydrochloride [C 25 H 42 NO 9 + Cl − •2(H 2 O), aconine hydrochloride dihydrate (AHD)] and accurately refined all water molecules within the AHD crystal. Our objective is to elucidate both water−chloride and water−water interactions in the AHD crystal. The crystal structure of AHD was determined at 136 K using X-ray diffraction and a multipolar atom model was constructed by transferring chargedensity parameters to explore the topological features of key short contacts. By comparing the crystal structures of dihydrate and monohydrate forms, we have observed that both AHD and AHM exhibit identical aconine cations, except for variations in the number of water molecules present. In the AHD crystal, chloride anions and water molecules serve as pivotal connecting hubs to establish three-dimensional hydrogen bonding networks and one-dimensional hydrogen bonding chain; both water−chloride and water−water interactions assemble supramolecular architectures. The crystal packing of AHD exhibits a complete reversal in the stacking order compared to AHM, thereby emphasizing distinct disparities between them. Hirshfeld surface analysis reveals that H••• Cl − and H•••O contacts play a significant role in constructing the hydrogen bonding network and chain within these supramolecular architectures. Furthermore, topological analysis and electrostatic interaction energy confirm that both water−chloride and water− water interactions stabilize supramolecular architectures through electrostatic attraction facilitated by H•••Cl − and H•••O contacts. Importantly, these findings are strongly supported by the existing literature evidence. Consequently, navigating these water−chloride and water−water interactions is imperative for ensuring storage and safe processing of this pharmaceutical compound.

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Naproxen-loaded mesoporous silica nanoparticles: How can the process of incorporation affect drug placement, drug release and the in vitro naproxen irritant potential?

Funk,

Tavaniello,

Dos Santos

et al. 2025

Microporous and Mesoporous Materials

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Dermal smartPearls – Optimized silica particles for commercial products & mechanistic considerations

Cited by 4 publications

References 34 publications

Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process

Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process

Molecular Insights into Water–Chloride and Water–Water Interactions in the Supramolecular Architecture of Aconine Hydrochloride Dihydrate

Naproxen-loaded mesoporous silica nanoparticles: How can the process of incorporation affect drug placement, drug release and the in vitro naproxen irritant potential?

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