Dermatologists may need to pay more attention to herpes zoster during the pandemic of COVID-19

Wang, Bin; Guo, Shujing; Yao, Yue; Li, Yanjia; Zhang, Guoqiang

doi:10.1080/23744235.2020.1797158

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…Previous case reports, case series, and descriptive analyses have suggested a possible association between COVID-19 and HZ [ 7–9 , 20–23 ]. However, as these types of studies provide low-grade evidence for an association, it has not previously been possible to determine whether patients with COVID-19 have a higher risk of developing HZ.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States

Bhavsar

Lonnet²,

Wang

et al. 2022

Open Forum Infectious Diseases

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Background Case reports have described herpes zoster (HZ) in patients with COVID-19. However, this constitutes low-quality evidence for an association. We therefore performed a retrospective cohort study to assess the risk of developing HZ following a COVID-19 diagnosis. Methods We compared the HZ incidence in ≥50-year-olds diagnosed with COVID-19 versus those never diagnosed with COVID-19. We used data from the US MarketScan Commercial Claims and Encounters and Medicare Supplemental (3/2020-2/2021) and Optum Clinformatics Data Mart (3-12/2020) databases. Individuals with COVID-19 were exact-matched 1:4 to those without COVID-19 by age, sex, presence of HZ risk factors and health-care cost level. Adjusted incidence rate ratios (aIRRs) were estimated by Poisson regression. Results 394,677 individuals ≥50 years old with COVID-19 were matched with 1,577,346 individuals without COVID-19. Mean follow-up time after COVID-19 diagnosis and baseline characteristics were balanced between cohorts. Individuals diagnosed with COVID-19 had a 15% higher HZ risk than those without COVID-19 (aIRR: 1.15, 95% confidence interval [CI]: 1.07-1.24; p<0.001). The increased HZ risk was more pronounced (21%) following COVID-19 hospitalization (aIRR: 1.21, 95%CI: 1.03-1.41; p=0.02). Conclusions We found that COVID-19 diagnosis in ≥50-year-olds was associated with a significantly increased risk of developing HZ, highlighting the relevance of maintaining HZ vaccination.

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Section: Discussionmentioning

confidence: 99%

Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States

Bhavsar

Lonnet²,

Wang

et al. 2022

Open Forum Infectious Diseases

View full text Add to dashboard Cite

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“…Arora et al, 2021 , Furer et al, 2021 , Gershon et al, 2015 , Kamphuis et al, 2006 , Ku et al, 2016 , Márcia et al, 2020 , Marra et al, 2020 , Marzano et al, 2020 , Mulligan et al, 2020 , Nofal et al, 2020 , van Oorschot et al, 2021 , Bhardwaj et al, 2021 , Pona et al, 2020 , Qin et al, 2020 , Rodríguez-Jiménez et al, 2021 , Saati et al, 2020 , Sahin et al, 2020 , Tartari et al, 2020 , Tessas and Kluger, 2021 , Wang et al, 2020 , Wang et al, 2020 , Bostan and Yalici-Armagan, 2021 , Wei et al, 2017 , Wang et al, 2020 , Brambilla et al, 2020 , Dayan and Peleg, 2017 , Eid et al, 2021 , Elsaie et al, 2020 , Ferreira et al, 2020 , Folegatti et al, 2020 …”

Section: Uncited Referencesmentioning

confidence: 99%

Herpes zoster after COVID vaccination

Dam

Lede²,

Schaar

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Reactivation of oral herpes virus (HSV-1) lesions have also been observed [3,5]. There have been recent clinical reports of herpes zoster in patients affected by COVID-19 [6][7][8]. Herpes zoster is caused by the varicellazoster virus (VZV), a DNA virus of the Herpesviridae (HHV-3) family.…”

Section: Discussionmentioning

confidence: 99%

“…Herpes zoster is caused by the varicellazoster virus (VZV), a DNA virus of the Herpesviridae (HHV-3) family. The clinical presentation can be recurrent and presents in dermatomes that are likely dormant at their corresponding dorsal root ganglia [6][7][8]. Herpes zoster can occur in immunocompromised patients and patients experiencing stress or increased sunlight exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Herpes zoster can occur in immunocompromised patients and patients experiencing stress or increased sunlight exposure. A common associated symptom is postherpetic neuralgia, which is characterized as sensitive, burning, and painful skin in the same area where the rash once was but has clinically resolved with the neuralgia persisting [6][7][8][9]. SARS-CoV-2 affects many systems including the pulmonary, circulatory, hematologic, immunologic, and other systems/organs that differ from many of the common responses seen when similar viruses infect humans [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

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Recurrent herpes zoster with IgD deposits, multinucleated keratinocytes and overexpression of galectin and glypican 3 in a patient with SARS-COVID-19 infection

Velez¹,

Thomason²,

Jackson³

et al. 2022

Our Dermatol Online

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The novel coronavirus disease (COVID-19) that currently plagues the world and caused by SARS-CoV-2, has spread internationally since late 2019. The dermatologic manifestations of this virus are currently being identified. We describe a 73-year-old Caucasian female who presented to many physicians for recurrent Herpes zoster episodes that persisted, despite treatment with multiple antiviral medications. The patient was diagnosed with COVID-19 before an onset of vesicular pustular lesions. The clinical diagnoses were recurrent herpes zoster and recurrent varicella. A skin biopsy was obtained and stained with hematoxylin and eosin to confirm a diagnosis. Immunohistochemical stains for Ki-67, Phospho-Histone H3, galectin 3, glypican and IgD were positive in multinucleated cells of the skin, where the viral lesions were detected. Recidivated herpes zoster and varicella are currently being clinically associated with COVID- 19; the abnormal immune response in patients with COVID-19 may be due to the overexpression of molecules that facilitate the outbreak of these viruses.

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Dermatologists may need to pay more attention to herpes zoster during the pandemic of COVID-19

Cited by 8 publications

References 10 publications

Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States

Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States

Herpes zoster after COVID vaccination

Recurrent herpes zoster with IgD deposits, multinucleated keratinocytes and overexpression of galectin and glypican 3 in a patient with SARS-COVID-19 infection

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