Dermatophytosis

Weitzman, Irene

doi:10.1007/978-1-4612-3898-0_64

Cited by 1 publication

(2 citation statements)

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“…1 The host immune response against infections caused by dermatophytes depends on factors such as the host defenses against metabolites of the fungus, the virulence of the infecting strain or species, the anatomical site of infection and local environmental factors. 1 The most prevalent dermatophytes are mainly those of the genera -Trichophyton, Microsporum and Epidermophyton, 2 classified as anthropophilic, zoophilic and geophilic according to their primary habitat. 3,4 The most common infection in the Americas and in parts of Europe is caused by anthropophilic dermatophytes.…”

Section: Introductionmentioning

confidence: 99%

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Micoses superficiais e os elementos da resposta imune

Criado

Oliveira

Dantas

et al. 2011

An. Bras. Dermatol.

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Superficial mycoses are prevalent worldwide. They are often caused by dermatophytes and restricted to the stratum corneum. The host's immune response against infections caused by dermatophytes basically depends on the host's defense against metabolites of the fungi, virulence of the infecting strain or species and anatomical site of the infection. We will review some of the factors of the host's immune defense that influence the efficacy of the immune response. We will particularly review the role of pattern recognition receptors (PRRs), such as toll-like receptors or lectin receptors (DCSIGN and Dectin 2), which participate in the innate immune response, bringing specificity to the immune response and setting its pattern. The predominance of a cellular or humoral immune response determines the clinical manifestations and the prognosis of the infection, leading to healing or chronicity. Keywords: Allergy and immunology; Fungi; Inflammation mediators; Integumentary system Resumo: As micoses superficiais são prevalentes em todo o mundo, geralmente ocasionadas por dermatófitos e restritas à camada córnea. A resposta imunológica do hospedeiro às infecções dos fungos dermatófitos depende basicamente das defesas do hospedeiro a metabólitos do fungo, da virulência da cepa ou da espécie infectante e da localização anatômica da infecção. Serão revistos alguns dos fatores da defesa imunológica do hospedeiro que influenciam na eficácia da resposta imune. Em especial, a participação dos receptores de padrão de reconhecimento (PRRs), tais como os receptores toll-like ou os da família lectina (DC-SIGN e dectin-2), que participam da resposta imune inata, conferindo-lhe especificidade e definindo o padrão da resposta imune como um todo. O predomínio celular ou humoral da resposta imune definirá o quadro clínico e o prognóstico da infecção, levando à cura ou cronicidade.

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Section: Introductionmentioning

confidence: 99%

“…4 Transfer of infectious soil organisms to other animals or humans occurs through arthrospores, skin scales or hair, with direct contact not being necessary. 1 Invasion of the skin follows adhesion of fungal cells to keratinocytes. 6 …”

Section: Introductionmentioning

confidence: 99%