Dermatophytosis

CaCO3-based carriers with prolonged release properties for antifungal drug delivery to hair follicles

“…112 In addition, since dermatophytes invade hair follicles, which often causes re-infection, the intrafollicular delivery of Gf becomes beneficial in the treatment of fungal skin infections. 41–45…”

“…112 In addition, since dermatophytes invade hair follicles, which often causes re-infection, the intrafollicular delivery of Gf becomes beneficial in the treatment of fungal skin infections. [41][42][43][44][45] In our previous studies, vaterite matrices were successfully exploited for drug transportation into the skin. 46,[49][50][51]138 We have conclusively demonstrated in mice, rats, and human volunteers that the topical application of such carriers, followed by the therapeutic ultrasound treatment (sonophoresis), resulted in their deep penetration through the skin along with the plentiful filling of the hair follicles.…”

“…[41][42][43][44] Thus, in this case, until the infection is eradicated within the hair follicle, reseeding with these spores might continuously occur. 45 By this means, topical antifungal formulations could get extra benefit from the use of various micro-and nanoparticles as drug carriers if such a particulate system could facilitate delivery to hair follicles.…”

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

“…There was no statistical difference between cat and dog species for each treatment group. Ketaconazole treatment was expected to work well in light of previous scientific study reports (Endo et al, 2020;Moriello, 2020;Brescini et al, 2021;Anikar et al, 2022). However, the treatment rates observed in the HP group were not far below the KT group data.…”

“…In natural conditions, aromatic amino acids, collagen, elastin, melanin precursors and products in the skin content fluoresce in this way (Sav, 2017;Moriello, 2019;Türkmen and Türkoğlu, 2019). It is reported that Wood's light is used in the diagnosis of dermatophytosis with an accuracy rate of 91% (Moriello, 2020). In another paper, it is reported that in cases of dermatophytosis, false negative results can be obtained in 20% of cats and 5.8% in dogs for Wood's lamp examination results (Moriello, 2004).…”