Dermatofibroma‐like granular cell tumor

Cheng, Stephanie; Usmani, Arif S.; DeYoung, Barry R.; Ly, Micki N; Pellegrini, A.

doi:10.1034/j.1600-0560.2001.280106.x

Cited by 14 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Fanburg-Smith classification places this lesion into the atypical category. In addition, the histological features of the lesion examined closely resembled those of dermatofibroma-like granular cell tumour reported by Cheng et al (4). Dermatofibromas typically display hyperplasia of the overlying epidermis with elongation of the rete ridges and hyperpigmentation of the basal layer.…”

Section: Discussionsupporting

confidence: 51%

Dermatofibroma‐like Atypical Granular Cell Tumour

Hong¹,

Yang²,

Lee³

et al. 2005

Acta Dermato-Venereologica

View full text Add to dashboard Cite

Sir, Granular cell tumours (GCTs) are uncommon tumours that occur at a wide range of sites (1) and are characterized by granular, acidophilic cytoplasm that contains abundant lysosomes upon ultrastructural examination (2). Although they vary considerably in cellular and nuclear morphology, tumour cells tend to cluster into aggregates, with some situated between bands of collagen. The nuclei are small, round and centrally located, with no mitoses. GCTs are shown to express S-100 protein upon immunohistochemical examination and to contain numerous pleomorphic secondary lysosomes, including occasional angulate forms upon ultrastructural examination. We describe an atypical GCT with a histological architecture resembling that of a dermatofibroma. CASE REPORTA 48-year-old man presented with a solitary, round, dome-shaped hard nodule, 1.061.0 cm in size, and slightly yellow in colour in the pubic area which had grown over a period of 4 years (Fig. 1). The nodule was slow-growing, fixed and painful when subjected to pressure. Examination of haematoxylin and eosinstained sections revealed that the tumour was situated in the reticular dermis with extension into the papillary dermis and associated with mild hyperplasia of the overlying epidermis with elongation of the rete ridges and hyperpigmentation of the basal layer (Fig. 2 top). The tumour was made up of sheets of cells arranged singly and in nests or lobules separated by thin delicate collagen bundles. At the periphery of the lesion, tumour cells were arranged in a whorled pattern, and appeared to be infiltrating the surrounding tissue. The tumour cells were oval, polygonal to spindle-shaped with distinct cellular borders. The majority of cells had abundant eosinophilic granular cytoplasm and small, bland, eccentrically placed nuclei, and considerable variation in cellular and nuclear size was noted. The tumour cell nuclei showed prominent nucleoli, pleomorphism and nuclear contour irregularities (Fig. 2 bottom); however, no mitosis or necrosis was seen. Immunohistochemical staining revealed that tumour cells showed immunoreactivity for S-100, vimentin, neuron-specific enolase and CD68. No immunopositivity for desmin, smooth muscle actin, CD34, CD57, alpha-1-antitrypsin, MAC387, factor VIII and factor XIIIa was observed. Electron microscopy revealed that the tumour was composed of Fig. 2. (top) Hyperplasia of the overlying epidermis and hyperpigmentation of the basal layer (haematoxylin and eosin, original magnification 640). (bottom) Tumour cells show nuclear pleomorphism and prominent nucleoli (6200).Fig. 1. A dome-shaped, hard nodule in the pubic area. Acta Derm Venereol 85 Letters to the Editor

show abstract

Section: Discussionsupporting

confidence: 51%

Dermatofibroma‐like Atypical Granular Cell Tumour

Hong¹,

Yang²,

Lee³

et al. 2005

Acta Dermato-Venereologica

View full text Add to dashboard Cite

show abstract

“…Only two cases of granular cell tumour with prominent dermatofibroma-like morphology similar to our case have been described in the literature to date [12,13]. The first case [12] presented on the back of a 60-year-old Afro-American woman, while the second case [13] was localised in the pubic area of a 48-year-old man.…”

Section: Discussionmentioning

confidence: 96%

“…The diagnosis of an atypical granular cell tumour was made, based on Fanburg-Smith criteria [11]. To our knowledge, only two similar cases with prominent dermatofibroma-like morphology have been described in the literature so far [12,13]. …”

Section: Resultsmentioning

confidence: 99%

“…The first case [12] presented on the back of a 60-year-old Afro-American woman, while the second case [13] was localised in the pubic area of a 48-year-old man. All cases showed at least focal cell spindling and nuclei with prominent nucleoli, thus fulfilling criteria for an atypical GCT, although in none of the cases has recurrence been reported.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall

Soukup

Ryška

2016

pjp

View full text Add to dashboard Cite

Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Immunohistochemical analysis with antibodies against CD31, CD56, CD68, CD117, S-100 protein, inhibin, calretinin, EMA, p53 and MIB-1 was performed, showing expression of CD56, CD68, S-100 protein, inhibin and calretinin. The diagnosis of atypical dermatofibroma-like GCT was made.

show abstract

“…9 Cheng et al in 2001 described the histopathological findings in a case of dermatofibroma like granular cell tumor. 10 In such cases IHC is helpful as in contrast to classic Schwannian/neurogenic granular cell tumour, granular cell dermatofibroma is S100 negative and usually positive for NK1C3(CD57). In our case immunohistochemistry showed diffuse positivity for both S100 and CD57, thus favouring diagnosis of Granular cell tumor over granular cell dermatofibroma.…”

Section: Discussionmentioning

confidence: 99%

Infrascapular granular cell tumor: an unusual entity

Khan

Jetley

2017

Int J Adv Med

View full text Add to dashboard Cite

Granular cell tumor (GCT) is an uncommon soft tissue tumor of schwannian origin frequent among women and blacks between the second and sixth decades of life. The common location of GCT is the oral cavity, but it can also occur at other sites. Cutaneous lesions constitute about 30% of cases and are characterized by a gradually developing nodular lesion. Due to their subtle clinical appearance and symptomatology, GCTs are often misdiagnosed. We report a case of subcutaneous GCT in the infrascapular region in a 40 year old female which mimicked granular cell dermatofibroma on histopathology. Although a rare entity, Granular cell tumor should be considered in the differential diagnosis of the subcutaneous soft tissue tumours and require histopathological examination along with immunohistochemistry to confirm the diagnosis and differentiate them from other benign and malignant tumors showing granular cell change.

show abstract

Dermatofibroma‐like granular cell tumor

Abstract: The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma-like pattern.

Cited by 14 publications

References 22 publications

Dermatofibroma‐like Atypical Granular Cell Tumour

Dermatofibroma‐like Atypical Granular Cell Tumour

Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall

Infrascapular granular cell tumor: an unusual entity

Contact Info

Product

Resources

About