Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

Bonciani, Diletta; Verdelli, Alice; Bonciolini, Veronica; D’Errico, Antonietta; Antiga, Emiliano; Fabbri, Paolo; Caproni, Marzia

doi:10.1155/2012/239691

Cited by 51 publications

(54 citation statements)

References 77 publications

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“…Furthermore, the PV/BP ratio in our study was 0.96, and this ratio was reported to be between 1.1-1.5 in previous reports from Turkey. Although the demographic and clinical characteristics of ABD patients were in accordance with previous studies, most of the DH patients in our study were female (3,6,7,10,13). It is known that DH affects males more frequently, but the predominance of female patients was also reported if there was an accompanying autoimmune disease, as in our study (10,13).…”

Section: Discussionsupporting

confidence: 87%

“…Although comorbid inflammatory and infectious conditions, malignancies, and endocrinological disorders have been mentioned in some patients in the literature, exogenous triggering factors may also play a role in the etiology of ABDs by regulating the immune response or by changing the antigenic properties of the epidermal basal membrane. Determining and removing these factors may aid in the prevention of exacerbations of the disease (8)(9)(10)(11)15). In this study, it was aimed to determine the triggering factors and comorbidities in newly diagnosed ABD patients in order to control the disease in a rapid way and to decrease morbidities.…”

Section: Discussionmentioning

confidence: 99%

“…Sex, age, age at onset of disease, the interval between the first complaint and the diagnosis, place of residence (rural or urban), family history, tobacco and alcohol habits (three groups: active smoker before the disease onset, former smoker but nonactive in the last 6 months, nonsmoker), triggering factors described by patients, and specific triggering factors of ABDs (e.g., medication, ultraviolet exposure, nutritional factors, chemical agent exposure, topical applications, infections, vaccination, emotional stress, trauma, malignancy, and/or radiotherapy history) were examined with a standardized questionnaire form. It was determined whether the drugs that were still in use had triggering properties (8)(9)(10)(11). Autoimmune Bullous Skin Disorder Intensity Scores (ABSISs) with localization and distribution of lesions were recorded following dermatological examinations (12).…”

Section: Methodsmentioning

confidence: 99%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…However, contrary to this traditional knowledge, incidence of infectious skin diseases was found higher in the eastern region which has relatively colder climate features than the coastal region which is hot and humid. This finding is associated with socioeconomic conditions and education levels of athletes in the eastern region (11,12).…”

Section: Resultsmentioning

confidence: 91%

Infectious dermatological diseases findings of the wrestlers according to regions

Kaynar¹

2018

J Turgut Ozal Med Cent

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Aim: Dermatologic diseases are commonly found in people engaged in contact sports. Particularly wrestlers can easily contract skin infections. The aim of this study is to reveal the incidence of infectious skin diseases engaged in wrestling athletes living in different climate regions. Material and Methods: Three hundred nineteen volunteer who actively wrestle in different climate regions of Turkey participated to the research. All of the athletes were asked the questions in the survey of "Personal History and Dermatological Examination Findings of Athlete". The findings and diagnoses of each wrestler were then recorded and evaluated. Results: Dermatological diseases were observed in 195 (61.12%) Turkish wrestlers, 84 (26.33%) in the eastern region, 43 (13.47%) in the inland region and 68 (21.32%) in the coastal region. These diseases were 118 (36.99%) fungal, 49 (15.36) bacterial and 28 (8.77%) viral, respectively. It was found that infectious dermatological diseases were observed more frequently in the eastern and coastal regions than inland region and this difference was statistically significant. (P = 0.045).

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“…In pathogenesis, HLA DQ2 and HLA DQ8 haplotypes are known to be involved, both in dermatitis herpetiformis and in celiac disease [7,8]. 90% of patients are DQ2 positive, and the remaining DQ8 [5,6].…”

Section: Discussionmentioning

confidence: 99%

Dermatitis herpetiformis: celiac disease of the skin. Report of two cases

Ortíz¹,

Macchi²,

Rebull³

et al. 2018

Our Dermatol Online

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SUMMARYDermatitis herpetiformis or Duhring-Brocq disease is a chronic, autoimmune, pleomorphic disease, characterized by lesions on extension surfaces, accompanied by intense pruritus, and is usually associated with celiac disease, gluten sensitivity, gluten sensitivity ataxia and some forms of IgA neuropathy. Two cases of dermatitis herpetiformis are presented in female patients and we make a brief review of the literature on the treatment of this pathology.

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Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

Cited by 51 publications

References 77 publications

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Infectious dermatological diseases findings of the wrestlers according to regions

Dermatitis herpetiformis: celiac disease of the skin. Report of two cases

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