Dermasence refining gel modulates pathogenetic factors of rosacea in vitro

Borelli, Claudia; Becker, Beatrice; Thude, Sibylle; Fehrenbacher, Birgit; Isermann, Detlef

doi:10.1111/jocd.12323

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Although the term “neurogenic dysregulation” has been developed in relation to rosacea in the 20 th century, the pathogenesis mechanism has been difficult to elucidate, possibly due to limitations in technologies or the heterogeneity of the disease presentation. It has been found that some neurogenic events are regarded as vital components in patients with rosacea ( e.g ., sympathetic/axon reflex-mediated alterations [ 67 ], the neuropeptide calcitonin gene-related peptide (CGRP-α) [ 68 ], substance P [ 69 ], transient receptor potential vanilloid (TRPV) [ 70 ] and the vascular endothelial-derived growth factor (VEGF) family [ 71 ]). The detection of TRP channel activation is related to inflammatory skin conditions, itching, and pain [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Current research and clinical trends in rosacea pathogenesis

Hu¹,

Li²,

Zhang³

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

Current research and clinical trends in rosacea pathogenesis

Hu¹,

Li²,

Zhang³

et al. 2022

Heliyon

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“…Some components of cosmetic creams used in the treatment of rosacea inhibit KLK5, such as dextran sulfate, 4‐ t ‐butylcyclohexanol, pongamia oil, and hesperidin methyl chalcone [139]. Dermasence gel increases KLK5 and suppresses CAMP in a 3D human reconstructed epidermis [140]. Cream with the protease inhibitor ε‐aminocaproic acid (ACA) improves rosacea in patients (NCT01398280) [141].…”

Section: A Central Role Of Klks In Inflammationmentioning

confidence: 99%

Reconstructing the epidermal proteolytic cascades in health and disease

Sotiropoulou

Zingkou

Pampalakis

2022

The Journal of Pathology

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The epidermis is the outer stratified epithelium of the skin, forming the physical barrier that is indispensable for homeostasis. Epidermal proteolysis, mainly but not exclusively executed by kallikrein-related peptidases (KLKs), is tightly regulated to ensure maintenance of physiological skin renewal and an intact skin barrier. Perturbation of epidermal proteolytic networks is implicated in a wide array of rare and common skin pathologies of diverse genetic backgrounds. Recent studies of monogenic human skin diseases and newly developed animal models have revealed new mechanisms of regulation of proteolytic pathways in epidermal physiology and in disease states. These new data have challenged some accepted views, for example the role of matriptase in epidermal desquamation, which turned out to be restricted to mouse skin. The significance of PAR2 signaling in skin inflammation should also be reconsidered in the face of recent findings. Cumulatively, recent studies necessitate a sophisticated redefinition of the proteolytic and signaling pathways that operate in human skin. We elaborate how epidermal proteolysis is finely regulated at multiple levels, and in a spatial manner that has not been taken into consideration so far, in which specific proteases are confined to distinct epidermal sublayers. Of interest, transglutaminases have emerged as regulators of epidermal proteolysis and desquamation by spatially fixing endogenous protease inhibitors, constituting regulatory factors that were not recognized before. Furthermore, new evidence suggests a link between proteolysis and lipid metabolism. By synthesis of established notions and recent discoveries, we provide an up-to-date critical evaluation and synthesis of current knowledge and the extended complexity of proteolysis regulation and signaling pathways in skin.

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“…NHEKs at 70% confluence were exposed to different concentrations of recombinant human IL-33 (100 ng/ml; MACS, Auburn, CA, USA) and LL-37 peptides (0.5 μg/ml; ANYGEN, Jangseong, Korea). The expression of VEGF and TRPV1 was evaluated at times ranging from 0 to 48 h and doses ranging from 0.1 to 10 ng/ml 19 . Regulation of VEGF and TRPV1 was also evaluated after the cells were treated with citron essential oils at various concentrations (0.005%, 0.01%, and 0.02%).…”

Section: Expression and Regulation Of Vegf And Trpv1 Induced By Il-33mentioning

confidence: 99%

“…Interleukin 33 (IL-33), a pro-inflammatory cytokine and an inducer of Th2-mediated responses, has been reported to enhance VEGF expression in keratinocytes 18 . In addition, abnormally increased expression of LL-37 may induce VEGF expression in epidermal keratinocytes, which corresponds to the enhanced inflammation and vascular response seen in rosacea 19 .…”

Section: Introductionmentioning

confidence: 99%

Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes

Jeon

Yun

et al. 2018

Ann Dermatol

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Background: Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids. Objective: In this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes in vitro. Methods: Normal human epidermal keratinocytes (NHEKs) were stimulated with 1α, 25-dihydroxyvitamin D3 (VD3) and interleukin 33 (IL-33) with LL-37 to induce rosacea mediators such as kallikrein 5 (KLK5), cathelicidin, vascular endothelial growth factor (VEGF), and transient receptor potential vanilloid 1 (TRPV1). These mediators were analyzed by performing reverse-transcription polymerase chain reaction (PCR), quantitative real-time PCR, immunocytofluorescence and enzyme-linked immunosorbent assay after NHEKs were treated with citron seed and unripe citron essential oils. Results: The messenger RNA (mRNA) and protein levels of KLK5 and LL-37 induced by VD3 were suppressed by citron seed and unripe citron essential oils. Furthermore, the mRNA and protein levels of VEGF and TRPV1 induced by IL-33 with LL-37 were also suppressed by citron essential oils. Conclusion: These results show that citron essential oils have suppressive effects on rosacea mediators in activated epidermal keratinocytes, which indicates that the citron essential oils may be valuable adjuvant therapeutic agents for rosacea. (Ann Dermatol 30(6) 653∼661, 2018

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Dermasence refining gel modulates pathogenetic factors of rosacea in vitro

Abstract: We show evidence explaining the anti-inflammatory effect of Dermasence Refining Gel in rosacea pathogenesis in vitro. The adjunctive use of DRG in mild to moderate rosacea as a topical cosmetic seems medically reasonable.

Cited by 5 publications

References 18 publications

Current research and clinical trends in rosacea pathogenesis

Current research and clinical trends in rosacea pathogenesis

Reconstructing the epidermal proteolytic cascades in health and disease

Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes

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